Semglee Prefilled Pen

Semglee Prefilled Pen, a brand name for a formulation containing essential Insulin glargine, is widely used for various health benefits. This guide provides comprehensive information on the uses, dosage, side effects, and mechanism of action of Semglee Prefilled Pen, as well as insights into how long it takes to work. Understanding these aspects can help you make informed decisions about its use and effectiveness.

Insulin Glargine

Semglee Prefilled Pen is a long-acting insulin analogue used to help treat adult and pediatric patients with diabetes. This medication is designed to provide a more constant level of insulin in the body compared to other forms of insulin. It is used to help regulate blood sugar levels and improve glycemic control. Semglee Prefilled Pen helps to reduce the risk of complications such as heart disease, kidney failure, and blindness associated with diabetes.


Semglee Prefilled Pen is primarily used in people with type 1 diabetes or type 2 diabetes who do not achieve adequate glycemic control with other forms of insulin. It is typically used in combination with faster-acting insulins for maximum glycemic control. It can also be used alone to treat diabetes.

Mechanism of Action

Semglee Prefilled Pen works by binding to and activating the insulin receptor. This triggers the body to take up glucose (sugar) from the blood and store it in the form of glycogen in the liver and muscle cells, which lowers the amount of glucose in the blood. Semglee Prefilled Pen also helps to reduce production of glucose by the liver while increasing its use in other cells, which further helps reduce blood glucose levels.

How Long Does It Take to Work?

Semglee Prefilled Pen typically begins working in 6-14 hours. It reaches peak effects around 24 hours, and its effects may last up to 36 hours.


Semglee Prefilled Pen is designed to be slowly absorbed, providing a more constant level of insulin in the body. It is typically absorbed over a period of 12-24 hours.

Route of Elimination

Semglee Prefilled Pen is eliminated from the body through urine.


The usual starting dose of insulin glargine is 0.2 unit/kg body weight per day. The dose is increased by adding small increments of 0.1-0.2 units/kg per day until the desired glycemic control is achieved. The dose can further be adjusted as needed according to blood glucose levels.


Semglee Prefilled Pen is typically taken once per day by injection. It should be injected in the same spot every day to ensure consistent absorption.

Side Effect

Common side effects of insulin glargine include weight gain, injection site reactions, nausea, vomiting, diarrhea, headache, hypoglycemia (low blood sugar), fatigue, muscle weakness and joint pain.


Semglee Prefilled Pen is generally well-tolerated with few serious side effects. Overdose is possible but very rare, and its symptoms include hypoglycemia, coma, and cardiovascular collapse. Overdose of insulin glargine should be treated with a rapid-acting glucose source, such as intravenous dextrose.


Before taking insulin glargine, patients should tell their doctor about any other medications they may be taking and if they have any other medical conditions. Patients should also inform their doctor of recent changes in diet or activity levels. It is important to check blood sugar levels regularly when taking this medication.


Semglee Prefilled Pen may interact with other medications, such as certain drugs used to treat diabetes, thyroid drugs, diuretics, antibiotics, antifungal medications, and oral contraceptives. It can also interact with certain herbs and supplements, including garlic, ginseng, and omega-3 fatty acids.

Disease Interaction

Semglee Prefilled Pen can interact with certain diseases, such as kidney disease, liver disease, heart failure, and atherosclerosis. It may also interact with certain conditions, such as dehydration, fever, and infection.

Drug Interaction

Patients should inform their doctor of any other medications they are taking before taking insulin glargine, as certain medications may increase or decrease its effects. These medications include certain drugs used to treat diabetes, diuretics, antibiotics, antifungal medications, and oral contraceptives.

Food Interactions

Food can interact with insulin glargine, mainly by increasing the risk of hypoglycemia (low blood sugar). Patients should discuss their diet with their doctor before taking this medication.

Pregnancy Use

Semglee Prefilled Pen is classified as a pregnancy category C medication, meaning it may be harmful to the fetus and should only be used during pregnancy if the benefits to the mother outweigh the potential risks to the baby. It is advised to avoid breastfeeding while taking insulin glargine.

Lactation Use

It is not known if insulin glargine passes into breast milk. It is recommended that mothers do not breastfeed while taking this medication.

Acute Overdose

An acute overdose of insulin glargine can be dangerous and should be treated as a medical emergency. Symptoms of an overdose can include hypoglycemia, coma, and cardiovascular collapse.


Semglee Prefilled Pen should not be used in patients with hypersensitivity to insulin glargine or any of its components. It should also not be used in patients who have a history of diabetic ketoacidosis or other conditions associated with acidosis.

Use Direction

It is important to follow the directions of a healthcare provider when taking insulin glargine. Take the prescribed dose as directed and discuss any adjustments or changes with a healthcare provider.

Storage Condition

Semglee Prefilled Pen should be stored at room temperature and must NOT be refrigerated or frozen. Keep this medication away from direct light and heat, and do NOT shake the vial or use a vial that has been frozen.

Volume of Distribution

The volume of distribution of insulin glargine is approximately 0.12 L/kg.


The half-life of insulin glargine is up to 24 hours.


The clearance of insulin glargine is approximately 0.2 L/h/kg.

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