Rolage

Rolage Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Rolage is a brand name. Its generic name is Raloxifene.

Rolage Introduction

Rolage is a selective estrogen receptor modulator (SERM), also known as a “designer estrogen,” approved for use in postmenopausal women for both the prevention and treatment of osteoporosis and for decreasing the risk of breast cancer. It works by competing with estradiol for binding sites on the estrogen receptor.

Uses For

Rolage is used for the prevention and treatment of osteoporosis in postmenopausal women. It is also used to reduce the risk of invasive breast cancer in postmenopausal women who have osteoporosis or who are at high risk for breast cancer.

Mechanism of Action

Rolage works by blocking the effects of the hormone estrogen on certain tissues in the body. This blocking effect is known as selective estrogen receptor modulator (SERM) activity. Rolage binds to estrogen receptors and blocks the hormone’s actions in the uterus, breast, and other tissues.

How Long Does it Take to Work?

Rolage generally takes 6 to 12 months to start working. The bone-building effects may continue for up to 5 years after use is stopped.

Absorption

Rolage is well absorbed and reaches peak concentrations 2 to 4 hours after administration.

Route of Elimination

Rolage is primarily metabolized by the liver, and the metabolites are eliminated from the body largely via the kidney.

Dosage

For the treatment and prevention of postmenopausal osteoporosis, the recommended dose of raloxifene is 60 mg once daily by mouth.

Administration

Rolage is available in a tablet form to be taken orally. The tablets should be taken with a full glass of water and should not be chewed or crushed.

Side Effects

The most common side effects of raloxifene are hot flashes, leg cramps, increased sweating, constipation, and sleep disturbances. Less commonly, raloxifene has been linked to other side effects such as headache, gastrointestinal upset, dizziness, and fatigue

Toxicity

Rolage is generally well tolerated when taken as directed, but serious toxicity has been reported in rare cases. The most common signs of overdose are nausea, vomiting, and abdominal pain.

Precautions

Rolage may interact with other medications, including certain antibiotics, antipsychotics, and anticoagulants and may increase the risk of stroke, blood clots, and heart attack. It is important to talk to your healthcare provider about any other medications and supplements you are taking before using raloxifene.

Interaction

Rolage can interact with some medications, including certain antibiotics, antipsychotics, and anticoagulants. These interactions may increase the risk of stroke, blood clots, and heart attack. It is important to talk to your healthcare provider about any other medications and supplements you are taking before using raloxifene.

Disease Interaction

Rolage may interact with certain diseases, including certain types of cancer, coronary artery disease, and stroke. Tell your healthcare provider if you have any of these conditions before starting raloxifene.

Drug Interaction

Rolage may interact with certain drugs, such as certain antibiotics, antipsychotics, and anticoagulants. These interactions may increase the risk of stroke, blood clots, and heart attack. It is important to talk to your healthcare provider about any other medications and supplements you are taking before using raloxifene.

Food Interactions

Rolage can interact with certain foods, such as grapefruit and grapefruit juice, which may increase the risk of side effects. It is important to talk to your healthcare provider before eating any foods that may interact with raloxifene.

Pregnancy Use

Rolage should not be used during pregnancy, as it may be harmful to the fetus.

Lactation Use

Rolage should not be used while breastfeeding, as it may harm the baby.

Acute Overdose

Signs of an acute overdose of raloxifene may include nausea, vomiting, and abdominal pain. If you suspect an overdose of raloxifene, contact your healthcare provider or nearest emergency room immediately.

Contraindication

Rolage should not be used in people who are allergic to it or to any other ingredients in the medication. Additionally, raloxifene should not be used in women who are pregnant or breastfeeding or in people with a history of blood clots, stroke, or liver disease.

Dose Direction

Rolage is taken orally by mouth once a day, with or without food. The dose for the treatment and prevention of postmenopausal osteoporosis is 60 mg per day.

