Tencef

Tencef Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Tencef is a brand name. Its generic name is Ceftibuten.

Introduction

Tencef (brand name CEDAX) is a third-generation cephalosporin antibiotic, an antibiotic used to treat a variety of bacterial infections. Tencef is usually prescribed to treat bacterial infections such as bronchitis, sinusitis, urinary tract infections, and skin infections including abscesses, boils, and infected wounds.

Uses for

Tencef is used to treat a variety of bacterial infections including bronchitis, sinusitis, urinary tract infections, and skin infections including abscesses, boils, and infected wounds. Tencef is also used to prevent certain infections in people with weakened immune systems.

Mechanism Of Action

Tencef works by targeting and destroying bacteria and stopping them from reproducing and spreading. The antibiotic works by inhibiting bacterial cell wall synthesis, preventing bacteria from forming the protective outer layer that is essential for their survival. Tencef also interferes with bacterial DNA replication, preventing bacteria from reproducing.

How Long Does It Take to Work?

Tencef typically takes 24-48 hours before it begins to take effect, depending on the severity of the infection. Most people see improvement in their symptoms within a few days once the antibiotic has taken effect.

Absorption

Tencef is rapidly and completely absorbed after oral administration, reaching maximum plasma levels within 1-2 hours. The drug has an absolute bioavailability of 100%, meaning that all of the drug is absorbed and utilized by the body.

Route of Elimination

Tencef is eliminated primarily by the kidneys, with up to 80% of the drug being excreted unchanged in the urine within 24 hours after administration.

Dosage

The dosage of Tencef will vary based on the type and severity of the infection being treated. Typical doses for adults range from 400 mg once a day to 600 mg every 12 hours. The total daily dose should not exceed 1.2 grams.

Administration

Tencef is administered orally and is available as a tablet, liquid, and granules for suspension. It should be taken with food or a full glass of water to reduce the risk of stomach upset.

Side Effects

Common side effects of Tencef include nausea, vomiting, diarrhoea, abdominal pain, and headache. It can also cause hypersensitivity reactions such as rash and itching.

Toxicity

Tencef is generally well tolerated, though high doses can cause kidney damage. Overdoses of Tencef can cause significant falls in blood pressure and can be fatal.

Precaution

Tencef should not be used by people who are allergic to any of the ingredients in the drug. It should also not be used by pregnant women or women who are breastfeeding.

Interaction

Tencef may interact with other drugs, including diuretics, NSAIDs, oral contraceptives, and blood thinners. It may also interact with certain foods, such as milk, cheese, and yogurt.

Disease Interaction

Tencef should not be used in people who have an infection caused by penicillin-resistant bacteria. It may also reduce the effectiveness of certain vaccines.

Drug Interaction

Tencef may interact with other drugs, including diuretics, NSAIDs, oral contraceptives, and blood thinners.

Food Interactions

Tencef may interact with certain foods, such as milk, cheese, and yogurt. It is important to avoid these foods while taking Tencef.

Pregnancy Use

Tencef is not recommended for use by pregnant women.

Lactation Use

Tencef should not be used by women who are breastfeeding.

Acute Overdose

An overdose of Tencef can cause significant drops in blood pressure and can be fatal. In such cases, the patient should seek immediate medical attention.

Contraindication

Tencef should not be used by people who are allergic to any of the ingredients in the drug.

Use Direction

Tencef should be taken at the same time each day, with or without food. It is important to take the full amount of medication prescribed by the doctor, even if symptoms improve.

Storage Condition

Tencef should be stored at room temperature, away from direct sunlight and moisture. It should be kept in a tightly sealed container.

Volume Of Distribution

Tencef has an apparent volume of distribution of 0.22-0.37 L/kg.

Half-Life

The half-life of ceftibuten is 2.7-3.9 hours.

Clearance

Tencef has a clearance of 0.2-0.3 L/hr/kg.

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