Sorbid

Sorbid Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Sorbid is a brand name. Its generic name is Isosorbide Dinitrate.

Introduction

Isosorbide dinitrate (ISDN) is an organic nitrate medication used to treat angina, congestive heart failure, and pulmonary hypertension. It is a derivative of the organic nitrate nitroglycerin, and is available in the form of tablets, capsules, or sublingual pills.

Uses

Isosorbide dinitrate is primarily used to treat angina or chest pain by decreasing the workload of the heart and decreasing oxygen demand. It is also used to treat congestive heart failure and pulmonary hypertension.

Mechanism of Action

Isosorbide dinitrate works by decreasing the workload of the heart by relaxing and widening the blood vessels, thereby decreasing the pressure on the heart and decreasing oxygen demand. This reduces the chest pain or angina symptoms.

How Long Does It Take to Work?

The effects of isosorbide dinitrate may take up to 30 minutes to be felt, although they may be more rapid in some people.

Absorption

Isosorbide dinitrate is rapidly absorbed into the bloodstream after ingestion, with peak plasma concentrations reached within 1-2 hours.

Route of Elimination

Isosorbide dinitrate is metabolized primarily by the liver, and most of the metabolites are eliminated in the urine.

Dosage

Isosorbide dinitrate is available in 5mg, 10mg, 20mg, and 40mg tablets. The initial dose is usually 5 or 10mg taken every 4-6 hours, with the daily dose not usually exceeding 120mg. The dose of the medication should be gradually decreased when it is stopped.

Administration

Isosorbide dinitrate should be taken orally with or without food. It is also available as a sublingual tablet which should be placed under the tongue and allowed to dissolve.

Side Effects

Common side effects of isosorbide dinitrate include headache, dizziness, nausea, lightheadedness, fatigue, and hypotension (low blood pressure).

Toxicity

The toxicity of isosorbide dinitrate is generally low. High doses can cause excessive hypotension, which may lead to fainting or loss of consciousness.

Precautions

People with certain health conditions should use isosorbide dinitrate with caution, including those with anemia, kidney or liver disease, thyroid disease, heart disease, low blood pressure, or a history of alcohol abuse or drug addiction.

Interaction

Isosorbide dinitrate may interact with other medications, such as antihypertensives, beta-blockers, antiarrhythmics, calcium channel blockers, antidepressants, and certain antibiotics.

Disease Interaction

Isosorbide dinitrate may interact with certain diseases, such as anemia, kidney or liver disease, thyroid disease, heart disease, low blood pressure, or a history of alcohol abuse or drug addiction.

Drug Interaction

Isosorbide dinitrate may interact with other medications, such as antihypertensives, beta-blockers, antiarrhythmics, calcium channel blockers, antidepressants, and certain antibiotics.

Food Interactions

Isosorbide dinitrate should not be taken with grapefruit juice or other citrus juices as this could increase the risk of side effects.

Pregnancy Use

Isosorbide dinitrate should not be used in pregnant women as it can cross the placenta and can cause harm to a developing baby.

Lactation Use

Isosorbide dinitrate should not be used by breastfeeding women as it is excreted in breast milk and could affect a nursing infant.

Acute Overdose

Signs of an acute overdose of isosorbide dinitrate include a rapid decrease in blood pressure, dizziness, and fainting.

Contraindication

Isosorbide dinitrate is contraindicated in people with severe anemia, heart failure, or recent heart attack.

Use Direction

The usual adult dose of isosorbide dinitrate is 5-40mg taken orally every 4-6 hours. The maximum daily dose is 120mg.

Storage Condition

Isosorbide dinitrate should be stored at room temperature, away from heat, light, and humidity.

Volume of Distribution

The volume of distribution of isosorbide dinitrate is approximately 10L/kg.

Half Life

The half life of isosorbide dinitrate is approximately 2.5 hours.

Clearance

The clearance of isosorbide dinitrate is approximately 12 mL/min/kg.

Here you find in details version of Sorbid

Some Frequently Asked Questions About Sorbid

What is Isosorbide dinitrate?

Isosorbide dinitrate is a type of medicine called nitrate that is used to treat chest pain (angina) caused by coronary artery disease. It helps to reduce the number of angina attacks by widening the blood vessels in the heart and elsewhere in the body.

How does Isosorbide dinitrate work?

Isosorbide dinitrate works by relaxing and widening the blood vessels in the heart and elsewhere in the body. This helps to reduce the amount of work the heart has to do and increases the supply of blood and oxygen to the heart.

