Roflast
Roflast Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Roflast is a brand name. Its generic name is Roflumilast.
Introduction
Roflast (trade name Daxas) is a phosphodiesterase 4 (PDE4) inhibitor developed by German pharmaceutical company Bayern Innovativ. It is indicated for the treatment of chronic obstructive pulmonary disease (COPD).
Uses
Roflast is used to treat chronic obstructive pulmonary disease (COPD). It works by decreasing inflammation in the lungs, which helps reduce symptoms such as coughing and difficulty breathing.
Mechanism of Action
Roflast works by inhibiting the enzyme phosphodiesterase-4 (PDE4), which is responsible for breaking down a substance called cyclic adenosine monophosphate (cAMP). By blocking this enzyme, Roflast increases levels of cAMP, which helps reduce inflammation in the lungs.
How Long Does It Take To Work?
The effects of Roflast may be seen as early as one week after beginning treatment but the full effects may take 6-8 weeks to be seen.
Absorption
Roflast is rapidly absorbed after oral administration, with peak plasma concentrations reached 1.6-4 hours after dosing. Bioavailability is approximately 60%.
Route of Elimination
Roflast is eliminated primarily by the kidneys, with approximately 85% of an oral dose excreted in the urine.
Dosage
The recommended oral dose of Roflast is one 500 mcg tablet taken once per day. It should be taken with or without meals and can be taken at anytime during the day.
Administration
Roflast is available as a tablet, and should be taken orally with a glass of water.
Side Effects
The most common side effects of Roflast are gastrointestinal effects, including diarrhea, nausea, abdominal pain, and loss of appetite. Other side effects may include headache, depression, insomnia, and weight loss.
Toxicity
The toxic effects of Roflast have not been thoroughly studied. Based on animal studies, high doses of Roflast could cause damage to the liver and kidneys.
Precaution
Inform your healthcare provider if you are pregnant or planning to become pregnant, or if you are breastfeeding or planning to breastfeed. Tell your doctor about all medications you are taking, especially if you are taking other PDE4 inhibitors.
Interaction
Roflast may interact with other drugs, including calcium channel blockers, corticosteroids, tricyclic antidepressants, narcotic pain relievers, and MAO inhibitors. It is recommended that patients taking any of these medications inform their doctor before taking Roflast.
Disease Interaction
Roflast may interact with certain diseases, including cardiovascular disease, diabetes, and kidney and liver disease. It is recommended that patients with any of these conditions inform their doctor before taking Roflast.
Drug Interaction
Certain drugs may interact with Roflast, including antidepressants, steroids, calcium channel blockers, and narcotic pain relievers. It is recommended that patients taking any of these medications inform their doctor before taking Roflast.
Food Interaction
Roflast may interact with certain foods, including grapefruit juice, alcohol, and high-fat meals. It is recommended that these foods be avoided while taking Roflast.
Pregnancy Use
There is limited information available regarding the safety of Roflast during pregnancy. It is recommended that pregnant women should not take Roflast unless the potential benefit justifies the potential risk to the fetus.
Lactation Use
It is not known whether Roflast is excreted in human milk. It is recommended that women who are breastfeeding should not take Roflast unless the potential benefit justifies the potential risks.
Acute Overdose
In the case of an acute overdose, patients should contact a doctor or poison control center immediately. Symptoms of an acute overdose may include nausea, vomiting, abdominal pain, and diarrhea.
Contraindication
Roflast should not be used in patients with known hypersensitivity to the active ingredient or any of the excipients. It should also not be used in patients with severe liver or kidney impairment or in patients taking ketoconazole.
Use Direction
Roflast should be taken once daily with or without food. It is recommended that it should not be taken in combination with other PDE4 inhibitors.
Storage Condition
Roflast tablets should be stored at a temperature between 15°C and 25°C and should be kept away from light and moisture.
Volume of Distribution
Roflast has a volume of distribution of 0.91 L/kg.
Half Life
The half-life of Roflast is approximately 11 hours.
Clearance
Roflast has an oral clearance of approximately 7.3 L/h.
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