Romazine, a brand name for a formulation containing essential Chlorpromazine, is widely used for various health benefits. This guide provides comprehensive information on the uses, dosage, side effects, and mechanism of action of Romazine, as well as insights into how long it takes to work. Understanding these aspects can help you make informed decisions about its use and effectiveness.


Romazine is a drug that belongs to the phenothiazine class of antipsychotic medications. It is used to treat conditions such as anxiety, bipolar disorder, psychosis, and schizophrenia. It is also used to help control nausea and vomiting and as a sedative.


Romazine is used to treat a wide range of mental health conditions. It is most commonly prescribed for psychotic disorders such as schizophrenia, and can also be used to treat symptoms of bipolar disorder, depression, and anxiety. Romazine is also used to treat nausea and vomiting, and as a sedative to help with sleep problems related to mental health disorders.

Mechanism of Action

Romazine works by interacting with brain receptors known as dopamine receptors. This interaction reduces the amount of dopamine which is a brain chemical that controls behavior and emotions. By reducing the amount of dopamine in the brain, chlorpromazine can help to reduce the symptoms of psychotic disorders and help to stabilize mood.

How Long Does it Take to Work?

The effects of chlorpromazine can be felt quickly, usually within 2-3 days of starting treatment. It can take up to 6 weeks for the full effects of chlorpromazine to be felt.


Romazine is rapidly and completely absorbed from the digestive tract following oral administration. It is then widely distributed throughout the body.

Route of Elimination

Romazine is metabolized by the liver before being eliminated from the body primarily in urine.


The recommended dosage of chlorpromazine for adults and adolescents 16 years of age and older is generally 25 mg three times a day. Doses may be adjusted by a healthcare provider depending on the patient’s symptoms.


Romazine is usually taken orally in the form of tablets or an oral solution. The tablets can be taken with or without food.

Side Effects

Common side effects of chlorpromazine may include drowsiness, dry mouth, constipation, blurred vision, and changes in appetite and weight. More serious side effects may include low blood pressure and high risk of seizures.


Romazine can be toxic if taken in large doses. Symptoms of toxicity may include confusion, mental changes, muscle weakness, and slowed breathing.


Romazine carries a risk of serious side effects and should be used with caution in elderly, pregnant, and nursing patients. Patients should also be monitored for potential changes in behavior or emotional status.


Romazine may interact with certain medications, particularly anticoagulants and drugs that suppress the central nervous system. Patients should avoid alcohol while taking chlorpromazine. Consult a healthcare professional before taking any medication with chlorpromazine.

Disease Interactions

Romazine may interact with certain diseases such as glaucoma, heart disease, and thyroid problems. Patients with these conditions should consult a doctor before taking chlorpromazine.

Drug Interactions

Romazine may interact with certain drugs such as antipsychotics, antiepileptics, narcotics, and tricyclic antidepressants. Patients should consult a doctor before taking chlorpromazine.

Food Interactions

Romazine should be taken with food or milk to reduce the risk of stomach upset.

Pregnancy Use

Romazine should not be used during pregnancy as it may be harmful to the growing fetus.

Lactation Use

Romazine is excreted in breast milk and should be avoided while breastfeeding.

Acute Overdose

Signs of an acute overdose of chlorpromazine include drowsiness, confusion, slowed breathing, and an uneven heart rate. Patients should seek emergency medical attention if they think they may have overdosed on chlorpromazine.


Romazine use is contraindicated in patients with a history of certain medical conditions such as glaucoma, heart disease, liver or kidney disease, and thyroid disease.

Usage Direction

Romazine should be taken only as directed by a healthcare provider. Patients should follow the directions on the label and not take more than the recommended dose.

Storage Condition

Romazine should be stored at room temperature in a dry place away from direct sunlight.

Volume of Distribution

Romazine has a volume of distribution of approximately 1.4 L/kg.

Half Life

The half life of chlorpromazine is approximately 30 hours.


The clearance of chlorpromazine is approximately 30 mL/min/kg.

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