Pofol
Pofol Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Pofol is a brand name. Its generic name is Propofol.
Pofol Introduction
Pofol is an intravenously administered short-acting anesthetic agent used for induction and maintenance of general anesthesia and for procedural sedation. It is a clear and colorless, oil-in-water emulsion supplied in a single-use, premixed form for intravenous administration.Uses for Pofol
Pofol is used to induce and maintain anesthesia, along with the adjuncts of nitrous oxide and oxygen. It is also used for sedation and treatment of status epilepticus.Mechanism of Action
Pofol works primarily by binding to and activating the gamma-aminobutyric acid (GABA) receptor complex. This increases chloride ion conductance, resulting in a hyperpolarization of the cell membrane, which decreases neuronal hyperexcitability and leads to sedation and decreased muscle tone.How Long Does It Take to Work
Pofol starts working immediately when it is administered intravenously. Its effects can last for a few minutes or several hours depending on the amount administered, the person's sensitivity to the drug, and the other medications given.Absorption
Pofol is administered intravenously and is not absorbed after oral administration.Route of Elimination
Pofol is metabolized primarily by the liver prior to excretion via the kidneys. Approximately 70% of the drug is excreted in the urine with the remainder being eliminated via the bile.Dosage
The recommended dose of propofol for induction of general anesthesia is 1.5 to 2.5 mg/kg body weight injected slowly over 20 to 40 seconds. Maintenance doses may be administered as required; however, 0.5 to 1.0 mg/kg body weight should not be exceeded. Intravenous bolus doses of propofol may be given in increments of 0.5 to 1 mg/kg of body weight.Administration
Pofol may be administered intravenously by slow injection over 20 to 40 seconds. It is also available as an intravenous infusion and may be used for anaesthesia or sedation. In adults, the infusion rate should not exceed 50 to 75 mg/kg/h. In paediatrics, the infusion rate should not exceed 4 mg/kg/min.Side Effect
Common side effects associated with propofol use may include injection site pain, hypotension, bradycardia, dizziness, headache, tachycardia, nausea, and vomiting. Other side effects such as yellowing of the skin and eyes (jaundice), evidence of infection at the injection site, or difficulty breathing should be reported to a doctor immediately.Toxicity
Pofol is generally well tolerated in low doses. However, at higher doses or with prolonged use propofol can accumulate in the body resulting in an increased risk of toxicity, which may include respiratory depression, hypotension (low blood pressure), arrhythmia, and heart failure.Precaution
Before using propofol, it is important to tell your doctor if you have any allergies or if you have any other medical conditions such as heart problems, asthma, liver or kidney disease, or if you are pregnant or breastfeeding.Interaction
Pofol may interact with other medications such as benzodiazepines, opioids, and neuromuscular blocking agents. The dosage of propofol may need to be adjusted.Disease Interaction
Pofol may interact with certain diseases such as liver or kidney disease, asthma, or cardiovascular disease. People with these conditions should talk to their doctor before using propofol.Drug Interaction
Pofol may interact with other drugs, such as benzodiazepines, opioids, and neuromuscular blocking agents. The dosage of propofol may need to be adjusted.Food Interaction
Pofol should not be taken with food, as this may decrease its effectiveness.Pregnancy Use
Pofol should not be used during pregnancy, as it could potentially cause harm to an unborn baby.Lactation Use
Pofol should not be used while breastfeeding as it could potentially affect the nursing baby.Acute Overdose
An acute overdose of propofol can be fatal. Overdose symptoms may include sedation, respiratory depression, hypotension, bradycardia, and coma.Contraindication
Pofol should not be used in people who are allergic to it or any of its components. It should also not be used in people with certain medical conditions such as a compromised respiratory system or liver and kidney diseases.Use Direction
Pofol should be administered in an intravenous infusion and the rate of infusion should not exceed 50 to 75 mg/kg/h in adults and 4 mg/kg/min in pediatrics. The maximum total dose should not exceed 2 mg/kg of body weight.Storage Condition
Pofol should be stored at a controlled room temperature between 25 degrees Celsius and 30 degrees Celsius and should not be frozen. It should also be stored away from direct sunlight, inquire or extreme temperatures.Volume of Distribution
The volume of distribution of propofol is approximately 0.7 to 1.5 L/kg.Half Life
The half-life of propofol is approximately 1.5 to 2.5 hours.Clearance
The clearance of propofol is approximately 0.20 to 0.25 L/h/kg.Here you find in details version of Pofol
Some Frequently Asked Questions About Pofol
What is Pofol?
Pofol is an intravenous sedative/hypnotic agent used for the induction and maintenance of general anesthesia or sedation for diagnostic or therapeutic procedures.
What medical purposes is Pofol used for?
Pofol is commonly used for anesthesia during medical procedures, such as surgery, or to induce a coma-like state in intensive care units.
What is the chemical formula for Pofol?
The chemical formula of Pofol is C12H18O.
Who manufactures Pofol?
Pofol is manufactured by AstraZeneca and pharmaceutical companies such as Hospira and Mylan.
What is the generic name for Pofol?
The generic name for Pofol is Diprivan.
Does Pofol have any side effects?
Pofol can cause some side effects such as dizziness, low blood pressure, respiratory depression, slowed heart rate, confusion, discomfort around the injection area, and non-allergic reactions like hives or itching.
Does Pofol have any contraindications?
Pofol has contraindications for use in patients with certain conditions, including allergies to existing medical conditions, medications, or foods.
What is the maximum dose of Pofol that can be safely administered?
The maximum recommended dose of Pofol is 4 mg/kg body weight/hour for adults, and 2 mg/kg body weight/hour for children.
Can Pofol be used in pediatric patients?
Yes, Pofol can be used in pediatric patients, however, lower doses must be given depending on the age and size of the patient.
