Skino

Skino Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Skino is a brand name. Its generic name is Benzoic Acid + Salicylic Acid.

Introduction

Benzoic acid and salicylic acid are two common organic acids found naturally in nature. Used in combination, these two acids possess many useful properties that have a wide range of applications from medicinal to industrial purposes.

Uses For

Benzoic acid and salicylic acid are used for a range of purposes in pharmaceuticals, food additives, cosmetics, and many more. It is also used as an antifungal for treating athlete’s foot, as an acne treatment, as an anti-dandruff treatment, and as an antiseptic and disinfectant.

Mechanism Of Action

The mechanism of action of benzoic acid and salicylic acid is complex and differs depending on the application. In general, both acids work by reducing the amount of oils in the skin, regulating the cell membrane of fungi, and killing bacterial and fungal cells.

How Long Does It Take To Work?

This depends on the specific application. Generally, acetylsalicylic acid requires up to several weeks to be fully effective while benzoic acid is usually more quickly effective, usually within days.

Absorption

Benzoic acid and salicylic acid are both absorbed through the skin. The penetration rate varies depending on the application.

Route Of Elimination

These two acids are eliminated from the body primarily through urine, although some may be eliminated through feces, sweat, and breath.

Dosage

The dosage of benzoic acid and salicylic acid depends on the application and the severity of the condition being treated. Common dosages include 10% topical salicylic acid 2-3 times a day, 0.2% benzoyl peroxide 1-2 times a day, and 1% topical benzoic acid once per day.

Administration

These acids are usually administered topically on the skin. Salicylic acid can also be taken orally by mouth.

Side Effects

Common side effects of benzoic acid and salicylic acid include skin irritation, dryness, burning sensation, and itching. Salicylic acid taken orally can cause nausea, vomiting, dizziness, and ringing in the ears.

Toxicity

The following toxicity levels of benzoic acid and salicylic acid has been established: Benzoic acid: LD50 (Lethal Dosage 50) = 3.6 g/kg (oral, rat) Salicylic acid: LD50 = 650 mg/kg (oral, rat)

Precaution

Benzoic acid and salicylic acid should be used with caution on people with sensitive skin or allergies as they can cause irritation. Salicylic acid should not be taken orally by pregnant women as it may be teratogenic (cause birth defects).

Interaction

Benzoic acid and salicylic acid may interact with some other medications. It is recommended to consult your doctor or pharmacist before using these acids if you are taking any other medications.

Disease Interaction

Benzoic acid and salicylic acid should be used with caution if you suffer from any skin diseases such as eczema or psoriasis as it can worsen these conditions.

Drug Interaction

Benzoic acid and salicylic acid may interact with certain medications such as aspirin, ibuprofen, and warfarin. It is recommended to consult your doctor or pharmacist before using these acids if you are taking any other medications.

Food Interactions

Benzoic acid and salicylic acid do not generally interact with foods, although they should be used with caution on people with food allergies.

Pregnancy Use

Benzoic acid and salicylic acid are generally considered safe to use during pregnancy when applied externally on the skin. However, salicylic acid should not be taken orally by pregnant women as it may be teratogenic (cause birth defects).

Lactation Use

Benzoic acid and salicylic acid are generally safe to use while nursing if applied externally on the skin.

Acute Overdose

Overdose of benzoic acid and salicylic acid may cause serious side effects such as confusion, fever, rapid or slow heartbeat, seizures, dizziness, drowsiness, and other symptoms. It is recommended to consult your doctor if you suspect an overdose.

Contraindication

Benzoic acid and salicylic acid should not be used by people with an allergy to either of these two acids and people who are taking medications that interact with them, such as aspirin, ibuprofen, and warfarin.

Use Direction

It is important to use benzoic acid and salicylic acid as directed by your doctor or pharmacist. Wash hands before and after applying the medications and avoid contact with eyes and face. Do not apply to any areas of broken or damaged skin.

Storage Condition

Benzoic acid and salicylic acid should be stored at room temperature away from direct sunlight. Do not freeze and keep them away from children and pets.

Volume Of Distribution

The volume of distribution of benzoic acid and salicylic acid depends on the application and the concentration of the medications.

Half Life

The average half life of benzoic acid and salicylic acid is approximately 3-4 hours.

