Puri Nethol

Puri Nethol Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Puri Nethol is a brand name. Its generic name is Mercaptopurine.

Introduction

Puri Nethol (also known by its brand name, Purinethol) is a drug used in the treatment of acute lymphoblastic leukemia. It is used in combination with other drugs to reduce the number of leukemic cells and prevent relapses. Puri Nethol can also be used for a variety of other conditions, such as Crohn’s disease and ulcerative colitis.

Uses and Mechanism of Action

Puri Nethol is a purine analog, a type of chemotherapy drug that works by blocking the activity of enzymes involved in the replication and growth of cancer cells. By inhibiting the action of these enzymes, mercaptopurine helps to stop the spread of cancer cells and prevent relapses. Puri Nethol can also be used to reduce inflammation in acute and chronic inflammatory diseases such as Crohn’s disease and ulcerative colitis.

How Long Does it Take to Work?

The effects of mercaptopurine can vary depending on the condition being treated, but most drugs that contain mercaptopurine begin to take effect within a few weeks of starting the medication.

Absorption, Route of Elimination, Dosage, Administration, and Side Effects

Puri Nethol is administered orally or by injection and is absorbed through the digestive tract. It is then eliminated mainly through the kidneys. The usual dose of mercaptopurine is 2.5–7.5 mg/kg body weight per day, taken in divided doses two or three times per day. It is important to take mercaptopurine exactly as your doctor prescribes and not to miss any doses. Side effects of mercaptopurine include gastrointestinal distress, such as nausea, vomiting, and diarrhea, fatigue, hair loss, and an increased risk of infection.

Toxicity, Precaution, Interactions, Disease Interactions, Drug Interactions, Food Interactions, Pregnancy Use, and Lactation Use

Puri Nethol has a high toxicity and can cause serious damage to the bone marrow and liver. It is important to talk to your doctor about any conditions or medications that may interact with mercaptopurine before taking it. For example, there are some drugs that can increase the risk of mercaptopurine toxicity, such as antacids and other medications that contain aluminum. Women should let their doctor know if they are pregnant or breastfeeding before taking mercaptopurine.

Acute Overdose, Contraindication, Use Direction, Storage Condition, Volume of Distribution, Half Life, and Clearance

An acute overdose of mercaptopurine can be dangerous and should be treated immediately. Puri Nethol is contraindicated in patients with severe liver or kidney disease, and in patients taking certain medications. It should be stored in tight containers, away from heat and moisture. The volume of distribution of mercaptopurine is small, with a median half-life of 80 minutes and a clearance of 11-15L/hr.

Here you find in details version of Puri Nethol

Some Frequently Asked Questions About Puri Nethol

What is mercaptopurine?

Puri Nethol (also known as 6-mercaptopurine) is an immunosuppressant and antitumor agent used to treat certain types of cancer. It is a type of purine analog and works by interfering with the DNA and RNA of tumor cells, preventing them from growing and multiplying.

How does Puri Nethol work?

Puri Nethol works by interfering with the growth and division of cancer cells. It targets the DNA and RNA of tumor cells, stopping them from replicating and growing. It is also known to interfere with enzymes called thiopurine methyltransferase (TPMT) which are thought to be involved in the breakdown of certain purine drugs.

What is Puri Nethol used for?

Puri Nethol is used to treat certain types of leukemia, such as acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). It can also be used as an immunosuppressant to suppress the immune system in people with Crohn's disease, rheumatoid arthritis, and psoriasis.

What are the side effects of Puri Nethol?

Common side effects of Puri Nethol include nausea, vomiting, loss of appetite, mouth sores, diarrhea, fever, rash, and hair loss. More serious side effects can include increased risk of infection, allergic reactions, liver damage, and anemia.

Is Puri Nethol safe?

Puri Nethol is generally safe when taken as prescribed and monitored closely for side effects. It is important to notify a doctor immediately if any new or worsening symptoms occur while taking Puri Nethol.

Can Puri Nethol affect the liver?

Yes, Puri Nethol can affect the liver. It can cause symptoms such as jaundice (yellowing of the skin and eyes), dark urine, and abdominal pain. If these symptoms occur, it is important to notify a doctor immediately.

What is the dosage for Puri Nethol?

The dosage of mercaptopurine depends on the individual and the condition being treated. It is important to follow your doctor’s instructions when taking this medication.

Does Puri Nethol interact with other medications?

Yes, Puri Nethol can interact with other medications. It is important to tell your doctor about all the medications that you are taking. Some of the drugs that can interact with mercaptopurine include allopurinol, cholestyramine, and certain antibiotics.

Does Puri Nethol need to be refrigerated?

No, Puri Nethol does not need to be refrigerated. However, it should be stored at room temperature away from light and moisture.

Can Puri Nethol cause cancer?

No, Puri Nethol is used to treat certain types of cancer, not cause it. However, long-term use of Puri Nethol has been linked to an increased risk of some types of cancer.

Can I drink alcohol while taking Puri Nethol?

No, it is not recommended to drink alcohol while taking Puri Nethol. Alcohol can increase the risk of side effects such as nausea, vomiting, and liver damage.