Are there any conditions in which Pofol should not be used?
Pofol should not be used in patients with severe liver or kidney diseases, uncontrolled seizures, or those with a history of substance abuse.
How long does it take for Pofol to take effect?
The induction time for Pofol is approximately 20 seconds and the recovery time is about 10 minutes.
Is Pofol an opioid?
No, Pofol is not an opioid. It is a sedative-hypnotic drug.
Can Pofol be used in patients with allergies?
It is not recommended to use Pofol in patients with allergies to certain medications, foods, preservatives or dyes.
Can Pofol be used as a conscious sedation?
Yes, Pofol can be used as a conscious sedation during certain procedures, such as endoscopies or imaging studies.
What are the storage requirements for Pofol?
Pofol should be stored in a tightly sealed container. It should be stored at room temperature, away from light and moisture. It should also be kept away from children and pets.
Can Pofol be mixed with other medications?
Pofol should not be mixed with other medications and should be administered separately. If necessary, Pofol can be mixed with certain substances, such as dextrose, sodium chloride or lidocaine, but only with the direction of a healthcare provider.
Is there a risk of overdose with Pofol?
Yes, there is a risk of overdose with Pofol if too high a dose is administered or if it is taken in combination with other drugs.
What are the signs of an overdose on Pofol?
The signs of an overdose on Pofol may include changes in heart rate, difficulty breathing, confusion, loss of consciousness, and coma.
What is the difference between Pofol and midazolam?
Pofol is an intravenous sedative-hypnotic drug used for the induction and maintenance of general anesthesia or sedation. Midazolam is a short-acting benzodiazepine used for induction of anesthesia or for sedation during medical procedures.
What is the half-life of Pofol?
The half-life of Pofol is approximately 4-20 minutes.
Is Pofol compatible with breastfeeding?
It is not recommended to breastfeed while taking Pofol as it can cause drowsiness and confusion in the infant.
Can Pofol interact with other medications?
Yes, Pofol can interact with other medications, such as certain antidepressants, anticonvulsants, antihistamines, narcotics, and muscle relaxants.
What should I do if I experience an allergic reaction while taking Pofol?
If you experience an allergic reaction while taking Pofol, stop taking the medication immediately and seek medical attention.
How can I tell if Pofol is working?
Pofol may cause drowsiness, slowed breathing, and a slowed heartbeat. If you experience any of these symptoms after taking Pofol, it is working.
Can Pofol cause respiratory depression?
Yes, Pofol can cause respiratory depression in certain individuals, especially those with pre-existing respiratory conditions. This is why it is essential that Pofol is administered by a trained and certified healthcare professional.
How long does Pofol stay in the system?
The effects of Pofol can last up to an hour, however, the drug can be detectable in the body for up to 24 hours.
Is Pofol habit-forming?
Pofol is not habit-forming, however, it can cause physical and psychological dependence in some individuals.
Can Pofol cause withdrawal symptoms?
Yes, Pofol can cause withdrawal symptoms in individuals taking high doses for extended periods of time. Common withdrawal symptoms may include anxiety, seizure, tremors, and decreased tolerance to medications.
What is the difference between Pofol and opioids?
Pofol is an intravenous sedative-hypnotic drug used for the induction and maintenance of general anesthesia or sedation, whereas opioids are narcotic pain medications that can be addictive and cause physical dependence.
Are there any long-term effects of taking Pofol?
Possible long-term effects of Pofol may include headaches, depression, difficulty sleeping, nausea, and dizziness.
What precautionary measures should be taken when administering Pofol?
When administering Pofol, the healthcare provider should ensure proper dosage and patient monitoring, pay attention for signs of respiratory depression, be aware of possible allergic reactions, and be prepared to respond to any emergency that might arise.
Can Pofol be used in combination with Local Anesthesia?
Yes, Pofol can be used in combination with local anesthetics, such as lidocaine, to provide a deeper level of sedation.
Is Pofol a controlled substance?
Yes, Pofol is a Schedule 2 controlled substance in the United States.
What is the shelf life of Pofol?
The shelf life of Pofol is 2 years from the date of manufacture.
Does Pofol need to be refrigerated?
No, Pofol does not need to be refrigerated, however, it should be stored in a cool, dry place away from light and moisture.
Can Pofol be taken orally?
No, Pofol must be administered intravenously and cannot be taken orally.
Is Pofol covered by insurance?
It depends on the insurance provider. Some insurance companies may cover the cost of Pofol, while others may not.
What is the cost of Pofol?
The cost of Pofol may vary depending on the manufacturer, strength, and quantity purchased. It is best to contact your healthcare provider for more information.
What should be done in the event of an overdose on Pofol?
In the event of an overdose on Pofol, seek medical attention immediately. An antidote such as flumazenil may be administered to reverse the effects of the drug.
What is the onset and duration of action of Pofol?
The onset of action of Pofol is approximately 20 seconds, with effects lasting approximately 10 minutes.
Can Pofol cause liver damage?
Yes, there is a risk of liver damage with prolonged use of Pofol, especially in individuals with pre-existing liver disease.
Does Pofol have any interactions with alcohol?
Yes, Pofol can interact with alcohol and other sedatives, such as benzodiazepines. It is important to avoid alcohol while taking Pofol.
What is the onset and duration of action of Pofol?
The onset of action of Pofol is approximately 20 seconds, with effects lasting approximately 10 minutes.
What is the recommended dosage of Pofol?
The recommended dosage of Pofol is 2-4 mg/kg body weight/hour for adults and 0.5-2 mg/kg body weight/hour for children, depending on the age and size of the patient.
What are the potential risks associated with Pofol?
Potential risks associated with Pofol may include respiratory depression, low blood pressure, slowed heart rate, confusion, and dizziness.