Sertralina, a brand name for a formulation containing essential Sertraline, is widely used for various health benefits. This guide provides comprehensive information on the uses, dosage, side effects, and mechanism of action of Sertralina, as well as insights into how long it takes to work. Understanding these aspects can help you make informed decisions about its use and effectiveness.


Sertralina is the generic name for the brand name drug Zoloft, a medication usually prescribed to treat depression, panic disorder, or post-traumatic stress disorder (PTSD). It belongs to the group of drugs called selective serotonin reuptake inhibitors (SSRIs). Sertralina works by increasing the amount of serotonin, a natural chemical present in the brain that helps maintain mental balance.


The Food and Drug Administration (FDA) approves the use of Sertralina in adults for:

  • Depression
  • Obsessive-compulsive disorder (OCD)
  • Panic disorder
  • Post-traumatic stress disorder (PTSD)
  • Premenstrual dysphoric disorder (PMDD)

Mechanism of Action

Sertralina works by inhibiting the reuptake of serotonin in the brain, allowing the serotonin to stay in the synapse longer and thus increasing its effectiveness. By doing so, it increases the level of serotonin in the brain, making the patient feel happier and better balanced.

How Long Does it Take to Work?

It takes several weeks for sertraline to take full effect. Most people start off with smaller doses like 25 mg and slowly move up to higher doses over the course of a few weeks. It may take as long as two to three months for people to experience the full benefit of sertraline.


Sertralina is rapidly and well-absorbed in the gastrointestinal tract. It is absorbed with an absolute bioavailability of greater than 90 percent, and its peak plasma concentration is reached in one to four hours.

Route of Elimination

Sertralina is mainly excreted in the urine as metabolites. Its elimination half-life is approximately 26 hours, which means that the drug will be eliminated from the body in about two days.


The recommended dose of sertraline is 50-200 mg per day taken orally. The dose may be increased or decreased depending on the patient's symptoms or response. The average dose is typically 100-150 mg per day taken once daily in the morning or evening.


Sertralina is available in the form of tablets, capsules, and liquid form. It should be taken orally with or without food. It is important to take sertraline regularly at the same time each day to get the most benefit.

Side Effect

Common side effects of sertraline include nausea, vomiting, diarrhea, dry mouth, drowsiness, fatigue, dizziness, agitation, headache, tremor, sexual dysfunction, sweating, and blurred vision. Rare side effects include allergic reaction, fever, muscle spasms, confusion, convulsions, Stevens-Johnson syndrome, and increased risk of serotonin syndrome.


Sertralina is an overdose-proof drug and is not associated with any significant toxicity unless taken in extremely large doses. If an overdose is suspected, the patient should be evaluated immediately.


Patients taking sertraline should avoid drinking alcohol as it may increase the risk of side effects. It should not be used with other drugs that can cause serotonin syndrome, including MAOI’s, tricyclic antidepressants, and certain antipsychotics. It should also be used with caution in patients with pre-existing conditions such as high blood pressure, seizures, or liver or kidney disease.


Sertralina may interact with other medicines, vitamins, and herbal products. Therefore, it is important to tell your healthcare provider about any medications you are currently taking. Common drug interactions include MAO inhibitors, tricyclic antidepressants, and non-steroidal anti-inflammatory drugs (NSAIDs).

Disease Interaction

Sertralina may interact with certain diseases, such as seizures, bipolar disorder, kidney or liver disease, and pregnancy. Therefore, it's important to tell your doctor about any existing conditions you have.

Drug Interaction

Sertralina may interact with certain drugs, such as monoamine oxidase inhibitors (MAOIs), tricyclic antidepressants, atypical antipsychotics and certain medications for migraine headaches. Therefore, it's important to tell your healthcare provider about any medications you are currently taking.

Food Interactions

Sertralina should not be taken with certain foods as the combination may result in decreased efficacy and increased side effects. Foods that should be avoided include high-fat foods like nuts and avocados, alcohol, and grapefruit or grapefruit juice.

Pregnancy Use

Sertralina is generally avoided during pregnancy. However, if there is the potential benefit outweighing the potential risk, sertraline may be prescribed. The risks and benefits should be discussed with your healthcare provider before starting sertraline.

Lactation Use

Sertralina is excreted in breast milk and is not recommended for nursing mothers. If sertraline is necessary, breastfeeding should be discontinued.

Acute Overdose

The symptoms of an acute overdose of sertraline usually include nausea, vomiting, and drowsiness. Other symptoms, such as seizures, coma, and death, may occur with higher doses. If an overdose is suspected, medical attention should be sought immediately.


Sertralina is contraindicated in patients with known hypersensitivity to its components, and patients with concurrent use of monoamine oxidase inhibitors (MAOIs). It should also not be used in patients with severe liver impairment, electrolyte rebalance, and in children and adolescents under the age of 18.

Use Direction

Sertralina should be taken exactly as directed by a healthcare provider. Dosage instructions and other information should be followed precisely to reduce the risk of side effects and to ensure optimal results. It should also be taken at the same time every day.

Storage Condition

Sertralina should be stored at room temperature, away from moisture, heat, and light. Keep it tightly closed and out of reach of children.

Volume of Distribution

The approximate volume of distribution of sertraline is 12 liters per kilogram.

Half Life

Sertralina has a half-life of about 26 hours.


The metabolic clearance of sertraline is about 0.23 liters per hour per kilogram.

Here you find in details version of Sertralina,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,