Pivicil

Pivicil Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Pivicil is a brand name. Its generic name is Pivmecillinam.

Pivicil

Pivicil is an oral antibiotic which belongs to the family of penicillin. It is used to treat urinary tract infections caused by susceptible organisms like Escherichia coli, Proteus mirabilis, Klebsiella pneumonia, and Enterobacter species. Apart from that, it can also be used for treatment of gonorrhea, salmonella enteric fever, could be used along with other medicines to treat certain infections.

Uses for Pivicil

Pivicil is used to treat the following infections caused by susceptible organisms: Urinary tract infections caused by Escherichia coli, Proteus mirabilis, Klebsiella pneumonia, Enterobacter species, Skin and soft tissue infections, Respiratory tract infections, Gonococcal urethritis, Salmonella enteric fever.

Mechanism of Action

Pivicil works by interfering with the growth of bacteria by disturbing the bacterial cell wall. It is bactericidal and works by disrupting the structure of the bacterial cell wall. This action results in the death of the bacterial cells.

How Long Does it Take to Work?

The effects of pivmecillinam start to appear within 3 to 4 days of treatment. However, it is best to complete the full course of treatment even if you start to feel better after taking the first dose.

Absorption

Pivicil is rapidly and almost completely absorbed in the gastrointestinal tract.

Route of Elimination

Pivicil is excreted primarily in the urine, with approximately 85% of an oral dose being recovered in the urine unchanged.

Dosage

The usual dose of pivmecillinam is 400 mg taken orally, three times a day for 5 days. It should be taken with food to prevent stomach irritation and ensure complete absorption. Higher dosage may be used for severe infections.

Administration

Pivicil should be taken with food to prevent stomach irritation and ensure complete absorption. The capsule should be swallowed whole and not crushed or chewed.

Side Effects

Pivicil can cause some common side effects such as: nausea, vomiting, diarrhea, headache, rashes, dizziness, abdominal pain. Notify your doctor if any of these effects become severe.

Toxicity

The therapeutic index (or safety ratio) of pivmecillinam is low. In case of an overdose, seek medical attention immediately. Overdose can cause severe nausea, vomiting, and seizures.

Precautions

Before taking pivmecillinam, inform your doctor if you have any allergies or if you are taking any other medicines, such as antacids or vitamins. Also, the use of pivmecillinam should be avoided if you are pregnant or breastfeeding.

Interaction

Pivicil can interact with certain medications, such as antacids. It can also interact with certain vitamins and supplements. Inform your doctor about all medications, herbs, and supplements you are taking before taking pivmecillinam.

Disease Interaction

Pivicil should not be used if you have a history of renal impairment, hepatic impairment, or if you are allergic to penicillin. It can also interact with certain diseases, such as diabetes, so make sure to inform your doctor about any medical conditions you have before taking pivmecillinam.

Drug Interactions

Pivicil can interact with certain drugs, such as antacids. In addition, it can also interact with vitamins and supplements. Make sure to inform your doctor about all medications, herbs, and supplements you are taking before taking pivmecillinam.

Food Interactions

No specific food interactions with pivmecillinam have been seen. Make sure to take it with food to prevent stomach irritation and ensure complete absorption.

Pregnancy Use

Pivicil should be used with caution during pregnancy as it can cause harm to the unborn child. Seek medical advice before taking if you are pregnant or planning to become pregnant.

Lactation Use

Pivicil should be used with caution during lactation as it can be secreted in the breast milk. Seek medical advice before taking if you are breastfeeding.

Acute Overdose

In case of an overdose, seek medical attention immediately. Overdose can cause severe nausea, vomiting, and seizures.

Contraindication

Pivicil should not be used if you have a history of renal impairment, hepatic impairment, or if you are allergic to penicillin.

Use Direction

Take the capsule with food to prevent stomach irritation and ensure complete absorption. Swallow the whole capsule, do not crush or chew it. Do not take more than the recommended dose as it can be harmful and seek medical advice if you experience any unusual symptoms.

Storage Condition

Store pivmecillinam at room temperature, away from moisture and heat. Keep it out of the reach of children and pets.

Volume of Distribution

The volume of distribution of pivmecillinam is 0.42 – 0.97 L/kg.

Half-Life

The half-life of pivmecillinam is approximately 1.2 – 2 hours.

Clearance

The clearance of pivmecillinam is 0.48 – 0.75 L/hour/kg.

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