Ranitidina

Ranitidina, a brand name for a formulation containing essential Ranitidine, is widely used for various health benefits. This guide provides comprehensive information on the uses, dosage, side effects, and mechanism of action of Ranitidina, as well as insights into how long it takes to work. Understanding these aspects can help you make informed decisions about its use and effectiveness.

Introduction

Ranitidina is a histamine-2(H2)-blocker used to treat and prevent stomach and duodenal ulcers, and to treat other stomach and gastrointestinal conditions. It is an over-the-counter drug, available both as a prescription and non-prescription medication.

Uses

Ranitidina is used to treat gastrointestinal disorders such as gastroesophageal reflux disease (GERD), ulcers, and other conditions involving excessive stomach acid. It can also be used to prevent stress ulcers, to treat heartburn, and to reduce the occurrence of stomach or duodenal ulcers

Mechanism of Action

Ranitidina works by reducing the amount of acid produced by the stomach, therefore reducing the symptoms of heartburn and other gastrointestinal conditions. It does this by blocking histamine-2, which reduces the amount of acid production in the stomach in response to food.

How Long Does it Take to Work?

Ranitidina begins to reduce stomach acid production and improve symptoms within a few hours or days after the first dose. The maximum benefit is usually reached within 4 weeks.

Absorption

Ranitidina is well absorbed in the stomach and intestine. It has an oral absorption rate of 65-80%.

Route of Elimination

Ranitidina is eliminated by the kidneys through urine via glomerular filtration and tubular secretion. Its elimination half-life is 1-2 hours.

Dosage

Ranitidina is available in tablets, capsules, and suspension forms. The dosage forms and strengths are as follows:

  • Tablet: 75 mg, 150 mg, and 300 mg
  • Capsules: 75 mg and 150 mg
  • Suspension: 10 mg/mL

The usual adult dose for treatment of active duodenal ulcers is 150 mg to 300 mg twice daily. For maintenance of healing of duodenal ulcers, 150 mg once daily is recommended.

For treatment of esophageal reflux, the usual dose is 150 to 300 mg twice daily. For maintenance of healing of esophageal lesions, the recommended dose is 150 mg once daily.

For treatment of conditions involving excessive stomach acid, the recommended dose is 150 to 300 mg twice daily.

Administration

Ranitidina can be taken with or without food. It should be taken with a full glass of water to ensure that it is completely absorbed. It is important to consume the full amount of water that is recommended for each dose.

Side Effects

Common side effects of ranitidine include headache, diarrhea, constipation, nausea, rash, dizziness, and abdominal pain. Less common side effects may include muscle pain, joint pain, fever, mental confusion, and depression.

Toxicity

Ranitidina has a low toxicity and is generally well tolerated. Large doses may cause hypotension and can be fatal in cases of overdose.

Precautions

Ranitidina should be used with caution in people with kidney or liver disease, and those with a history of drug allergies.

Interactions

Ranitidina may interact with other medications including antacids, drugs used to treat heartburn, anti-seizure medications, certain antibiotics, and theophyllines.

Disease Interactions

Ranitidina should not be used in people with porphyria, a rare metabolic disorder. It should also be used with caution in people with severe kidney disease.

Drug Interactions

Ranitidina can interact with certain medications such as antacids, drugs used to treat heartburn, anti-seizure medications, certain antibiotics, and theophyllines. Be sure to discuss all medications you are taking with your healthcare provider before taking ranitidine.

Food Interactions

Ranitidina may interact with food. Consuming alcohol while taking ranitidine may increase the risk of side effects such as headache, dizziness, and drowsiness.

Pregnancy Use

Ranitidina should only be used during pregnancy if the potential benefit justifies the potential risk to the fetus. Be sure to discuss the use of ranitidine with your healthcare provider before using it during pregnancy.

Lactation Use

Ranitidina is excreted in breast milk and may affect a nursing baby. Therefore, it should be used with caution in breastfeeding women.

Acute Overdose

If an overdose of Ranitidina occurs, seek medical attention immediately. Symptoms of overdose may include low blood pressure, dizziness, and unusual sleepiness.

Contraindication

Ranitidina is contraindicated in people who are allergic to the active ingredient in the drug.

Use Direction

Ranitidina should be taken as directed by your healthcare provider. The usual adult dose for treatment of active duodenal ulcers is 150 mg to 300 mg twice daily. For maintenance of healing of duodenal ulcers, 150 mg once daily is recommended.

Storage Condition

Ranitidina should be stored at room temperature, away from heat and moisture. Keep out of reach of children.

Volume of Distribution

The apparent volume of distribution for Ranitidina is 5L/kg.

Half Life

The half-life of Ranitidina is 1-2 hours.

Clearance

The clearance for Ranitidina is 10 mL/min/kg.

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