Storage Condition

Rolage should be stored at room temperature, away from heat and moisture. It should be kept out of the reach of children and pets.

Volume of Distribution

The volume of distribution of raloxifene is approximately 26 liters.

Half Life

The half-life of raloxifene is approximately 29 hours.

Clearance

The clearance of raloxifene is approximately 5.8 ml/min/kg.

Here you find in details version of Rolage

Some Frequently Asked Questions About Rolage

What is Rolage?

Rolage is a prescription medication that is used to treat and prevent osteoporosis in postmenopausal women. It is also used to reduce the risk of invasive breast cancer in certain women who are at high risk for the disease. Rolage works by partially acting like the hormone estrogen in the body.

What does Rolage treat?

Rolage is used to treat and prevent osteoporosis in postmenopausal women and to reduce the risk of invasive breast cancer in certain women who are at high risk for the disease.

What are the side effects of Rolage?

Common side effects of Rolage include hot flashes, leg cramps, joint pain, tiredness, nausea, constipation, gas, stomach pain, and weight changes. Some serious side effects include signs of an allergic reaction, joint problems, vision changes, and swelling of your hands or feet.

How do I take Rolage?

Rolage usually comes in the form of a tablet. It is usually taken once a day with or without food. Make sure you follow the instructions on the label and do not take more or less than your doctor prescribed.

What if I forget to take my Rolage?

If you forget to take your dose of Rolage, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and take your next dose at the regular time.

Are there any drug interactions I should be aware of with Rolage?

Yes, certain medications may interact with Rolage, including certain antibiotics, birth control pills, and anticoagulants. Be sure to tell your doctor about any other medications you are taking before starting Rolage.

Is Rolage safe?

Rolage is generally safe when taken as prescribed. However, it can cause serious side effects in some people, including a serious allergic reaction, blood clots, and worsening of endometriosis. Be sure to talk to your doctor about any possible risks before taking Rolage.

Does Rolage cause weight gain?

It is not known if Rolage causes weight gain. Some people may experience minor weight changes while taking Rolage, but this is not a common side effect of the drug. Talk to your doctor if you have any concerns.

How long does it take for Rolage to work?

Rolage begins to work within a few days of starting the medication. However, it may take several weeks or months to experience the full benefits of the drug.

Does Rolage cause headaches?

Headaches are not a common side effect of Rolage. However, some people may experience mild headaches while taking the drug. If you experience severe or persistent headaches while taking Rolage, talk to your doctor.

Is Rolage safe to take while breastfeeding?

No, it is not recommended to take Rolage while breastfeeding. It is not known if the drug passes into breast milk and could potentially harm a nursing infant. Talk to your doctor about the best options for you.

How long can I take Rolage?

How long you take Rolage depends on your individual needs. Your doctor will decide how long you should take the medication.

Can I drink alcohol while taking Rolage?

It is generally not recommended to drink alcohol while taking Rolage. Alcohol can increase the risk of side effects from this medication, so it is best to avoid alcohol while taking it.

Is Rolage a hormonal medication?

No, Rolage is not a hormone. It works by partially acting like the hormone estrogen in the body.

How does Rolage work?

Rolage works by partially acting like the hormone estrogen in the body. It helps to reduce the risk of osteoporosis and invasive breast cancer in certain women.

Will Rolage help with joint or muscle pain?

Rolage may help to relieve joint and muscle pain caused by osteoporosis. However, it is not approved for this use. Talk to your doctor about other options if you are experiencing joint or muscle pain.

Does Rolage help with hot flashes?

Yes, Rolage may help with hot flashes. It is not approved for this use, but some studies have found that it may help reduce the frequency and severity of hot flashes in some postmenopausal women.

Can Rolage help improve my bone density?

Yes, Rolage can help improve your bone density. Studies have found that it can increase bone density in the spine and hips, and reduce the risk of fractures in postmenopausal women.

What is the recommended dosage of Rolage?

