Sefrate

Sefrate Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Sefrate is a brand name. Its generic name is Cefradine.

Introduction

Sefrate is an antibiotic drug commonly used for treatment of infections caused by bacteria. It is a first-generation cephalosporin and belongs to the class of cephalosporins. It is a semi-synthetic antibiotic, which means that it has been made in a laboratory from natural substances.

Uses for

Sefrate is used to treat a variety of infections, including but not limited to respiratory infections, skin infections, chest infections, urinary tract infections, and some sexually transmitted diseases.

Mechanism of Action

Sefrate works by inhibiting the bacteria's ability to make proteins which are an important part of its structure, function, and multiplication. By inhibiting this process, cefradine is able to kill the bacteria and prevent it from multiplying.

How Long Does it Take to Work?

Sefrate usually starts to work within a few hours of taking the medication. However, depending on the type of infection being treated, it can take up to several days before the symptoms start to clear up.

Absorption

Sefrate is mostly absorbed from the gastrointestinal tract, with the exception of the dose taken rectally. The majority of an oral dose is absorbed within 3 hours, with peak plasma concentrations occurring after 4-6 hours.

Route of Elimination

Sefrate is eliminated largely from the urine as the unchanged form. Some is also excreted in the feces via biliary excretion. The half-life is in the range of 1-2 hours.

Dosage

Sefrate is available in the form of tablets, capsules, and soluble tablets. The usual adult dosage ranges from 500mg to 1000mg twice daily, depending on the severity of the infection being treated.

Administration

Sefrate should be taken orally with a glass of water, preferably one hour before or two hours after meals, or as directed by the healthcare provider. It is important not to take cefradine with food as this interferes with absorption. For rectal administration, the dose should be dissolved in a small amount of water.

Side Effect

Common side effects of cefradine include nausea, vomiting, abdominal pain, diarrhea, skin rash, oral thrush, and vaginal itching. More serious side effects include anemia, jaundice, fever, and seizures.

Toxicity

Sefrate is generally safe and well tolerated at the recommended dosage. Overdose can lead to symptoms such as renal failure, seizures, and blood disorders.

Precautions

Sefrate should be used with caution in patients with liver or kidney disease, and in those taking other medications such as anticoagulants, oral contraceptives, and diuretics. It should also be used with caution in pregnant and breastfeeding women.

Interactions

Sefrate may interact with other drugs and should not be taken in combination with other antibiotics, sedatives, or anticoagulants. It also interacts with some herbs and supplements, including ginkgo biloba, garlic, and St. John's Wort.

Disease Interaction

Sefrate has been known to interact with certain diseases, including kidney and liver disease, which may affect its effectiveness or cause side effects. It may also interact with other diseases, such as diabetes, which can alter its metabolism and increase its potential for side effects.

Drug Interactions

Sefrate may interact with other drugs including anticoagulants, oral contraceptives, and diuretics. Taking cefradine simultaneously with these drugs may increase the risk of side effects. Additionally, cefradine may increase the risk of bleeding when taken with other drugs that increase blood clotting time.

Food Interactions

Sefrate should be taken one hour before or two hours after meals. Taking it simultaneously with food may reduce its effectiveness. It should also not be taken with dairy products, including milk, cheese, and yogurt, as this may reduce its absorption rate.

Pregnancy Use

Sefrate should be used with caution in pregnant women. There is limited evidence regarding the safety of cefradine during pregnancy. If used, the lowest effective dosage should be used for the shortest duration possible.

Lactation Use

Sefrate should be avoided during lactation as it is excreted in breast milk. If it must be used, the lowest effective dosage should be used for the shortest duration possible.

Acute Overdose

If an overdose is suspected, the patient should be taken to the doctor or hospital immediately. Symptoms of an overdose include nausea, vomiting, abdominal pain, drowsiness, convulsions, and sweating.

Contraindication

Sefrate is contraindicated in patients with a known hypersensitivity to cephalosporins or penicillins. It is also contraindicated in patients with severe renal or hepatic impairment, and in those who have had a previous episode of either anaphylactic or anaphylactoid reactions.

Use Direction

Sefrate should always be taken as prescribed by the doctor. The dosing frequency and duration of treatment should not be altered without consulting the healthcare provider.

Storage Condition

Sefrate should be stored at room temperature in a closed container, away from moisture and direct sunlight. Keep out of reach of children and pets.

Volume of Distribution

Sefrate has a volume of distribution of 0.3-0.6 L/kg indicating a low penetration into tissues.

Half Life

The elimination half-life of cefradine is in the range of 1-2 hours.

Clearance

Sefrate is mainly eliminated by the kidneys with an average clearance of 250mL/min.

Here you find in details version of Sefrate

Some Frequently Asked Questions About Sefrate

What is Sefrate?

Sefrate is a type of antibiotic medicine that is used to treat bacterial infections.

How does Sefrate work?

Sefrate works by preventing bacteria from forming cell walls, which are necessary for the bacteria to survive and grow.

What type of infections can Sefrate treat?

Sefrate is used to treat bacterial infections such as skin and soft tissue infections, urinary tract infections, and respiratory tract infections.

Who should not take Sefrate?

