Purilin

Purilin Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Purilin is a brand name. Its generic name is Levosalbutamol.

Introduction

Purilin is a β-agonist bronchodilator used in the treatment of asthma and chronic obstructive pulmonary disease (COPD). It is a long-acting β-adrenergic agonist (LABA) that is an active isomer of albuterol, which belongs to a family of drugs called sympathomimetics. Purilin helps to relax the muscles in the airways, which helps widen the airways resulting in decreased airway obstruction.

Uses

Purilin is used in the long-term management of asthma and COPD to improve air flow to the lungs. It is also used to prevent exercise-induced bronchospasm (EIB) in people with asthma, and to treat wheezing, shortness of breath, and other symptoms of airway obstruction in people with COPD.

Mechanism of action

Purilin works by stimulating β-adrenergic receptors on airway smooth muscle. This causes relaxation of the airways and improved airflow.

How long does it take to work?

Purilin begins to work within minutes of inhalation, with peak therapeutic effect at approximately 30 minutes.

Absorption

The absorption of levalbutamol is rapid and the drug is completely absorbed within 10 minutes after inhalation.

Route of elimination

Purilin is eliminated primarily through metabolic processes in the liver.

Dosage

The recommended dose of levalbutamol is 200 mcg twice daily for adults and adolescents with asthma, and 500 mcg twice daily for adults and adolescents with COPD.

Administration

Purilin is available as an inhaler, and should be inhaled directly into the mouth, or with a spacer device.

Side effects

The most common side effects of levalbutamol are headache, throat irritation, nausea, and dizziness.

Toxicity

Acute overdose of levalbutamol can result in restlessness, palpitations, and increased blood pressure, heart rate, and respiratory rate.

Precaution

Purilin should not be used in people with hypersensitivity to sympathomimetic amines, medical conditions such as severe cardiac arrhythmia, tachycardia, or hypertension, or people with hyperthyroidism or diabetes.

Interaction

Purilin may interact with other medications. Tell your doctor all medications and supplements you are taking before using levalbutamol.

Disease Interaction

Purilin may interact with certain conditions or diseases. Tell your doctor about any medical conditions you have before using levalbutamol.

Drug Interactions

Purilin may interact with other medications. Tell your doctor all medications and supplements you are taking before using levalbutamol.

Food Interactions

Purilin does not typically interact with foods. However, people with diabetes should monitor their blood sugar levels more closely while taking levalbutamol.

Pregnancy Use

Purilin should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus.

Lactation Use

Purilin is excreted in human milk and should be used with caution in lactating women.

Acute Overdose

Symptoms of acute overdose of levalbutamol include restlessness, palpitations, increased blood pressure, heart rate, and respiratory rate. Treatment should be supportive and symptomatic.

Contraindication

Use Directions

Follow the directions for using levalbutamol exactly. Do not use it more often or use more of it than prescribed. Do not stop taking levalbutamol without talking to your doctor first.

Storage Conditions

Store levalbutamol at room temperature, away from direct sunlight, moisture and heat.

Volume of Distribution

The volume of distribution of levalbutamol is 3.2 L/kg.

Half Life

The half-life of levalbutamol is approximately 3-4 hours.

Clearance

The clearance of levalbutamol is approximately 4 mL/min/kg.

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