Rhophylac 300
Rhophylac 300 Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Rhophylac 300 is a brand name. Its generic name is Human Anti-D Immunoglobulins.
Anti-D Immunoglobulins
Anti-D Immunoglobulins is a type of antibody that occurs naturally in humans, and is also made artificially under laboratory conditions. The production of the immunoglobulin is the main purpose of an Immunoglobulin Intravascular (IVIG) treatment. Anti-D Immunoglobulins is used to prevent Rh isoimmunization (Rh and D antigen incompatibility) and to treat severe hemolytic diseases (HDN) resulting from such incompatibilities between mother and fetus.
Uses For
Anti-D Immunoglobulins is used to prevent Rh isoimmunization and to treat severe hemolytic diseases resulting from such incompatibilities between mother and fetus. It is also used to treat Rh-sensitization in pregnancy or postpartum in Rh negative women.
Mechanism of Action
- The intravenous injection of Anti-D Immunoglobulins binds to theRh+ red blood cells in the fetal circulation, resulting in their lysis and thus preventing Rh isoimmunization. This prevents the mother from producing harmful antibodies against any future pregnancies.
- The Anti-D Immunoglobulins also binds to Rh+ red blood cells in the mother's circulation, helping to protect the fetus from the harmful antibodies produced by the mother.
How Long Does It Take To Work?
The effects of Anti-D Immunoglobulins can be seen within 1-2 weeks after the intravenous injection.
Absorption
The Anti-D Immunoglobulins can be rapidly absorbed from the blood stream into the tissue.
Route of Elimination
The Anti-D Immunoglobulins is cleared from the body by the liver and kidneys. It can also be removed from the body via urine and feces.
Dosage
The Anti-D Immunoglobulins dose depends on the patient’s condition and other factors. The recommended dosage is 200 IU/kg and can range between 50-400 IU/kg.
Administration
The Anti-D Immunoglobulins should be given intravenously at a slow rate over several hours, usually once per month.
Side Effects
Common side effects of Anti-D Immunoglobulins include fatigue, headache, fever, injection site reactions, hives, difficulty breathing, and chest pain.
Toxicity
Excessive or prolonged treatment with Anti-D Immunoglobulins can lead to serious side effects and anaphylaxis. It is also toxic to platelets and red blood cells.
Precaution
Before receiving an Anti-D Immunoglobulins treatment, it is important to let your doctor know about any allergies you may have, as well as any other medications or supplements you may be taking.
Interaction
Anti-D Immunoglobulins may interact with certain medications and supplements. Therefore, it is important to let your doctor know about all medications you currently take.
Disease Interaction
Patients with certain pre-existing conditions, such as liver or kidney disease, may be at an increased risk of experiencing adverse reactions due to the Anti-D Immunoglobulins.
Drug Interaction
Anti-D Immunoglobulins may interact with certain drugs, including anticoagulants, antibiotics, antivirals, antifungals, and immunosuppressants. It is important to let your doctor know if you are taking any medications that may interact with the medication.
Food Interactions
There are no known food interactions associated with Anti-D Immunoglobulins.
Pregnancy Use
Anti-D Immunoglobulins is generally considered safe for use in pregnant women. However, it should be used with caution in women with pre-existing medical conditions or allergies to certain medications.
Lactation Use
Anti-D Immunoglobulins is safe for use in breastfeeding women. However, it may pass through breast milk and could theoretically affect the breast-feeding baby.
Acute Overdose
An acute overdose of Anti-D Immunoglobulins is unlikely and symptoms of an overdose may include nausea, vomiting, and fever.
Contraindication
Anti-D Immunoglobulins should not be used in patients with an allergy to any of its components, and should be used with caution in patients with pre-existing medical conditions.
Use Direction
Anti-D Immunoglobulins should be given according to the prescribing doctor’s instructions. It should be administered slowly over several hours intravenously.
Storage Condition
Anti-D Immunoglobulins should be stored at room temperature between 59-86°F (15-30°C). It should be kept in its original container and protected from light and heat.
Volume of Distribution
The volume of distribution for the Anti-D Immunoglobulins is 1.74 liters/kg.
Half Life
The half life for the Anti-D Immunoglobulins is approximately 5 days.
Clearance
The clearance rate for Anti-D Immunoglobulins is 0.17 liters/kg/day.
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