What are the conditions that Isosorbide dinitrate must be taken for?

Isosorbide dinitrate is used chiefly for the prevention and treatment of angina. It is also used to treat certain heart conditions, such as hypertension, aortic stenosis, and congestive heart failure.

What forms does Isosorbide dinitrate come in?

Isosorbide dinitrate is available in the form of an oral tablet, an oral solution, a transdermal patch, an intravenous solution, and a rectal suppository.

How should Isosorbide dinitrate be taken?

Isosorbide dinitrate should be taken exactly as directed by your doctor. Do not take more or less of it than directed. If you miss a dose, take it as soon as you remember. Do not take it more than four times in one day.

Are there any risks associated with taking Isosorbide dinitrate?

There are several risks associated with taking Isosorbide dinitrate, including low blood pressure, irregular heartbeat, and allergic reactions. If you experience any of these side effects, consult your doctor immediately.

What should be avoided while taking Isosorbide dinitrate?

Alcohol, certain medications, and certain substances may interact with Isosorbide dinitrate and increase the risk of side effects. Therefore, it is important to inform your doctor or pharmacist of all the medications and supplements that you are taking prior to using Isosorbide dinitrate.

Is there anything else to be aware of when taking Isosorbide dinitrate?

Consult your doctor or pharmacist about any other precautions or warnings related to Isosorbide dinitrate. It is important to let your doctor or pharmacist know if you are pregnant or breastfeeding before taking Isosorbide dinitrate.

What are the common side effects of Isosorbide dinitrate?

The most common side effects of Isosorbide dinitrate include headache, dizziness, nausea, and low blood pressure. If you experience any of these side effects, consult your doctor immediately.

What should be done in case of an overdose of Isosorbide dinitrate?

If you suspect an overdose of Isosorbide dinitrate, contact your local poison control center or emergency room immediately. Symptoms of an overdose may include headache, nausea, dizziness, low blood pressure, irregular heartbeat, and fainting.

How long does it take for Isosorbide dinitrate to work?

It usually takes 15-30 minutes for Isosorbide dinitrate to take effect, but this can vary depending on the person and the specific form of Isosorbide dinitrate being used.

What should I do if I experience an allergic reaction to Isosorbide dinitrate?

If you experience a rash, itching, or difficulty breathing after taking Isosorbide dinitrate, seek medical attention immediately. You may be experiencing an allergic reaction and should discontinue use of the drug.

Can Isosorbide dinitrate be taken with other medications?

Certain medications may interact with Isosorbide dinitrate and increase the risk of side effects. If you are taking any other medications, including over-the-counter medications, check with your doctor or pharmacist before taking Isosorbide dinitrate.

Can Isosorbide dinitrate cause weight gain?

Weight gain is not a common side effect of Isosorbide dinitrate. If you experience sudden weight gain while taking Isosorbide dinitrate, contact your doctor.

Can Isosorbide dinitrate be taken with alcohol?

It is not recommended to combine Isosorbide dinitrate with alcohol. Alcohol can increase the risk of side effects such as dizziness, lightheadedness, low blood pressure, and irregular heartbeat. If you must consume alcohol, talk to your doctor about how much is safe to consume.

Can Isosorbide dinitrate be taken while pregnant?

Isosorbide dinitrate is classified as a Pregnancy Category C drug which means that it may be harmful to the developing fetus. Therefore, it is important to consult your doctor or pharmacist before using Isosorbide dinitrate if you are pregnant or planning to become pregnant.

Can Isosorbide dinitrate be taken while breastfeeding?

It is not known if Isosorbide dinitrate passes into breast milk. Therefore, it is important to consult your doctor or pharmacist before using Isosorbide dinitrate if you are breastfeeding.

What are the long-term effects of Isosorbide dinitrate?

Long-term use of Isosorbide dinitrate can increase the risk of developing a tolerance to the drug or rebound angina. Talk to your doctor about the potential long-term effects of taking Isosorbide dinitrate.

Does Isosorbide dinitrate interact with any foods?

To date, there are no reports of any food-drug interactions associated with Isosorbide dinitrate. However, it is always a good idea to consult your doctor or pharmacist before taking any medication while consuming certain foods.

What is the recommended dosage of Isosorbide dinitrate?

The recommended dose of Isosorbide dinitrate is dependent on the individual and the type of medication being taken. It is important to follow the directions given by your doctor and/or pharmacist when taking Isosorbide dinitrate.

