Rizatin

Rizatin Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Rizatin is a brand name. Its generic name is Rizatriptan.

Rizatin: Introduction

Rizatin (Maxalt, Maxalt-MLT) is a serotonin 5-HT1B/1D receptor agonist and antimigraine drug. It is used to treat acute migraine attacks, with or without aura (temporary visual disturbances or other symptoms), in adults. Rizatin relieves migraine pain and associated symptoms such as nausea and sensitivity to sound and light.

Uses For

Rizatin is used to treat the symptoms of migraine headaches (severe, throbbing headaches that sometimes are accompanied by nausea and sensitivity to sound and light). Rizatin will not prevent the occurrence of migraine headaches.

Mechanism of Action

Rizatin is a serotonin 5-HT1B/1D receptor agonist with antimigraine activity. It binds selectively and with high affinity to 5-HT1B and 5-HT1D receptors, resulting in serotonin-mediated constriction of arteriolar blood vessels in the brain, relief from pain, and a decrease in inflammation. It is also thought to inhibit release of neuropeptides such as CGRP (calcitonin gene-related peptide), which is associated with migraine.

How Long Does it Take to Work?

Rizatin usually begins to work within 30 minutes of taking the tablet, and reaches its peak effect within two hours.

Absorption

Rizatin is rapidly and well-absorbed from the gastrointestinal tract. The absolute bioavailability is 25%, because of presystemic metabolism. Peak plasma concentrations occur 1-2 hours after oral administration. The bioavailability of Maxalt-MLT (a lyophilized orally disintegrating tablet) is comparable to that of Maxalt.

Route of Elimination

Rizatin is eliminted primarily by hepatic metabolism and biliary excretion of metabolites. The drug has a plasma terminal elimination half-life of about 2 to 3 hours.

Dosage

The usual recommended adult dose of rizatriptan is 5 to 10 mg. Dose can be increased to a maximum of 30 mg in a 24-hour period.

Administration

Rizatin tablets should be taken whole. They should not be chewed, split, or dissolved. Maxalt-MLT orally disintegrating tablets should be placed on the tongue and allowed to dissolve without being chewed or swallowed.

Side Effects

The most common side effects of rizatriptan include dizziness, headache, fatigue, dry mouth, and nausea. Less common side effects include chest pain, flushing or warmth, hot flashes, muscle tightness or pain, sleepiness, tingling sensations, throat irritation, tightness or heaviness.

Toxicity

Overdoses of rizatriptan can produce symptoms of serotonin syndrome, including agitation, confusion, fast heartbeat, sweating, tremor, diarrhea, or vomiting.

Precautions

Before using rizatriptan, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. Rizatin should not be used if you have certain medical conditions, such as ischemic heart disease, coronary artery vasospasm, history of stroke or TIA, or hemiplegic or basilar migraine.

Interactions

Rizatin may interact with other medications such as MAO inhibitors, propranolol, dihydroergotamine, or St. John's wort. Tell your doctor all medications you are currently taking, including those over-the-counter.

Disease Interactions

Rizatin is not recommended in patients with ischemic heart disease, coronary artery vasospasm, history of stroke or TIA, or hemiplegic or basilar migraine.

Drug Interactions

Rizatin may interact with MAO inhibitors, propranolol, dihydroergotamine, or St. John's wort. Tell your doctor all medications you are currently taking, including those over-the-counter.

Food Interactions

Rizatin should be taken at least two hours after or one hour before a meal. Taking Rizatin with food may increase the rate of absorption, resulting in increased systemic exposure and increased the risk of side effects.

Pregnancy Use

Rizatin should not be used in pregnant women unless the potential benefit outweighs the potential risk to the fetus.

Lactation Use

It is not recommended to use rizatriptan during breastfeeding. Consult your doctor before taking this medication during lactation.

Acute Overdose

Symptoms of an acute overdose of rizatriptan may include nausea, vomiting, confusion, dizziness, double vision, dizziness, sweating, tremor, diarrhea, or vomiting.

Contraindication

Rizatin is contraindicated in patients with ischemic heart disease, coronary artery vasospasm, history of stroke or TIA, or hemiplegic or basilar migraine.

Use Directions

To take rizatriptan, you should take one 5 to 10 mg tablet with water as soon as you experience migraine symptoms. Do not take more than 30 mg in 24 hours. If the headache returns after a period of relief, you can take second dose 2 hours later (maximum 30 mg per day). Do not take rizatriptan more than twice every 24 hours. If the symptoms do not improve, contact your doctor.