What should I do if I miss a dose of Puri Nethol?

If you miss a dose of mercaptopurine, it is important to take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for the missed dose.

Can pregnant women take Puri Nethol?

No, it is not recommended for pregnant women to take mercaptopurine. This medication can be passed to a fetus via the placenta and can cause birth defects. Women who are pregnant or planning to become pregnant should talk to their doctor before taking this medication.

Is Puri Nethol covered by insurance?

Depends. It depends on your health insurance provider and coverage that you have. It is best to check with your insurance provider to see if Puri Nethol is included in your plan.

Does Puri Nethol need to be taken with food?

No, Puri Nethol does not need to be taken with food. However, it is best to take it at the same time each day and to avoid taking it on an empty stomach.

What is the typical length of treatment with Puri Nethol?

The length of treatment with Puri Nethol depends on the individual and the condition being treated. It is best to follow the instructions of your doctor when taking this medication.

What type of cancer does Puri Nethol treat?

Does Puri Nethol cause infertility?

No, Puri Nethol does not cause infertility. However, it can cause certain side effects that may affect fertility, such as hair loss and anemia.

Can Puri Nethol be taken long-term?

Yes, Puri Nethol can be taken long-term depending on the condition being treated and the individual. It is important to follow the instructions of your doctor when taking this medication.

How long does it take for Puri Nethol to start working?

The timeframe for Puri Nethol to start working depends on the condition being treated and the individual. It is important to follow the instructions of your doctor when taking this medication.

What should be done if an overdose of Puri Nethol is taken?

If an overdose of Puri Nethol is taken, it is important to seek medical help immediately. Symptoms of an overdose can include nausea, vomiting, loss of appetite, mouth sores, diarrhea, fever, rash, and hair loss.

How often should Puri Nethol be taken?

The frequency of taking Puri Nethol depends on the individual and the condition being treated. It is important to follow the instructions of your doctor when taking this medication.

Can mercaptopurine cause joint pain?

Yes, Puri Nethol can cause joint pain. If joint pain occurs, it is important to notify a doctor immediately.

Can Puri Nethol cause stomach pain?

Yes, Puri Nethol can cause stomach pain. If stomach pain occurs, it is important to notify a doctor immediately.

Can Puri Nethol cause dizziness?

Yes, Puri Nethol can cause dizziness. If dizziness occurs, it is important to notify a doctor immediately.

Can Puri Nethol cause headaches?

Yes, Puri Nethol can cause headaches. If headaches occur, it is important to notify a doctor immediately.

Can Puri Nethol cause blurred vision?

Yes, Puri Nethol can cause blurred vision. If blurred vision occurs, it is important to notify a doctor immediately.

Can Puri Nethol cause anemia?

Yes, Puri Nethol can cause anemia. If anemia occurs, it is important to notify a doctor immediately.

Can Puri Nethol cause hair loss?

Yes, Puri Nethol can cause hair loss. If hair loss occurs, it is important to notify a doctor immediately.

Can Puri Nethol cause mouth sores?

Yes, Puri Nethol can cause mouth sores. If mouth sores occur, it is important to notify a doctor immediately.

Can Puri Nethol cause diarrhea?

Yes, Puri Nethol can cause diarrhea. If diarrhea occurs, it is important to notify a doctor immediately.

Can Puri Nethol cause liver damage?

Yes, Puri Nethol can cause liver damage. If liver damage occurs, it is important to notify a doctor immediately.

Can Puri Nethol cause weight gain?

Yes, Puri Nethol can cause weight gain. If weight gain occurs, it is important to notify a doctor immediately.

Can Puri Nethol cause kidney damage?

Yes, Puri Nethol can cause kidney damage. If kidney damage occurs, it is important to notify a doctor immediately.

Can Puri Nethol cause breathing problems?

Yes, Puri Nethol can cause breathing problems. If breathing problems occur, it is important to notify a doctor immediately.

Can Puri Nethol cause a rash?

Yes, Puri Nethol can cause a rash. If a rash occurs, it is important to notify a doctor immediately.

Can Puri Nethol cause fever?

Yes, Puri Nethol can cause fever. If fever occurs, it is important to notify a doctor immediately.

Can Puri Nethol cause joint swelling?

Yes, Puri Nethol can cause joint swelling. If joint swelling occurs, it is important to notify a doctor immediately.

Can Puri Nethol cause muscle pain?

Yes, Puri Nethol can cause muscle pain. If muscle pain occurs, it is important to notify a doctor immediately.

Can Puri Nethol cause mood changes?

Yes, Puri Nethol can cause mood changes. If mood changes occur, it is important to notify a doctor immediately.

Can Puri Nethol cause neurological problems?

Yes, Puri Nethol can cause neurological problems. If neurological problems occur, it is important to notify a doctor immediately.

Can Puri Nethol cause heart problems?

Yes, Puri Nethol can cause heart problems. If heart problems occur, it is important to notify a doctor immediately.

Can Puri Nethol cause blood pressure changes?

Yes, Puri Nethol can cause blood pressure changes. If blood pressure changes occur, it is important to notify a doctor immediately.