প্রেমিল এ আছে Repaglinide। প্রেমিল এর কাজঃ
প্রেমিল is indicated as an adjunct to diet and exercise to lower the blood glucose level in patients with type 2 diabetes mellitus (NIDDM) whose hyperglycaemia cannot be controlled satisfactorily by diet and exercise alone. It is also indicated for use in combination with Metformin to lower blood glucose in patients whose hyperglycaemia cannot be controlled by exercise, diet, and either প্রেমিল or Metformin alone. প্রেমিল binds to specific receptors in the cell membrane leading to the closure of ATP dependent K+ channels and the depolarisation of cell membrane. This in turn, leads to Ca++ influx, increased intracellular Ca++ and the stimulation of insulin secretion.
|Premil Tablet 1 mg in bangla|
|চিকিৎসাগত শ্রেণিঃ||Meglitinide Analogues|
|উৎপাদনকারীঃ||Beximco Pharmaceuticals Ltd|
|সর্বশেষ সম্পাদনাঃ||2020-11-20 18:15:00|
প্রেমিল stimulates release of insulin from pancreatic β-cells by inhibiting K efflux via closure of ATP regulated K channels. This results in depolarization of the cell and opening of voltage-dependent Ca channels, which increases influx of Ca into the beta cells and causes release of insulin.
প্রেমিল এ আছে Repaglinide 1 mg। প্রেমিল খাওয়ার নিয়ম নিম্নরূপঃ
প্রেমিল has to be taken just before or up to 30 minutes before the meal. প্রেমিল can be taken two, three or four times a day, depending on how many meals are taken. If a meal is missed, প্রেমিল should also be avoided. If an extra meal is taken, an extra dose of প্রেমিল should be taken with that meal. If a dose of প্রেমিল is missed, it should not be taken between meals.
Rather the usual dose should be taken before the next meal. The dose ranges from 0.5 to 4 mg before each meal. The starting dose of প্রেমিল in patients with HbA1c <8% is 0.5 mg before each meal. In patients with HbA1c >8% the starting dose is 1 or 2 mg before each meal. The dose may be increased gradually up to 4 mg before each meal.
Hypoglycaemia is possible with all blood glucose lowering drugs. If there are symptoms of low blood glucose (for example, headache, dizziness, tiredness, nervousness or shakiness, rapid heartbeat, or nausea), blood glucose should be tested right away. If it is low (less than 70 mg/dl on a home glucose meter), a simple carbohydrate food (for example, orange juice, quick dissolving sugar, candies, or glucose tablets) should be taken. If the symptoms do not go away, doctor should be informed. Some of the other common symptoms reported by patients taking প্রেমিল include cold and flu-like symptoms, diarrhoea, joint ache, and back pain. There is some evidence that oral anti-diabetic drugs may increase the risk of heart problems. But experts are not sure what the real risk is, if any, from taking oral anti-diabetic drugs.
প্রেমিল should also be used with caution in renal and hepatic insufficiency.
The dose of প্রেমিল may need to be adjusted, if taken with other medications. The possible interactions of প্রেমিল with other drugs are:
In pregnancy, safety of প্রেমিল has not been established. Hence, প্রেমিল should be used during pregnancy only if it is clearly needed. It is not known whether প্রেমিল is excreted in human milk. Because many drugs are excreted in human milk and because of potential for serious adverse reactions in nursing infants from প্রেমিল, a decision should be made whether to discontinue nursing or the drug, taking into account the importance of the drug to the mother.
প্রেমিল is contraindicated in patients with diabetic ketoacidosis, with or without coma, in patients with type I diabetes and in patients with known hypersensitivity to any of the components of the product.
Patients receiving up to 80 mg of প্রেমিল developed few adverse effects other than lowering of blood glucose. Hypoglycemia did not occur when meals were given with these high doses. Severe hypoglycemic reactions with coma, seizure or other neurological impairment occur infrequently.
Store below 25° C. Protect from moisture.
প্রেমিল ট্যাবলেট এর দাম 4.20