Clearance

The clearance of benzoic acid and salicylic acid varies depending on the dosage, but generally it is about 150 ml/min.

Here you find in details version of Skino

Some Frequently Asked Questions About Skino

What are benzoic acid and salicylic acid?

Benzoic acid and salicylic acid are both organic acids that are commonly used as preservatives in a range of consumer products such as cosmetics, food, and medicines. Benzoic acid is a white crystalline solid and salicylic acid is an oil-soluble crystalline powder.

What are the chemical properties of benzoic acid?

Benzoic acid is a carboxylic acid derived from benzene. It is a weak acid with a pKa of 4.2, meaning that it is only slightly soluble in water. Its chemical formula is C7H6O2.

What are the uses of benzoic acid?

Benzoic acid is used in a variety of industries for a range of different applications. It is commonly used as a preservative and an antioxidant in food, making it an important part of food preservation. It may also be used to treat fungal infections, and as an intermediate in the synthesis of other chemicals.

What are the chemical properties of salicylic acid?

Salicylic acid is an aromatic acid with the molecular formula C7H6O3. It is a weak acid and is soluble in both water and organic solvents. Its pKa is 2.97, meaning that it is more soluble in water than benzoic acid.

What are the uses of salicylic acid?

Salicylic acid is commonly used as a key ingredient in topical acne products, due to its anti-inflammatory and skin-exfoliating properties. It has also been used to treat psoriasis, warts, and calluses, as well as being an ingredient in scar treatments, anti-dandruff shampoos, and skin lightening products.

How is benzoic acid produced?

Benzoic acid is most commonly produced through the catalytic oxidation of toluene. This process is carried out in an environment of high temperature and pressure, using an organic solvent to facilitate the reaction.

How is salicylic acid produced?

Salicylic acid is most commonly produced through the hydrolysis of methyl salicylate. This process involves the addition of acid to a solution of methyl salicylate in an organic solvent, resulting in the breakdown of the methyl salicylate into salicylic acid.

What is the difference between benzoic acid and salicylic acid?

The most notable difference between benzoic acid and salicylic acid is their solubility. Benzoic acid is a weak acid, and is only slightly soluble in water, while salicylic acid is a relatively strong acid, and is more soluble in both water and organic solvents.

Is benzoic acid safe?

Yes, benzoic acid is generally regarded as safe and it is approved by the Food and Drug Administration for use as a food preservative. However, it is important to note that prolonged exposure to high concentrations of benzoic acid can cause irritation and/or allergic reactions in some individuals.

Is salicylic acid safe?

Yes, salicylic acid is generally considered safe and is approved by the Food and Drug Administration for use as an active ingredient in over-the-counter acne medications. However, it is important to note that prolonged or excessive use of salicylic acid can cause irritation and/or allergic reactions in some individuals.

What are some of the side effects of benzoic acid?

Prolonged or excessive exposure to high concentrations of benzoic acid can cause irritation and/or allergic reactions in some individuals, including redness and itching of the skin. Additionally, it is important to note that benzoic acid may interact with certain medications and/or supplements. Therefore, it is always important to consult your physician before taking any form of benzoic acid.

What are some of the side effects of salicylic acid?

Prolonged or excessive use of salicylic acid can cause irritation and/or allergic reactions in some individuals, including redness, burning, and peeling of the skin. Additionally, it is important to note that salicylic acid may interact with certain medications and/or supplements. Therefore, it is always important to consult your physician before taking any form of salicylic acid.

Is benzoic acid toxic?

No, benzoic acid is generally regarded as safe and is approved by the Food and Drug Administration for use as a food preservative. However, it is important to note that prolonged or excessive exposure to high concentrations of benzoic acid may cause irritation and/or allergic reactions in some individuals.

Is salicylic acid toxic?

No, salicylic acid is generally considered safe and is approved by the Food and Drug Administration for use as an active ingredient in over-the-counter acne medications. However, it is important to note that prolonged or excessive use of salicylic acid may cause irritation and/or allergic reactions in some individuals.

What are the physical properties of benzoic acid?

Benzoic acid is a white crystalline solid with a melting point of 122°C and a boiling point of 249°C. It is slightly soluble in water, with a solubility of 0.25 g/L at 25°C.

What are the physical properties of salicylic acid?

