Premol Plus

Premol Plus Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Premol Plus is a brand name. Its generic name is Paracetamol + Caffeine.

Introduction

Premol Plus is a combination drug used for different types of pain and to reduce fever. It belongs to the group of drugs called analgesics and antipyretics. It is an over-the-counter medication available in multiple forms such as tablets, capsules, liquids, suspensions and injections.

Uses of Premol Plus

Premol Plus is commonly used for relief from mild to moderate pain, such as headaches, muscle aches, dental pain, menstrual cramps, and flu. It is also used for reducing fever and as a nighttime sleep aid.

Mechanism of Action

Paracetamol is a centrally acting analgesic and antipyretic. It works by inhibiting the synthesis of substances called prostaglandins in the brain and spinal cord. These prostaglandins are involved in the transmission of pain signals to the brain. Caffeine works by constricting the blood vessels and increasing the pain threshold, thus decreasing the pain perception in the brain.

How Long Does It Take To Work?

Premol Plus usually starts to work within 20-30 minutes when taken orally. Its effect can last up to 6 hours.

Absorption

Premol Plus is rapidly and nearly completely absorbed from the gastrointestinal tract.

Route of Elimination

Premol Plus is primarily eliminated through the kidneys, where it is metabolized to inactive metabolites which are then excreted in the urine.

Dosage

The usual dose of Premol Plus is one or two tablets or capsules every 4-6 hours. The maximum dose in 24 hrs is 8 tablets or capsules. It is advised to not exceed the maximum dose as it can cause side effects.

Administration

Premol Plus should be taken orally, with or without food. It can be taken with a glass of water.

Side Effect

• Nausea
• Vomiting
• Stomach pain
• Headache
• Dizziness
• Rash

Toxicity

Overdose of Premol Plus can lead to serious side effects such as liver and kidney damage. Taking more than the recommended dose can also cause poisoning and can be fatal.

Precaution

• Patients with liver or kidney disease, asthma, high blood pressure, or heart diseases should not use Premol Plus
• Women who are pregnant or breastfeeding should avoid the use of this medication.

Interaction

Premol Plus can interact with other medications, such as anticoagulants and antidiabetic drugs, and increase the risk of side effects. It can also interact with alcohol and increases the risk of liver damage.

Disease Interaction

Premol Plus can interact with certain conditions and worsen the symptoms, such as liver or kidney disease, asthma, high blood pressure, and heart diseases.

Drug Interaction

Premol Plus can interact with other drugs and increase the risk of side effects. These drugs include anticoagulants, diuretics, and antidiabetic drugs.

Food Interactions

Foods such as alcohol, grapefruit juice, caffeine-containing drinks, and spicy foods may interact with Premol Plus and increase the risk of side effects.

Pregnancy Use

Premol Plus should be avoided during pregnancy, as its safety has not yet been established.

Lactation Use

It is not recommended to take Premol Plus while breastfeeding, as its safety has not yet been established.

Acute Overdose

Acute overdose of Premol Plus can cause severe symptoms such as nausea, vomiting, abdominal pain, drowsiness, sweating and confusion. It can also lead to liver and kidney damage.

Contraindication

Premol Plus should not be taken in case of hypersensitivity to any of its components. Also, it is contraindicated in patients with certain medical conditions such as liver or kidney diseases, asthma, high blood pressure, and heart diseases.

Use Direction

As recommended by the doctor, Premol Plus should be taken every 4-6 hours for relief from pain or fever. It can be taken with or without food.

Storage Condition

Premol Plus should be stored at room temperature away from direct sunlight, moisture, and heat. Keep out of reach of children.

Volume of Distribution

The volume of distribution of Premol Plus is not known.

Half Life

The half life of Premol Plus is 3-4 hours.

Clearance

The clearance of Premol Plus in the body is not known.

Here you find in details version of Premol Plus

Some Frequently Asked Questions About Premol Plus

What is Premol Plus?

Premol Plus is a combination of two over-the-counter medications used to relieve pain and fever. Paracetamol is an analgesic used to reduce the feeling of pain and Caffeine is a stimulant that can help improve alertness.

What are the most common side effects of Premol Plus?

The most common side effects of Premol Plus include nausea, drowsiness, headache, dizziness, restlessness, and confusion.

Can I take Premol Plus if I am pregnant?

Pregnant women should not take Premol Plus, unless it is prescribed by their doctor.

Is Premol Plus safe to take for extended periods of time?

It is not recommended to take Premol Plus for extended periods of time, as long-term use may lead to an increased risk of side effects and drug interactions.

Can I take Premol Plus to help me stay awake?

No, it is not recommended to take Premol Plus for the purpose of staying awake or increasing alertness.

What is the recommended dosage for Premol Plus?

The recommended dosage for Premol Plus is 500mg to 1000mg of paracetamol, and up to 200mg of caffeine.

Can I take Premol Plus together with other medications?

Patients should consult their healthcare provider before taking Premol Plus with other medications, as drug interactions may occur.

What are the most common drug interactions associated with Premol Plus?

Drug interactions may include an increased risk of nausea, stomach pain, and appetite loss when taken with other medications such as birth control pills, antacids, and antibiotics. It is important to consult a healthcare provider before taking medications together.