Storage Conditions

Rizatin should be stored at room temperature, away from heat, moisture, and light. Keep out of reach of children.

Volume of Distribution

The average apparent volume of distribution of rizatriptan is about 165 liters.

Half Life

The elimination half-life of rizatriptan is approximately 2-3 hours.

Clearance

The apparent clearance of rizatriptan after intravenous administration is approximately 10 liters/hour.

Here you find in details version of Rizatin

Some Frequently Asked Questions About Rizatin

What is Rizatin?

Rizatin is a medication used to treat migraine headaches. It is a prescription medication available in tablet and orally disintegrating tablet form.

What is the generic name for Rizatin?

The generic name for Rizatin is rizatriptan benzoate.

How does Rizatin work?

Rizatin works by narrowing the blood vessels around the brain and relieving the symptoms of a migraine headache. It also helps to reduce substances in the body that can cause headache, nausea, sensitivity to light and sound, and other migraine symptoms.

How long does it take for Rizatin to work?

Rizatin usually begins to work within 30 minutes after taking the tablet. However, it can take up to two hours for the full effects of the medication to be felt.

How much does Rizatin cost?

The cost of Rizatin will depend on the dosage and quantity prescribed. It is recommended that you speak with your healthcare provider to determine the cost of your prescription.

What are the potential side effects of Rizatin?

The most common side effects of Rizatin include drowsiness, dizziness, tingling or numbness in extremities, fatigue, muscle or body aches, and nausea. Other more serious side effects include an irregular heartbeat, chest pain, and difficulty breathing. If you experience any of these side effects, contact your healthcare provider immediately.

Can I take Rizatin while pregnant?

It is not recommended that Rizatin be taken while pregnant as its safety has not been established in pregnant women. Speak with your healthcare provider about the best treatment for your migraines while pregnant.

Can I take Rizatin while breastfeeding?

It is not recommended that Rizatin be taken while breastfeeding as its safety has not been established in breastfeeding women. Speak with your healthcare provider about the best treatment for your migraines while breastfeeding.

Is Rizatin covered by my insurance?

The coverage of Rizatin by your insurance policy will depend on your individual coverage. It is recommended that you contact your insurance provider to determine if your prescription will be covered.

Can I take Rizatin with other medications?

It is generally recommended that you do not take Rizatin with other medications without speaking to your healthcare provider first. This is especially true if you are taking medications that affect serotonin levels in the body, such as antidepressants.

Does Rizatin interact with any foods or alcohol?

Rizatin may interact with certain foods or beverages, such as alcohol, caffeinated drinks, and certain types of cheese. It is generally recommended that you avoid consuming these foods or drinks while taking Rizatin.

What should I do if I miss a dose of Rizatin?

If you miss a dose of Rizatin, take it as soon as you remember. Do not take a double dose to make up for the missed dose. Contact your healthcare provider if you think you need a different dosing schedule.

Can I take Rizatin daily?

Rizatin is not intended to be taken on a daily basis. If you are having daily migraine headaches, contact your healthcare provider to discuss other treatment options.

Does Rizatin expire?

Yes, Rizatin tablets and orally disintegrating tablets do have an expiration date. Always check the expiration date on the package and do not use the medication if it is expired.

Can I take Rizatin with acetaminophen?

It is generally not recommended that you take Rizatin with acetaminophen. Speak with your healthcare provider to determine if it is safe for you to take both medications together.

Can I take Rizatin if I have kidney disease?

If you have kidney disease, it is recommended that you speak with your healthcare provider before taking Rizatin. Your healthcare provider may adjust the dosage or frequency of the medication depending on the severity of your kidney disease.

What should I do if I overdose on Rizatin?

If you think you may have overdosed on Rizatin, it is important to seek medical attention immediately. Signs of an overdose may include seizures, loss of consciousness, difficulty breathing, chest pain, irregular heartbeat, or confusion.

Can I take Rizatin while taking other migraine treatments?

It is generally recommended that Rizatin should not be taken with other migraine treatments such as triptans, opioids, or other ergots. If you need to take other medications for your migraines, speak to your healthcare provider to ensure it is safe to do so.

Is Rizatin habit forming?