Sefrate should not be taken by people who are allergic to cephalosporin antibiotics. People with kidney, liver, or intestinal disease should consult a doctor before taking this medicine.

What are the possible side effects of Sefrate?

The most common side effects of Sefrate are nausea, vomiting, diarrhea, skin rash, and headache.

Is Sefrate safe to take during pregnancy?

Sefrate is generally considered safe to take during pregnancy, however it is recommended that pregnant women should consult their doctor before taking it.

What should I do if I experience any side effects from Sefrate?

If you experience any side effects, you should stop taking the medication and consult your doctor immediately.

How and when should I take Sefrate?

Sefrate should be taken with food or a full glass of water/milk. The amount and duration of treatment will depend on the type and severity of your infection.

What should I do if I miss a dose of Sefrate?

If you miss a dose of Sefrate, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule.

Is it safe to consume alcohol while taking Sefrate?

It is not recommended to consume alcohol while taking Sefrate as it may increase the risk of side effects such as nausea, dizziness, drowsiness, and reduced alertness.

Can I take other medicines while taking Sefrate?

Some medicines may interact with Sefrate and it is recommended to consult your doctor before taking any other medication.

Can Sefrate be used for children?

Sefrate can be used for children but it is important to consult a doctor before giving this medicine to a child.

Are there any foods I should avoid while taking Sefrate?

No, you do not need to avoid any specific foods while taking Sefrate.

How long does it take for Sefrate to work?

It may take up to 2 weeks for Sefrate to work and start relieving symptoms.

Can I stop taking Sefrate once I start to feel better?

No, it is important to continue taking Sefrate until you have finished the course of medication prescribed by your doctor.

What should I do if I am taking Sefrate and experience a fever?

If you experience a fever while taking Sefrate, you should contact your doctor as soon as possible.

Does Sefrate interact with birth control pills?

Yes, Sefrate may interact with birth control pills. It is recommended to consult your doctor for advice.

Does Sefrate interact with other antibiotics?

Yes, some antibiotics may interact with Sefrate. It is recommended to consult your doctor for advice before taking any other medication.

Should I take Sefrate with food or on an empty stomach?

Sefrate should be taken with food or a full glass of water/milk.

Can Sefrate be used to treat a sore throat?

Yes, Sefrate is used to treat sore throat caused by bacterial infections.

Can I take Sefrate to prevent an infection?

No, Sefrate should not be taken as a preventative measure against infections.

Is Sefrate affected by hot weather?

No, Sefrate is not affected by hot weather.

Can Sefrate be taken with vitamin supplements?

Yes, Sefrate can be taken with vitamin supplements, however it is recommended to consult your doctor before taking any additional supplements.

What should I do if I experience an allergic reaction to Sefrate?

If you experience an allergic reaction to Sefrate, stop taking the medication and contact your doctor immediately.

Can I take Sefrate with antacids?

Yes, Sefrate can be taken with antacids, however it is recommended to consult your doctor for advice.

Can I take Sefrate if I am breastfeeding?

It is not recommended to take Sefrate while breastfeeding, however it is recommended to consult your doctor for advice.

Can I take Sefrate while menstruating?

Yes, you can take Sefrate while menstruating.

What should I do if I experience nausea after taking Sefrate?

If you experience nausea after taking Sefrate, it is recommended to consult your doctor for advice.

Can Sefrate interact with other medications?

Yes, some medications may interact with Sefrate and it is recommended to consult your doctor before taking any other medication.

What should I do if I experience vomiting after taking Sefrate?

If you experience vomiting after taking Sefrate, it is recommended to consult your doctor for advice.

Can I take Sefrate if I am diabetic?

Yes, Sefrate can be taken if you are diabetic, however it is recommended to consult your doctor for advice.

Can I take Sefrate if I have a kidney condition?

Yes, Sefrate can be taken if you have a kidney condition, however it is recommended to consult your doctor for advice.

Can I take Sefrate if I have a liver condition?

Yes, Sefrate can be taken if you have a liver condition, however it is recommended to consult your doctor for advice.

Is there any age restriction for taking Sefrate?

No, there is no age restriction for taking Sefrate, however it is recommended to consult your doctor for advice.

Can Sefrate cause dizziness?

Yes, Sefrate can cause dizziness, and it is recommended to consult your doctor if you experience this symptom.

Can Sefrate cause drowsiness?

Yes, Sefrate can cause drowsiness, and it is recommended to consult your doctor if you experience this symptom.

Can Sefrate cause dehydration?

Yes, Sefrate can cause dehydration, and it is recommended to consult your doctor if you experience this symptom.

Can Sefrate cause reduced alertness?

Yes, Sefrate can cause reduced alertness, and it is recommended to consult your doctor if you experience this symptom.

Can Sefrate cause a burning sensation?

Yes, Sefrate can cause a burning sensation, and it is recommended to consult your doctor if you experience this symptom.

Can Sefrate cause headaches?

Yes, Sefrate can cause headaches, and it is recommended to consult your doctor if you experience this symptom.

Can Sefrate cause stomach cramps?

Yes, Sefrate can cause stomach cramps, and it is recommended to consult your doctor if you experience this symptom.