Can I take Premol Plus if I have Liver Disease?

Patients with liver damage or disease should not take Premol Plus, as it can interfere with the body's ability to metabolize the active ingredients.

Can Premol Plus cause stomach pain?

Premol Plus can cause stomach pain, nausea, and vomiting if taken in high doses or if taken with other medications that can cause digestive issues.

How quickly does Premol Plus start to work?

The effects of Premol Plus start to take effect within one hour of taking the medication.

What is the maximum daily dose of Premol Plus?

The maximum daily dose of Premol Plus is not recommended beyond 2000mg of paracetamol and 400mg of caffeine.

Can I take Premol Plus if I have a history of dehydration?

Patients with a history of dehydration should seek medical advice before taking Premol Plus, as the caffeine may lead to dehydration.

What are the risks of taking too much Premol Plus?

Risks of taking too much Premol Plus include nausea, vomiting, confusion, fatigue, and liver damage. It is important to stick to the recommended dosage for best results.

What should I avoid while taking Premol Plus?

Patients should avoid alcohol consumption while taking Premol Plus, as it can increase the risk of side effects.

Can I combine Premol Plus with other over-the-counter pain relievers?

It is not recommended to take Premol Plus with other over-the-counter pain relievers as this increases the risk of side effects and drug interactions.

Can Premol Plus cause addiction?

No, Premol Plus is not known to cause addiction like other pain relievers.

Does Premol Plus interact with other substances?

Premol Plus may interact with certain substances, such as alcohol, tranquilizers and other medications, and cause an increased risk of severe side effects.

How often can I take Premol Plus?

It is recommended to take no more than two doses of Premol Plus in a 24-hour period, with at least 4 hours in between each dose.

How long does Premol Plus stay in your system?

The active ingredients in Premol Plus typically stay in your system for 4 to 6 hours.

Can I take Premol Plus for a headache?

Yes, Premol Plus can be taken for a headache. However, it is recommended to seek medical advice if the headache persists for more than 48 hours.

Can Premol Plus cause insomnia?

Yes, Premol Plus can cause insomnia if taken too close to bedtime.

Can I take Premol Plus if I have asthma?

Patients with asthma should consult their healthcare provider before taking Premol Plus, as the caffeine may trigger asthma symptoms.

Can I take Premol Plus if I have a heart condition?

Patients with a heart condition should consult their healthcare provider before taking Premol Plus, as the caffeine may cause an increase in heart rate and blood pressure.

Are there any natural alternatives to Premol Plus?

Yes, there are many natural alternatives to Premol Plus, such as ginger, turmeric, and capsaicin. Herbal teas such as chamomile and peppermint can also relieve pain and promote relaxation.

Can I take Premol Plus if I am diabetic?

Patients with diabetes should consult their healthcare provider before taking Premol Plus, as the caffeine may affect blood sugar levels.

What should I do if I take too much Premol Plus?

If a patient takes too much Premol Plus, they should seek medical advice immediately, as it can cause serious health issues including liver damage.

Can I take Premol Plus for inflammation?

No, Premol Plus is not recommended for the relief of inflammation.

Are there any foods that should be avoided while taking Premol Plus?

It is recommended to avoid foods high in caffeine such as chocolate, tea, and coffee while taking Premol Plus.

Can I take Premol Plus if I have a stomach ulcer?

Patients with a stomach ulcer should consult their healthcare provider before taking Premol Plus, as it may worsen the condition.

Are there any side effects associated with long-term use of Premol Plus?

Yes, long-term use of Premol Plus may cause an increased risk of side effects such as stomach pain, nausea, dizziness and liver damage.

Can I take Premol Plus if I am breastfeeding?

It is not recommended to take Premol Plus while breastfeeding, as the active ingredients may pass into breast milk and affect the baby.

Can I take Premol Plus if I have high blood pressure?

Patients with high blood pressure should consult their healthcare provider before taking Premol Plus, as the caffeine may affect blood pressure levels.

Is it safe to take Premol Plus for a migraine?

No, it is not recommended to take Premol Plus for a migraine, as it may not be effective.

What are the symptoms of an overdose of Premol Plus?

Symptoms of an overdose of Premol Plus may include nausea, vomiting, stomach pain, confusion, headache, and drowsiness.

Can I take Premol Plus for a cold?

No, Premol Plus is not recommended for the relief of cold symptoms.

Can I take Premol Plus if I have kidney disease?

It is not recommended to take Premol Plus if you have kidney disease, as the active ingredients may be difficult for the body to process.

Can I take Premol Plus if I am allergic to aspirin?

It is not recommended to take Premol Plus if you are allergic to aspirin, as the active ingredients may cause an allergic reaction.

Are there any foods that can increase the absorption of Premol Plus?

Fatty foods such as fish, nuts, and avocados can help to increase the absorption of Premol Plus in the body.

Can I take Premol Plus if I have depression?

Patients with depression should consult their healthcare provider before taking Premol Plus, as it may worsen the symptoms.

What is the difference between Paracetamol and Premol Plus?

The main difference between Paracetamol and Premol Plus is that Premol Plus includes caffeine, which can help improve alertness and reduce fatigue.