Polycin
Polycin Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Polycin is a brand name. Its generic name is Bacitracin Zinc + Polymyxin B Sulphate.
Introduction
Bacitracin zinc + Polymyxin B sulphate is an antibiotic combination that is used to treat topical infections caused by susceptible bacteria. It is used to treat minor skin and eye infections, such as impetigo, folliculitis, furuncles, and conjunctivitis. The medication comes in ointment or cream forms and should not be used to treat any systemic infection.
Uses for
The antibiotic combination of Bacitracin zinc + Polymyxin B sulphate is used to treat minor skin and eye infections, such as impetigo, folliculitis, furuncles, and conjunctivitis.
Mechanism of Action
Bacitracin zinc + Polymyxin B sulphate disrupts bacterial cell wall synthesis and causes cell death. Bactracin zinc interferes with the production of bacterial cell wall peptidoglycan. Polymyxin B is a polymixin antibiotic that binds to and alters the surface charge of lipid membranes and causes cell leakage.
How Long Does it Take to Work?
Most topical infections should show signs of improvement within a few days of starting treatment with Bacitracin zinc + Polymyxin B sulphate.
Absorption
The antibiotic combination is poorly absorbed through the skin, thus reducing the risk of systemic toxicity.
Route of Elimination
Bacitracin zinc + Polymyxin B sulphate is eliminated mainly through the feces. It is also metabolized in the liver, and the metabolites are excreted in the feces and urine.
Dosage
The dose of Bacitracin zinc + Polymyxin B sulphate ointment or cream depends on the type, severity, and location of the infection being treated. Refer to the product labeling for the exact dosage and administration instructions.
Administration
Clean and dry the affected skin or eye area before applying the medication. Apply a thin layer of the ointment or cream and gently rub it into the skin. Avoid contact with the eyes or other mucous membranes. Wash hands after use. Follow all instructions for proper use.
Side Effects
Common side effects of Bacitracin zinc + Polymyxin B sulphate include skin irritation, stinging, burning, and itching. Contact a healthcare provider immediately if any signs of severe allergic reaction occur, such as hives, difficulty breathing, or swelling of the face or mouth.
Toxicity
Bacitracin zinc + Polymyxin B sulphate has a low toxicity for topical use. If it is swallowed or injected intravenously, it can cause kidney and liver damage. Symptoms of toxicity include nausea, vomiting, diarrhea, and rash. If these or any other severe symptoms occur, seek medical attention immediately.
Precaution
Before using Bacitracin zinc + Polymyxin B sulphate, inform a healthcare professional of any allergies or if the patient is pregnant, nursing, or taking other medications. Avoid long-term use of the medication as it may lead to bacterial resistance. Do not use it to treat any systemic infection.
Interaction
It is important to tell a healthcare professional of all current medications before using Bacitracin zinc + Polymyxin B sulphate. It is possible that some drugs may interact, including those found in vitamins, herbal products, and over-the-counter medications. It is possible that some drugs may interact, including those found in vitamins, herbal products, and over-the-counter medications.
Disease Interaction
Bacitracin zinc + Polymyxin B sulphate may interact with certain diseases. These include diabetes, kidney disease, and liver disease. Inform a healthcare professional of any underlying medical conditions before starting treatment. It is important to note that this antibacterial combination should not be used to treat any systemic infection.
Drug Interaction
It is possible Bacitracin zinc + Polymyxin B sulphate may interact with certain drugs, including diuretics, beta-blockers, and nonsteroidal anti-inflammatory drugs. If taking any of these drugs, inform a healthcare professional before applying the medication.
Food Interactions
Bacitracin zinc + Polymyxin B sulphate is not known to interact with any foods. However, it is a good idea to inform a healthcare professional of any recent changes in diet before using the medication.
Pregnancy Use
Bacitracin zinc + Polymyxin B sulphate is not recommended for pregnant or nursing women. Speak with a healthcare provider about other treatment options for topical infections during pregnancy or breastfeeding.
Lactation Use
The antibiotic combination of Bacitracin zinc + Polymyxin B sulphate is not recommended for nursing women. Speak with a healthcare provider about other treatment options for topical infections while breastfeeding.
Acute Overdose
It is unlikely that an acute overdose would occur with Bacitracin zinc + Polymyxin B sulphate due to the low systemic absorption by the body. If an overdose is suspected, call a poison control center immediately.
Contraindication
The antibiotic combination of Bacitracin zinc + Polymyxin B sulphate is contraindicated in patients with a known allergy or hypersensitivity to any of its ingredients. It is not recommended for use in infants younger than 6 months of age.
Use Direction
To use this medication, clean and dry the affected skin or eye area before applying. Apply a thin layer of the ointment or cream and gently rub it into the skin. Avoid contact with the eyes or other mucous membranes. Wash hands after use. Follow all instructions for proper use.
Storage Condition
Bacitracin zinc + Polymyxin B sulphate should be stored at room temperature, away from direct light and heat. Keep away from children and pets.
Volume of Distribution
The volume of distribution of Bacitracin zinc + Polymyxin B sulphate is not well-documented due to its poor absorption by the body.
Half Life
The half life of Bacitracin zinc + Polymyxin B sulphate is not well-documented due to its poor absorption by the body.
Clearance
The clearance of Bacitracin zinc + Polymyxin B sulphate is not well-documented due to its poor absorption by the body.
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