No, Rizatin is not habit forming. However, if you do need to take the medication often, speak with your healthcare provider to ensure it is appropriate for your condition.

Can Rizatin be cut or split?

Rizatin tablets should not be split, chewed, or crushed. If you have difficulty swallowing the tablets, you may take the orally disintegrating tablets, which dissolve on the tongue.

Who should not take Rizatin?

Rizatin should not be taken if you are allergic to it or have experienced a reaction to taking triptans. It should also not be taken if you are currently taking monoamine oxidase inhibitors or if you have heart disease, stroke, or circulation problems.

Can Rizatin be used to treat cluster headaches?

No, Rizatin is not proven to be effective in treating cluster headaches. Speak to your healthcare provider about other treatment options for cluster headaches.

How should Rizatin be stored?

Rizatin should be stored at room temperature, away from direct light and moisture. Do not store it in the bathroom or near any heat sources. Make sure to keep it out of the reach of children and pets.

Can I take Rizatin if I have high blood pressure?

If you have high blood pressure, it is recommended that you speak to your healthcare provider before taking Rizatin. Your healthcare provider may determine that taking Rizatin is appropriate for you.

Can I take Rizatin if I am taking birth control?

Yes, it is generally safe to take Rizatin if you are taking birth control medication. However, it is recommended that you speak to your healthcare provider just to make sure.

Can I take Rizatin if I have a history of stroke?

No, you should not take Rizatin if you have had a stroke or if you have circulation problems. Speak with your healthcare provider about other treatment options.

Can Rizatin be used to prevent migraines?

No, Rizatin is not indicated for the prevention of migraines. Speak with your healthcare provider to discuss other preventive treatment options.

Can I take Rizatin if I am over 65?

Yes, it is generally safe for those over 65 to take Rizatin. However, it is always recommended that you speak to your healthcare provider before taking any medication.

Does Rizatin have any drug interactions?

Yes, there are several medications that can interact with Rizatin. These include serotonin antagonists, monoamine oxidase inhibitors, medications that affect serotonin levels in the body, and isocarboxazid. It is important to speak with your healthcare provider or pharmacist to make sure it is safe to take Rizatin while taking other medications.

What should I know before taking Rizatin?

Before taking Rizatin, it is important to discuss your medical history with your healthcare provider. Make sure to let them know about any other medications you are taking, any allergies you have, and any other medical or mental health conditions you have.

Is Rizatin available in generic form?

Yes, Rizatin is available in generic form. It is important to let your healthcare provider know that you would prefer the generic version of the medication and make sure to confirm the dosage and quantity before leaving the pharmacy.

What should I do if I experience side effects from Rizatin?

If you experience side effects from Rizatin, speak to your healthcare provider immediately. They may be able to adjust the dosage or frequency of the medication, or offer alternative treatment options.

Can I take Rizatin while taking warfarin?

Yes, it is generally safe to take Rizatin while taking warfarin. However, it is important to speak to your healthcare provider or pharmacist to make sure that it is safe to do so.

Does Rizatin cause weight gain?

Weight gain is not a known side effect of Rizatin. However, if you do experience sudden and unexplained weight gain while taking Rizatin, contact your healthcare provider.

What is the recommended dosage of Rizatin?

The recommended dosage of Rizatin for adults is 5 or 10 mg, taken as soon as the headache symptoms begin. Do not exceed the recommended dosage and do not take more than 30 mg in a 24 hour period.

Does Rizatin have any effect on fertility?

There is currently no evidence that Rizatin affects fertility in either men or women. However, if you are nursing, pregnant, or planning to become pregnant, speak to your healthcare provider about the potential risks of taking Rizatin.

Is Rizatin approved by the FDA?

Yes, Rizatin is approved for use by the US Food and Drug Administration (FDA).

Does Rizatin cause constipation?

Constipation is not a common side effect of Rizatin. However, if you experience constipation while taking Rizatin, contact your healthcare provider.

Can I take Rizatin if I have liver disease?

If you have liver disease, it is recommended that you speak to your healthcare provider before taking Rizatin. Your healthcare provider may adjust the dosage or frequency of the medication depending on the severity of your liver disease.

Does Rizatin cause drowsiness?

Yes, drowsiness is a common side effect of Rizatin. It is important to be aware of this side effect before taking the medication and before performing any tasks that might require alertness, such as driving or operating heavy machinery.