Selexid Tablet

Brand Name: Selexid
Generic: Pivmecillinam
Weight: 200 mg
Type: Tablet
Therapeutic Class: Mecillinams
Manufacturer: Leo Pharmaceutical Ltd, Denmark
Price: 32.87
Last Updated: 2020-11-21 18:15:00

Selexid Tablet Uses

Selexid Tablet contains Pivmecillinam. Selexid uses:

Selexid Tablet is indicated for treatment of infections caused by mecillinam-sensitive organisms, e.g. acute cystitis, complicated urinary tract infections, salmonellosis, shigellosis, enteropathic E. coli diarrhoea, gram-negative septicaemia, billiary infections.

Selexid Tablet Doses

Selexid Tablet contains Pivmecillinam 200 mg. Selexid doses:


  • The usual dose: 1-2 tablets 3 times daily according to severity of the infection.
  • In acute uncomplicated cystitis: initially 400 mg then 200 mg every 8 hours for 3 days.
  • In chronic or recurrent bacteriurea: 400 mg 6-8 hours.
  • For the treatment of salmonellosis (including enteric fever): 1.2-2.4 gm daily for 14 days. To eliminate salmonella carriage, therapy may be prolonged for 2-4 weeks. In complicated urinary tract infection the usual treatment time is 1-2 weeks.
  • For prophylactic treatment of recurrent urinary tract infections: 1 tablet every evening is recommended.


  • Weighing less than 20 kg should be given 20-60 mg/kg divided into 3-4 daily doses. Those weighing more than 20 kg should receive normal adult dose.
  • In shigellosis: 20 mg/kg 4 times a day for 5 days.
  • For UTI: 20-40 mg/kg/day in 3-4 divided doses
  • For salmonellosis: 30-60 mg/kg/day in 3-4 divided doses

The tablet should be taken with at least 50-100 ml fluid. As the bioavailability is practically unaffected by simultaneous food intake, This tablets are best taken with or immediately after a meal.

Side Effects

Selexid Tablet is generally well tolerated, even by patients with reduced kidney function. Upper gastrointestinal disturbances such as nausea, vomiting and diarrhoea or indigestion may occur when a dose has been given on an empty stomach. Skin rashes have been reported in some cases, but the characteristic ampicillin-rash has never been observed, nor has there been any evidence of hepato-, nephro-, or ototoxicity. The occurrence of anaphylaxis, though not yet reported, cannot be entirely excluded.


Selexid Tablet belongs to a new class of penicillin-the amdinopenicillin. Selexid Tablet is a prodrug formulation of mecillinam which allows the drug to be administered by mouth. The prodrug form lacks antibacterial activity, but the active drug is liberated by enzymatic hydrolysis during absorption in the gastrointestinal tract.

Selexid Tablet is bactericidal. It acts by interfering with bacterial cell wall synthesis, but the site of action differs from that of other penicilins. Selexid Tablet is very active against Enterobacteriaceae. It is active against E. coli, Klebsiella, Proteus, Enterobacter, Salmonella, Shigella and Yersinia. Selexid Tablet has poor activity against Gram- positive organisms. It has poor activity against Pseudomonas aeruginosa and has practically no activity against Enterococcus faecalis.

Selexid Precaution

There is no experience with over dosage of pivmecillinam. However, excessive doses are likely to cause nausea, vomiting and gastritis. Treatment should be restricted to symptomatic and supportive measures. If necessary haemodialysis will reduce the blood level.



Pregnancy Lactation use

Mecillinam concentrations approximately 1/3 of the serum levels have been found in the umbilical cord, and low but detectable amounts in the amniotic fluid. So, use of pivmecillinam in pregnancy should be avoided. Mecillinam is not excreted into the milk of lactating mother


There have been no reports on allergy to Selexid Tablet among patients with a known history of hypersensitivity to penicillins and cephalosporins. Nevertheless, it seems reasonable to exclude such patients from treatment with Selexid Tablet until further experience has been gained.

Special Warning

Based on information available to date for patients with impaired renal function, the initial dose can remain unchanged as can the interval between doses. However, the amount administered as the maintenance dose should be changed according to the following criteria:

  • CrCl 30 ml/min or greater: full dosage
  • CrCl 10-30 ml/min: 50% dosage
  • CrCl <10 ml/min: 25% dosage

Use of Selexid Tablet in infants under 3 months of age should be avoided.

Acute Overdose


Interaction with other Medicine


Storage Condition

Store at a cool and dry place, protect from light and moisture.

Selexid Tablet price in Bangladesh 32.87