Priligy

Priligy, a brand name for a formulation containing essential Dapoxetine, is widely used for various health benefits. This guide provides comprehensive information on the uses, dosage, side effects, and mechanism of action of Priligy, as well as insights into how long it takes to work. Understanding these aspects can help you make informed decisions about its use and effectiveness.

Priligy

Priligy is a selective serotonin reuptake inhibitor (SSRI) with short-acting properties that is used to treat premature ejaculation (PE). It works by increasing the levels of serotonin in the brain, which helps to delay ejaculation.

Uses

Priligy is used for the treatment of premature ejaculation (PE) to help increase the duration of intercourse and delay release of semen. It is also used to treat anxiety and depression in patients.

Mechanism of Action

Priligy works by inhibiting the serotonin transporter and preventing serotonin reuptake in the brain. This helps prolong the duration of sexual intercourse and can delay ejaculation. It can also help reduce anxiety and depression in patients.

How Long Does It Take to Work?

Priligy typically starts working within 1 to 2 hours after taking a dose. The maximum effect of the drug is usually seen in 3 to 4 hours.

Absorption

Priligy is rapidly absorbed from the gastrointestinal tract and reaches peak plasma concentrations within 1 to 2 hours. It is also highly lipophilic and has a large volume of distribution.

Route of Elimination

Priligy is mainly excreted in the urine and feces. It is metabolized by enzymes in the liver and further metabolized and excreted as metabolites.

Dosage

The recommended dose of dapoxetine for the treatment of premature ejaculation is 30 mg, taken 1 to 3 hours prior to sexual activity. It can be taken with or without food. In some cases, the dose may be increased to 60 mg if needed.

Administration

Priligy can be taken with or without food. It should be taken as prescribed by the doctor and always taken at least 1 hour before sexual activity.

Side Effects

Common side effects include nausea, drowsiness, dizziness, headache, diarrhea, and constipation.

Toxicity

Priligy is well tolerated and has a generally low risk of toxicity. However, it is important to follow your doctor's instructions and take the drug as prescribed.

Precautions

Patients taking dapoxetine should tell their doctor about any other medications they are taking, as the drug may interact with other drugs. It is also important to avoid alcohol and grapefruit juice when taking dapoxetine. Patients should also report any unexplained symptoms to their doctor.

Interaction

Priligy may interact with other medications, including MAO inhibitors, other SSRIs, and medications used to treat migraines. It is important to tell your doctor about all other medications you are taking before taking dapoxetine.

Disease Interaction

Priligy should not be taken by patients with a history of liver, kidney, or heart disease, as it may worsen the condition. Patients with cardiovascular problems should also consult their doctor before taking the drug.

Drug Interaction

Priligy may interact with certain drugs, such as MAO inhibitors, other SSRIs, anti-anxiety drugs, and medications used to treat migraines. It is important to tell your doctor about all other medications you are taking before taking dapoxetine.

Food Interaction

Grapefruit and grapefruit juice should be avoided when taking dapoxetine as it may increase the level of dapoxetine in the body. Alcohol should also be avoided when taking dapoxetine, as it may increase the side effects of the drug.

Pregnancy Use

Priligy should not be used during pregnancy as it may cause harm to the unborn baby. Women who are pregnant or breastfeeding should consult their doctor before taking the drug.

Lactation Use

Priligy is not recommended for use in breastfeeding women, as it may pass into breastmilk and cause harm to the baby. Women who are breastfeeding should consult their doctor before taking the drug.

Acute Overdose

In cases of acute overdose, vomiting, drowsiness, and confusion can occur. If an overdose is suspected, the patient should seek medical attention immediately.

Contraindication

Priligy should not be used in patients with a known hypersensitivity to the drug or any of its ingredients. It should also not be used in patients who have taken monoamine oxidase inhibitors (MAOIs) within 14 days of taking dapoxetine.

Use Direction

Priligy should be taken as directed by the doctor. The recommended dose is 30 mg, taken 1 to 3 hours before sexual activity. In some cases, the dose may be increased to 60 mg if needed.

Storage Condition

Priligy should be stored at room temperature in a cool, dry place, away from direct sunlight and heat. The tablets should be kept out of reach of children and pets.

Volume of Distribution

The volume of distribution of dapoxetine is approximately 37 L/kg, which is indicative of a large distribution volume.

Half Life

The half-life of dapoxetine is approximately 19 hours, which is relatively short compared to other SSRIs.

Clearance

The clearance of dapoxetine is approximately 0.5 L/hr/kg, implying a relatively slow clearance rate.

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