Stoma
Stoma Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Stoma is a brand name. Its generic name is Aluminium Hydroxide.
Stoma
Aluminium hydroxide is a type of antacid medication used to relieve symptoms associated with gastrointestinal distress like heartburn, indigestion, and stomach ulcers. It is typically taken orally, either through an oral suspension or tablet.
Uses
Aluminium hydroxide is used to treat a variety of gastrointestinal disorders such as acid reflux, GERD, and peptic ulcers by neutralizing the hydrochloric acid present in the stomach. It also works to reduce the symptoms of other digestive disorders such as heartburn, indigestion, and ulcerative colitis.
Mechanism of Action
Aluminium hydroxide works by neutralizing the stomach acid and forming a protective cover on the walls of the stomach, effectively reducing the production of hydrochloric acid in the stomach and relieving the symptoms associated with gastrointestinal distress. This mechanism of action makes it a very effective and widely used antacid.
How Long Does It Take to Work?
Aluminium hydroxide generally takes 30 minutes to 1 hour to start working it's effect after it has been ingested. The effects generally last for up to 4 to 6 hours and can be taken several times a day with doctor's recommendation.
Absorption
Aluminium hydroxide is not readily absorbed in the body, instead it forms a protective barrier on stomach walls and reduces the acidity of the stomach hydrochloric acid. It works best when taken on an empty stomach.
Route of Elimination
Aluminium hydroxide is eliminated through the digestive tract. The reaction of the medication reduces acidity and protects the stomach, which helps the body remove the ingested food. It can take several hours or days for the medication to be excreted from the body.
Dosage
Dosage of aluminium hydroxide depends on the body's response to the medication. The usual dosage is between 2-4 grams, taken 2-4 times daily. Dosage can be modified depending on the condition being treated and the severity of the gastric distress. It is generally taken with food and water, but can also be taken on an empty stomach.
Administration
Aluminium hydroxide is typically administered orally either in a suspension or as a tablet. Dosage and instructions should be followed strictly as directed by a doctor or pharmacist.
Side Effects
The most common side effects of aluminium hydroxide are gastrointestinal in nature, such as nausea, vomiting, constipation, and abdominal pain. Other side effects include dizziness, headache, and metallic taste. More serious side effects are less common but could include renal failure, seizures, or anaphylaxis.
Toxicity
Aluminium hydroxide is generally considered safe and non-toxic. As with any medication, it is important to follow the directions and dosage closely. Overdoses can lead to serious health issues, such as kidney failure or seizures.
Precaution
Aluminium hydroxide is typically well tolerated and considered safe, but as with any medication, there are certain precautions to take when taking it. People allergic or sensitive to aluminium should not use aluminium hydroxide. It should also be used with caution in those with impaired renal function, as aluminium hydroxide can accumulate in the body and lead to toxicity.
Interaction
Aluminium hydroxide may interact with a variety of drugs, including antibiotics and antacids, potentially increasing side effects or decreasing efficacy. It is important to consult with a healthcare professional before taking this medication to determine if any potential drug interactions may occur.
Disease Interaction
Aluminium hydroxide may interact with underlying conditions and diseases, such as kidney disease or osteoporosis, and may potentially worsen conditions or interfere with other medications being taken to manage the condition. It is important to inform healthcare providers of any underlying condition before taking this medication.
Drug Interaction
Aluminium hydroxide may interact with other medications, including antibiotics and antacids, potentially increasing side effects or decreasing efficacy. It is important to inform healthcare providers of all medications taken prior to taking this medication.
Food Interactions
Aluminium hydroxide may interact with certain foods, such as dairy products or calcium supplements, potentially reducing the efficacy of the medication or increasing gastrointestinal side effects. It is important to inform healthcare providers of any dietary restrictions or current dietary regimens.
Pregnancy Use
The use of aluminium hydroxide during pregnancy is generally avoided. There is not enough research to guarantee safety to pregnant women. It is important to consult with a healthcare professional before taking this medication while pregnant.
Lactation Use
There is limited data on the use of aluminium hydroxide during lactation. It is advised to consult with a healthcare provider prior to taking this medication while breastfeeding.
Acute Overdose
An acute overdose of aluminium hydroxide can be potentially serious and should be taken seriously. Side effects of overdose can be severe and include vomiting, abdominal pain, vertigo, weakness, and confusion. It is important to seek medical attention if an overdose is suspected.
Contraindication
Aluminium hydroxide is contraindicated in people who are allergic or sensitive to aluminium, and those with renal impairment. Any underlying conditions should be discussed with a healthcare professional prior to taking this medication.
Use Direction
Aluminium hydroxide should be taken according to doctor's instructions or written instructions provided on the packaging. It is typically taken orally either in a suspension or tablet form. It is generally advised to take aluminium hydroxide with food or an antacid to minimize side effects and ensure the medication is working effectively.
Storage Condition
Aluminium hydroxide should be stored away from direct sunlight, heat, or moisture. Any unused medication should be disposed of according to local regulations.
Volume of Distribution
The volume of distribution is the amount of a drug that distributes throughout the body and reaches the target tissue. Aluminium hydroxide has a volume of distribution of 0.24-0.45 L/Kg.
Half-Life
The half-life of a drug is the time required for the concentration of the drug to drop to one-half of its initial value. The half-life of aluminium hydroxide is approximately 16 hours.
Clearance
The clearance of a drug is a measure of the amount of drug that is removed from the blood. Aluminium hydroxide has a clearance of approximately 0.34 L/hr/kg.
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