The recommended dosage of Rolage depends on your individual needs. Your doctor will decide the best dosage for you. The usual starting dose of Rolage is 60 mg once a day.

Should I take Rolage with food?

Rolage can be taken with or without food. It is important to take it the same way each day to get the most benefit from the medication.

Can Rolage cause constipation?

Yes, constipation is a common side effect of Rolage. If you become constipated while taking Rolage, be sure to drink plenty of fluids and eat a high-fiber diet.

Should I take any other medications while taking Rolage?

Yes, you may need to take other medications while taking Rolage, such as calcium and vitamin D supplements. Talk to your doctor about the best medications for you.

Can I take Rolage with other osteoporosis medications?

Yes, it is safe to take Rolage with other osteoporosis medications. Be sure to tell your doctor about any other medications you are taking before taking Rolage.

What type of blood tests should I get while taking Rolage?

Your doctor may recommend that you have a complete blood count (CBC) and some liver tests before and during treatment with Rolage. These tests can help to monitor your health while taking the medication.

Are there any other uses for Rolage?

Rolage is approved to treat and prevent osteoporosis and to reduce the risk of invasive breast cancer in certain women at high risk for the disease. It is not approved for any other uses.

Is there a generic version of Rolage?

Yes, there is a generic version of Rolage called Evista. It is the same medication as Rolage but is available at a lower cost.

Should I take Rolage if I'm pregnant or planning to become pregnant?

Rolage is not recommended for use in pregnant women. Talk to your doctor about the best options for you if you are pregnant or planning to become pregnant.

I'm 65 and have post-menopausal osteoporosis. Can I still take Rolage?

Yes, Rolage is approved for use in postmenopausal women. Talk to your doctor about whether Rolage is right for you.

How long should I stay on Rolage?

How long you stay on Rolage depends on your individual needs. Generally, Rolage should be taken for as long as it is helping to prevent fractures and/or reduce the risk of breast cancer. Talk to your doctor about the best course of action for you.

Can I take Rolage with hormonal birth control?

It is not recommended to take Rolage with hormonal birth control. Talk to your doctor about other options for birth control while taking Rolage.

Will Rolage lower my blood pressure?

Rolage may help to lower high blood pressure in some people. However, it is not approved for this use. Talk to your doctor about other medications that may help to lower your blood pressure.

Does Rolage affect cholesterol levels?

Yes, Rolage can affect cholesterol levels. Studies have found that it can help to reduce levels of bad cholesterol (LDL) and increase levels of good cholesterol (HDL). Talk to your doctor about other medications that may help to lower your cholesterol.

Does Rolage help with mood changes?

Rolage may help to reduce tension, irritability, and fatigue in some people. However, it is not approved for this use. Talk to your doctor about other medications that may help with mood changes.

Can I take Rolage with other medications?

Yes, you can take Rolage with other medications. However, certain medications may interact with Rolage, including certain antibiotics, birth control pills and anticoagulants. Be sure to tell your doctor about any other medications you are taking before taking Rolage.

If I take Rolage, will I need to have regular checkups?

Yes, it is recommended that you have regular checkups while taking Rolage. Your doctor may recommend that you have a complete blood count (CBC) and some liver tests before and during treatment with Rolage.

Can I take Rolage if I'm breastfeeding?

No, it is not recommended to take Rolage while breastfeeding. It is not known if the drug passes into breast milk and could potentially harm a nursing infant. Talk to your doctor about the best options for you.

Does Rolage cause any withdrawal symptoms?

No, Rolage does not usually cause any withdrawal symptoms when you stop taking it. However, some people may experience a return of some of the symptoms they were taking Rolage to treat, such as hot flashes or joint pain. Talk to your doctor about any withdrawal symptoms you experience.

If I stop taking Rolage, how soon will I start to feel better?

It may take some time to start feeling better after you stop taking Rolage. Some people may start to feel better within a few days, while others may take longer. Talk to your doctor if you experience any withdrawal symptoms or if your symptoms do not improve.