Salicylic acid is an oil-soluble crystalline powder with a melting point of 158°C and a boiling point of 211°C. It is more soluble in water than benzoic acid, with a solubility of 0.7 g/L at 25°C.

What is the melting point of benzoic acid?

The melting point of benzoic acid is 122°C.

What is the boiling point of benzoic acid?

The boiling point of benzoic acid is 249°C.

What is the melting point of salicylic acid?

The melting point of salicylic acid is 158°C.

What is the boiling point of salicylic acid?

The boiling point of salicylic acid is 211°C.

Where can benzoic acid be found?

Benzoic acid can be found naturally in many foods, such as apples, berries, and cinnamon. It is also used as a preservative in many consumer products, such as cosmetics, food, and medicines.

Where can salicylic acid be found?

Salicylic acid can be found naturally in plants such as willow bark and sweet Birch. It is also used as an active ingredient in many skin care products, particularly those for treating acne and dandruff.

What is the structure of benzoic acid?

The structure of benzoic acid is C7H6O2, which can be represented as shown below:
benzoic acid structure

What is the structure of salicylic acid?

The structure of salicylic acid is C7H6O3, which can be represented as shown below:
salicylic acid structure

Is benzoic acid soluble in water?

Benzoic acid is a weak acid, and is only slightly soluble in water, with a solubility of 0.25 g/L at 25°C.

Is salicylic acid soluble in water?

Salicylic acid is a relatively strong acid, and is more soluble in water than benzoic acid, with a solubility of 0.7 g/L at 25°C.

Is benzoic acid polar?

Yes, benzoic acid is a polar molecule due to its asymmetrical structure and the presence of an oxygen atom with a partial negative charge. As such, it is capable of forming hydrogen bonds.

Is salicylic acid polar?

Yes, salicylic acid is a polar molecule due to its asymmetrical structure and the presence of an oxygen atom with a partial negative charge. As such, it is capable of forming hydrogen bonds.

How is benzoic acid used as a preservative?

Benzoic acid is a common food preservative, and it works by inhibiting the growth of fungi and bacteria. It is also used as an antioxidant to prevent fats from oxidizing and going rancid.

How is salicylic acid used as an acne treatment?

Salicylic acid is an active ingredient in many acne treatments, and works by loosening dead skin cells and unclogging pores. It also has anti-inflammatory properties that help reduce redness and inflammation.

Is benzoic acid flammable?

No, benzoic acid is not flammable and does not pose any significant fire risk.

Is salicylic acid flammable?

No, salicylic acid is not flammable and does not pose any significant fire risk.

What is the melting point range of benzoic acid?

The melting point range of benzoic acid is 122°C to 125°C.

What is the melting point range of salicylic acid?

The melting point range of salicylic acid is 158°C to 160°C.

What are the benefits of using benzoic acid as a preservative?

The primary benefit of using benzoic acid as a preservative is that it is effective at preventing the growth of fungi and bacteria. Additionally, it also has antioxidant properties, making it useful for preventing fats from going rancid.

What are the benefits of using salicylic acid as an acne treatment?

The primary benefit of using salicylic acid as an acne treatment is that it has both anti-inflammatory and skin-exfoliating properties. This makes it useful for reducing redness, inflammation, and unclogging pores.

What is the pKa of benzoic acid?

The pKa of benzoic acid is 4.2.

What is the pKa of salicylic acid?

The pKa of salicylic acid is 2.97.

What are the difference in solubility between benzoic acid and salicylic acid?

Benzoic acid is a weak acid, and is only slightly soluble in water, with a solubility of 0.25 g/L at 25°C. Salicylic acid is a relatively strong acid, and is more soluble in both water and organic solvents, with a solubility of 0.7 g/L at 25°C.

What is the difference between benzoic acid and salicylic acid in terms of chemical properties?

The most notable difference between benzoic acid and salicylic acid is their solubility. Benzoic acid is a weak acid, and is only slightly soluble in water, while salicylic acid is a relatively strong acid, and is more soluble in both water and organic solvents.

Is prolonged exposure to benzoic acid dangerous?

Prolonged or excessive exposure to high concentrations of benzoic acid can cause irritation and/or allergic reactions in some individuals. Therefore, it is important to be aware of potential health risks and take necessary precautions when handling