প্রোকাইন্ড এ আছে Propantheline Bromide। প্রোকাইন্ড এর কাজঃ

Propantheline is used with other medications to treat peptic ulcers. It works by decreasing the release of acid in the stomach.

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ব্র্যান্ড নাম প্রোকাইন্ড
জেনেরিকঃ Propantheline Bromide
পরিমাপঃ 15 mg
ধরণঃ ট্যাবলেট
চিকিৎসাগত শ্রেণিঃ Anticholinergics (antimuscarinics)/ Anti-spasmodics
উৎপাদনকারীঃ Beacon Pharmaceuticals Ltd
দামঃ 11.20
সর্বশেষ সম্পাদনাঃ 2020-11-21 18:15:00
পরিচিতি

Propantheline bromide inhibits gastrointestinal motility and diminishes gastric acid secretion. The drug also inhibits the action of acetylcholine at the postganglionic nerve endings of the parasympathetic nervous system.

Propantheline bromide is extensively metabolized in man primarily by hydrolysis to the inactive materials xanthene-9-carboxylic acid and (2-hydroxyethyl) diisopropylmethylammonium bromide. In a bioavailability study, peak plasma concentrations of propantheline were achieved in about one hour, following a single oral dose.

The plasma elimination half-life of propantheline is about 1.6 hours. Approximately 70% of the dose is excreted in the urine, mostly as metabolites. The urinary excretion of propantheline is about 3% after oral tablet administration.

খাওয়ার নিয়ম

প্রোকাইন্ড এ আছে Propantheline Bromide 15 mg। প্রোকাইন্ড খাওয়ার নিয়ম নিম্নরূপঃ

Adult dose: The usual initial adult dose of propantheline bromide tablets is 15 mg taken 30 minutes before each meal and 30 mg at bedtime (a total of 75 mg daily). Subsequent dosage adjustment should be made according to the patient’s individual response and tolerance.

Pediatric Use: Safety and effectiveness in children have not been established.

 

পার্শ্বপ্রতিক্রিয়া

Varying degrees of drying of salivary secretions may occur as well as decreased sweating. Ophthalmic side effects include blurred vision, mydriasis, cycloplegia, and increased ocular tension. Other reported adverse reactions include urinary hesitancy and retention, tachycardia, palpitations, loss of the sense of taste, headache, nervousness, mental confusion, drowsiness, weakness, dizziness, insomnia, nausea, vomiting, constipation, bloated feeling, impotence, suppression of lactation, and allergic reactions or drug idiosyncracies including anaphylaxis, urticaria and other dermal manifestations.

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সতর্কতা

Propantheline should be used with caution in the elderly and in all patients with autonomic neuropathy, hepatic or renal disease, hyperthyroidism, coronary heart disease, congestive heart failure, cardiac tachyarrhythmias, hypertension, or hiatal hernia associated with reflux esophagitis, since anticholinergics may aggravate this condition.

In patients with ulcerative colitis, large doses of propantheline may suppress intestinal motility to the point of producing paralytic ileus and, for this reason, may precipitate or aggravate toxic megacolon, a serious complication of the disease.

প্রতিক্রিয়া

Anticholinergics may delay absorption of other medication given concomitantly. Excessive cholinergic blockade may occur if propantheline is given concomitantly with belladonna alkaloids or synthetic and semisynthetic anticholinergic agents, narcotic analgesics such as meperidine, Type 1 antiarrhythmic drugs (e.g., disopyramide, procainamide, or quinidine), antihistamines, phenothiazines, tricyclic antidepressants, or other psychoactive drugs. Propantheline may also potentiate the sedative effect of phenothiazines. Increased intraocular pressure may result from concurrent administration of anticholinergics and corticosteroids.

Concurrent use of propantheline with slow-dissolving tablets of digoxin may cause increased serum digoxin levels. This interaction can be avoided by using only those digoxin tablets that rapidly dissolve by USP standards.

গর্ভকালীন কিংবা দুগ্ধদানকালীন অবস্থায় ব্যবহার

Pregnancy Category C. Animal reproduction studies have not been conducted with propantheline. It is also not known whether propantheline can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Propantheline should be given to a pregnant woman only if clearly needed.

Nursing Mothers: It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when propantheline is administered to a nursing woman. Suppression of lactation may occur with anticholinergic drugs.

প্রতিনির্দেশনা

Propantheline is contraindicated in patients with:

  • Glaucoma, since mydriasis is to be avoided.
  • Obstructive disease of the gastrointestinal tract (pyloroduodenal stenosis, achalasia, paralytic ileus, etc.).
  • Obstructive uropathy (e.g., bladder-neck obstruction due to prostatic hypertrophy).
  • Intestinal atony of elderly or debilitated patients.
  • Severe ulcerative colitis or toxic megacolon complicating ulcerative colitis.
  • Unstable cardiovascular adjustment in acute hemorrhage.
  • Myasthenia gravis.
বিশেষ সতর্কতা

 

মাত্রাতিরিক্ত সেবনের প্রতিক্রিয়া

The symptoms of overdosage with propantheline progress from an intensification of the usual side effects to CNS disturbances (from restlessness and excitement to psychotic behavior), circulatory changes (flushing, fall in blood pressure, circulatory failure), respiratory failure, paralysis, and coma.

Measures to be taken are (1) immediate induction of emesis or lavage of the stomach and (2) injection of physostigmine 0.5 to 2 mg intravenously, and repeated as necessary up to a total of 5 mg, and (3) monitoring of vital signs and managing as necessary.

Fever may be treated symptomatically (cooling blanket or alcohol sponging). Excitement of a degree which demands attention may be managed with thiopental sodium 2% solution given slowly intravenously or diazepam, 5 to 10 mg intravenously or 10 mg intramuscularly. In the event of progression of the curare-like effect to paralysis of the respiratory muscles, mechanical respiration should be instituted and maintained until effective respiratory action returns.

The oral LD50 of propantheline bromide is 780 mg/kg in the mouse and 370 mg/kg in the rat.

অন্যান্য ঔষধের সাথে প্রতিক্রিয়া

 

সংরক্ষণ

Store below 25° C.

প্রোকাইন্ড ট্যাবলেট এর দাম 11.20

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