Sofosvel

Sofosvel Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Sofosvel is a brand name. Its generic name is Sofosbuvir + Velpatasvir.

Sofosvel

Introduction: Sofosvel is a combination antiviral therapy for the treatment of chronic hepatitis C (HCV) infections. It is a combination of two direct-acting antiviral agents, sofosbuvir and velpatasvir. Sofosbuvir is an inhibitor of RNA-dependent RNA polymerase and velpatasvir is an inhibitor of viral replication. The two agents work together to block essential functions of the virus thereby preventing its replication.

Uses

Sofosvel is used to treat chronic hepatitis C (HCV) infections in adults. It is approved by the U.S. Food and Drug Administration (FDA) to treat all six major HCV genotypes.

Mechanism of Action

Sofosvel works by blocking essential functions of the virus to prevent its growth. Sofosbuvir inhibits the replication of the virus by targeting the RNA-dependent RNA polymerase protein in the virus. Velpatasvir binds to the viral NS5A protein and inhibits the serine protease enzyme required for viral replication.

How Long Does it Take to Work?

Sofosvel usually begins working within 1-3 days. However, it may take up to 12 weeks or longer for the therapy to be fully effective.

Absorption

Sofosvel is rapidly absorbed after oral administration, with peak plasma concentrations occurring within 1-2 hours.

Route of Elimination

Sofosvel is metabolized in the liver, with the majority of the metabolites being excreted in the bile. Approximately 11-19% of the administered dose is eliminated in the urine.

Dosage

The recommended dosage of sofosbuvir + velpatasvir for the treatment of chronic hepatitis C (HCV) infections in adults is one tablet containing sofosbuvir 400 mg and velpatasvir 100 mg, taken orally once daily. The duration of treatment depends on the genotype of HCV infection, ranging from 8 to 12 weeks.

Administration

Sofosvel should be taken orally with or without food. It is recommended that it be taken at the same time each day, preferably at bedtime.

Side Effects

Common side effects of sofosbuvir + velpatasvir include: headache, fatigue, nausea, insomnia, and abdominal pain. Rare but serious side effects include: lactic acidosis, anemia, dizziness, and liver toxicity.

Toxicity

Sofosvel is generally well tolerated and has a low risk of toxicity. Most people tolerate treatment with sofosbuvir + velpatasvir without any major side effects or toxicity.

Precautions

Patients treated with sofosbuvir + velpatasvir should be monitored closely for signs and symptoms of liver toxicity. Patients should also be monitored for signs of other serious side effects, such as lactic acidosis or anemia. Women who are pregnant or breastfeeding should not take sofosbuvir + velpatasvir as it may cause harm to the fetus or newborn.

Interactions

Sofosbuvir + velpatasvir may interact with other medications, supplements, and vitamins. It is important to tell your doctor about all other medications, supplements, and vitamins you are taking before starting treatment with sofosbuvir + velpatasvir. Also, inform your doctor if you have any allergies or if you are pregnant or breastfeeding.

Disease Interactions

Patients with certain diseases should not take sofosbuvir + velpatasvir. These diseases include, but are not limited to, kidney or liver disease, and HIV.

Drug Interactions

Sofosbuvir + velpatasvir may interact with other drugs. It is important to tell your doctor about all other medications, supplements, and vitamins you are taking before starting treatment with sofosbuvir + velpatasvir. Common drugs that interact with sofosbuvir + velpatasvir include: heart and blood pressure medications, HIV protease inhibitors, anticonvulsants, vitamin K antagonists, and other antiviral medications.

Food Interactions

There are no known food interactions with sofosbuvir + velpatasvir. However, eating right before taking the medication may reduce its effectiveness.

Pregnancy Use

Sofosbuvir + velpatasvir should not be used during pregnancy. The safety and effectiveness of sofosbuvir + velpatasvir in pregnant women have not been established.

Lactation Use

breastfeeding mothers should not take sofosbuvir + velpatasvir as it is not known if the drug passes into breast milk.

Acute Overdose

If a person has overdosed on sofosbuvir + velpatasvir, they should seek emergency medical attention. Symptoms of an overdose can include nausea, vomiting, abdominal pain, and drowsiness.

Contraindication

Sofosbuvir + velpatasvir is contraindicated in patients with known hypersensitivity to the active ingredients or to any of the excipients in the product.

Use Directions

Sofosbuvir + velpatasvir should be taken orally once daily with or without food. It is recommended that it be taken at the same time each day, preferably at bedtime. Do not increase or decrease the dosage without consulting your doctor.

Storage Conditions

Store sofosbuvir + velpatasvir at room temperature away from heat, moisture, and direct light. Keep away from children and pets.

Volume of Distribution

The volume of distribution of sofosbuvir + velpatasvir is 1.13 - 2.12 liters per kilogram of body weight.

Therapeutic Half-Life

The therapeutic half-life of sofosbuvir + velpatasvir is 1-2 hours.

Clearance

Sofosbuvir + velpatasvir is metabolized in the liver and the metabolites are eliminated in the bile and urine. The clearance of sofosbuvir + velpatasvir is 17-30 liters per hour.

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