Sensimet DS

Sensimet DS Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Sensimet DS is a brand name. Its generic name is Rosiglitazone + Metformin.

Introduction

Sensimet DS (ERGAMIN CP TO) is a combination of two drugs, an anti-diabetic medication (rosiglitazone) and an antidiabetic drug (metformin). It is used to treat type 2 diabetes mellitus along with proper diet and exercise.

Uses

Sensimet DS is used in the treatment of type 2 diabetes mellitus. It works by decreasing the amount of sugar that is absorbed in the intestines and increasing the body's sensitivity to insulin. It can also help prevent or delay the development of diabetic complications such as nerve, kidney, and eye damage.

Mechanism of Action

Rosiglitazone belongs to the class of drugs known as thiazolidinediones (TZDs). It works by activating the nuclear receptors - PPAR gamma, which stimulates the uptake of glucose by the cells. It also improves the insulin sensitivity of the peripheral tissues.

Metformin belongs to the class of drugs known as biguanides. It works by decreasing the production of glucose by the liver, and increasing the absorption of glucose by the cells and tissues of the body. It inhibits the enzyme glucokinase, which is responsible for the conversion of glucose into its storage form, glycogen.

How Long Does It Take To Work?

Sensimet DS usually starts working in 2-4 weeks. However, it may take up to 8 weeks to see the full benefits of the drug.

Absorption

Rosiglitazone is absorbed well in the gastrointestinal tract. Metformin is not well absorbed, however, it is slowly released from the tablets.

Route of Elimination

Rosiglitazone is eliminated from the body primarily by the liver. Metformin is eliminated mainly through the kidneys.

Dosage

The usual starting dose of Sensimet DS is one tablet twice daily, before meals. The maximum recommended dose is two tablets twice daily before meals. The dosage should be adjusted based on the patient's response to the therapy.

Administration

Sensimet DS should be taken orally, with or without food. It should be taken at the same time every day, with or without food.

Side Effect

Common side effects of Sensimet DS include nausea, headache, diarrhea, abdominal pain, and altered taste. Other side effects include an increase in body fat, constipation, dizziness, weakness, confusion, and irregular heartbeat.

Toxicity

A high dosage of Sensimet DS may lead to serious side effects such as lactic acidosis. Signs of lactic acidosis include increased heart rate, decreased breathing, abdominal and muscle pain, stomach cramps, and feeling cold.

Precautions

Before taking Sensimet DS, it is important to discuss your medical history and current medications with your healthcare provider. Tell your provider if you are pregnant, planning to become pregnant, or breastfeeding. Also tell your provider if you have any kidney or liver problems, heart problems, or a history of allergies to medicines.

Interaction

Sensimet DS may interact with other medications, including but not limited to insulin, steroids, antibiotics, HIV drugs and migraine medications. It is important to tell your doctor about all medications you are taking, including over-the-counter drugs and supplements.

Disease Interaction

Sensimet DS may interact with certain diseases or medical conditions such as kidney problems, liver problems, congestive heart failure, and diabetes. It is important to provide your healthcare provider with a list of all preexisting medical conditions and diseases before taking this medication.

Drug Interaction

Sensimet DS may interact with certain other drugs, including antibiotics, antifungal drugs, HIV drugs, hypertension medications, and cholesterol lowering medications. It is important to tell your doctor about all medications you are taking, including over-the-counter drugs and dietary supplements.

Food Interactions

Sensimet DS may interact with certain food items such as alcohol, caffeine, certain vitamins, and certain fruits and vegetables. It is important to discuss all dietary modifications with your healthcare provider before taking this medication.

Pregnancy Use

Sensimet DS should be avoided during pregnancy unless medically necessary. It is not known if the drug passes into breast milk so breastfeeding should be avoided while taking this drug.

Lactation Use

Sensimet DS should be avoided during lactation unless medically necessary. It is not known if the drug passes into breast milk so breastfeeding should be avoided while taking this drug.

Acute Overdose

An acute overdose of Sensimet DS may result in increased blood sugar, nausea, vomiting, abdominal pain, and decreased appetite. If you suspect an overdose, it is important to get medical help immediately.

Contraindications

Sensimet DS is contraindicated in patients with type 1 diabetes mellitus, in diabetic ketoacidosis, and in patients with a history of lactic acidosis. It should also not be taken with certain medications such as low-dose aspirin, paracetamol, opioid painkillers, antacids, and certain antibiotics.

Use Direction

Sensimet DS should be taken as directed by your healthcare provider. It is important to take the medication at the same time every day, with or without food. Do not take more or less than the amount prescribed to you.

Storage Condition

Sensimet DS should be stored at room temperature, away from moisture and heat. Keep the medication out of the reach of children and away from pets.

Volume of Distribution

The volume of distribution of Sensimet DS is unknown.

Half Life

The half-life of Rosiglitazone is about 5 hours, whereas the half-life of Metformin is about 8 hours.

Clearance

The clearance of Rosiglitazone is about 2.5 mL/min/kg, while the clearance of Metformin is about 1 mL/min/kg.

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