What should I do if I miss a dose of Isosorbide dinitrate?

If you forget to take a dose of Isosorbide dinitrate, take it as soon as you remember. Do not take more than 4 doses in one day. If it is close to the time of your next dose, skip the missed dose and continue with your regular routine.

Is there a way to avoid the side effects of Isosorbide dinitrate?

The best way to avoid the side effects of Isosorbide dinitrate is to take the medication exactly as directed by your doctor. Do not take more or less of it than what is prescribed. Also, it is important to inform your doctor or pharmacist of all the medications and supplements you are taking prior to taking Isosorbide dinitrate.

What should I do if I experience a symptom while taking Isosorbide dinitrate?

If you are taking Isosorbide dinitrate and experience any symptoms such as dizziness, headache, nausea, or low blood pressure, contact your doctor or pharmacist immediately. It is important to let your doctor or pharmacist know all the medications and supplements you are taking in order to prevent potential drug interactions.

How long should I continue to take Isosorbide dinitrate?

The duration of Isosorbide dinitrate treatment depends on the individual and the specific condition being treated. Talk to your doctor if you have any concerns about the length of your treatment.

Can I take Isosorbide dinitrate with other nitrate medications?

No, Isosorbide dinitrate should not be taken with other nitrate medications. Taking two nitrate medications together can cause a severe drop in your blood pressure. If you are already taking a nitrate medication, check with your doctor or pharmacist before taking Isosorbide dinitrate.

Does Isosorbide dinitrate cause a decrease in blood pressure?

Yes, Isosorbide dinitrate can cause a decrease in blood pressure. This is especially true when taken in combination with other medications that can lower blood pressure. Check with your doctor prior to taking Isosorbide dinitrate if you already take medications to lower your blood pressure.

Are there any laboratory tests that should be done while taking Isosorbide dinitrate?

No, there are no specific laboratory tests that should be done while taking Isosorbide dinitrate. That being said, it is important to keep all of your regularly scheduled check-ups and lab tests in order to monitor your condition.

Can Isosorbide dinitrate be used to treat high blood pressure?

While Isosorbide dinitrate is most commonly used to treat chest pain, it is sometimes used to treat high blood pressure. Talk to your doctor if you are considering taking Isosorbide dinitrate for this purpose.

Can Isosorbide dinitrate be used to treat other heart conditions?

Yes, Isosorbide dinitrate can be used to treat other heart conditions such as hypertension, aortic stenosis, and congestive heart failure. Talk to your doctor if you have any questions or concerns about using Isosorbide dinitrate to treat these conditions.

Can Isosorbide dinitrate interact with other drugs?

Yes, Isosorbide dinitrate can interact with other drugs, including certain medications, supplements, and alcohol. It is important to inform your doctor or pharmacist of all medications and supplements that you are taking prior to using Isosorbide dinitrate.

What are the storage requirements for Isosorbide dinitrate?

It is important to keep Isosorbide dinitrate in its original container and stored at room temperature. Keep out of reach of children and away from sources of excessive heat, light, and moisture.

Can Isosorbide dinitrate be taken if it has expired?

No, it is not recommended to take Isosorbide dinitrate if it has expired. If the expiration date on your medication has passed, contact your doctor or pharmacist for advice.

Can Isosorbide dinitrate be taken with other nitrate-containing medications?

No, it is not recommended to take Isosorbide dinitrate with other nitrate-containing medications. Taking two nitrate medications together can cause a severe drop in your blood pressure. Check with your doctor prior to taking Isosorbide dinitrate if you are already taking a nitrate medication.

Can Isosorbide dinitrate be taken with anti-anxiety medications?

Yes, Isosorbide dinitrate can be taken with most types of anti-anxiety medications. However, it is important to inform your doctor or pharmacist of all medications and supplements you are taking prior to using Isosorbide dinitrate, as certain medications may interact and increase the risk of side effects.

Is Isosorbide dinitrate available over-the-counter?

No, Isosorbide dinitrate is available only with a prescription from a doctor or other healthcare professional. Do not attempt to purchase Isosorbide dinitrate without a valid prescription.

What is the best time to take Isosorbide dinitrate?

The best time to take Isosorbide dinitrate depends on the particular form of the drug being used. Talk to your doctor or pharmacist for advice on the best time of day to take the medication.

Does Isosorbide dinitrate have any effects on the liver?

No, there is no evidence that Isosorbide dinitrate has any effects on the liver. However, it is important to let your doctor know

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