Pitam

Pitam Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Pitam is a brand name. Its generic name is Piperacillin + Tazobactam.

Introduction

Piperacillin and Tazobactam (Pip-Taz) is a combination antibiotic that is used to treat a variety of bacterial infections. It consists of two active ingredients, piperacillin and tazobactam, which work together to provide a longer lasting effect than either one alone. Piperacillin is a semi-synthetic penicillin and tazobactam is a beta-lactamase inhibitor.

Uses for

Piperacillin-Tazobactam is indicated for the treatment of serious infections caused by susceptible bacteria including lower respiratory tract infections, skin and skin structure infections, intra-abdominal infections, female pelvic infectious disease, gynecological infections, and complicated urinary tract infections.

Mechanism of Action

Piperacillin and tazobactam work together to inhibit the enzymes of bacteria that can inactivate the piperacillin. In other words, the tazobactam inhibits the synthesis of an enzyme produced by bacteria that can break down the piperacillin. This effect increases the amount of time that the piperacillin is able to remain active and therefore increases the potency of the antibiotic combination.

How long does it take to work

The antibiotic effects of piperacillin-tazobactam are usually noticed within 1-2 days of starting treatment. However, it may take longer for the infection to be completely eradicated. The duration of treatment is based on the patient's response to the medication, clinical outcome, and susceptibility of the infecting organism.

Absorption

Piperacillin-tazobactam is absorbed rapidly from the gastrointestinal tract, with peak concentrations occurring within one hour of administration.

Route of Elimination

Piperacillin-tazobactam is eliminated primarily in the urine by renal excretion. A small amount is eliminated through metabolism.

Dosage

The recommended dose of piperacillin-tazobactam is 4.5gm (4g piperacillin, 0.5gm tazobactam) IV every six hours for 10-14 days. Piperacillin-tazobactam may also be given as 1.5 gm (1g piperacillin, 0.5gm tazobactam) IV every 8 hours for 10-14 days.

Administration

Piperacillin-tazobactam should be administered intravenously over a minimum of 30 minutes as directed by your physician.

Side Effects

Common side effects of piperacillin-tazobactam include nausea, vomiting, diarrhea, headache, abdominal pain, and skin rash.

Toxicity

Toxicity related to piperacillin-tazobactam use is rare. If it occurs, it is usually seen in patients with pre-existing kidney disease.

Precaution

Patients with a known hypersensitivity to penicillin or beta-lactam drugs and those with a history of kidney or liver disease should use piperacillin-tazobactam with caution.

Interaction

Piperacillin-tazobactam may interact with other medications, including phenytoin, probenecid, methicillin, and sulfamethoxazole.

Disease Interaction

Patients with pre-existing immune deficiencies should use piperacillin-tazobactam with caution.

Drug Interaction

Piperacillin-tazobactam can interact with other medications, including antacids, probenecid, and amphotericin B.

Food Interaction

Patients should not take piperacillin-tazobactam with food. If taken with food, absorption may be decreased and effectiveness decreased.

Pregnancy Use

Piperacillin-tazobactam is classified as FDA pregnancy category B, meaning it is not expected to be harmful to an unborn baby.

Lactation Use

Piperacillin-tazobactam is excreted in breast milk and should be used with caution in breastfeeding mothers.

Acute Overdose

Signs of acute overdose include nausea, vomiting, diarrhea, and abdominal pain. Treatment is supportive care, and dialysis may be needed in severe cases.

Contraindication

Piperacillin-tazobactam is contraindicated in patients with known hypersensitivity to piperacillin or tazobactam or to any of the penicillins or cephalosporins.

Use Directions

Piperacillin-tazobactam should be administered intravenously by an infusion over 30 minutes. Do not mix with dextrose solutions. Do not administer intramuscularly.

Storage Condition

Store at room temperature away from light and moisture.

Volume of Distribution

The volume of distribution of piperacillin-tazobactam is about 11L.

Half Life

The half-life of piperacillin-tazobactam is approximately 1-1.5 hours.

Clearance

The clearance of piperacillin-tazobactam is approximately 11L/hour.

Here you find in details version of Pitam

Some Frequently Asked Questions About Pitam

What is Pitam?

Piperacillin/tazobactam, sold under the brand name Tazocin, is a combination of two antibiotics, piperacillin and tazobactam, used to treat a wide range of bacterial infections. Pipracillin is a penicillin-like antibiotic and tazobactam is a beta-lactamase inhibitor.

What is Pitam used for?

Piperacillin/tazobactam is used to treat a wide range of bacterial infections, such as pneumonia, skin and urinary tract infections, and intra-abdominal infections. The combination of two different antibiotics in one drug is thought to provide a wider range of coverage than either drug alone.

How does Pitam work?

Piperacillin binds to penicillin-binding proteins, which are involved in the synthesis of the bacterial cell wall. Tazobactam is a beta-lactamase inhibitor, which prevents bacteria from destroying piperacillin by inactivating the enzyme beta-lactamase. Combining piperacillin and tazobactam means the antibiotic is active against bacteria that produce beta-lactamase.

What are the side effects of Pitam?

Common side effects of piperacillin/tazobactam include rash, itching, nausea, vomiting, abdominal pain, and diarrhea. While these side effects usually don't require medical attention, if they do become bothersome, contact your doctor.

Is it safe to take Pitam during pregnancy?

Piperacillin/tazobactam is generally not recommended for use in pregnant women. If you're pregnant and need an antibiotic, your doctor can help you decide if it's safe for you to take this medication.

What are the most common drug interactions with Pitam?

The most common drug interactions with piperacillin/tazobactam are with warfarin (Coumadin) and methotrexate. Taking piperacillin/tazobactam with either of these drugs may increase the risk of bleeding. You should tell your doctor about all the medications you take, including vitamins, minerals, supplements, and over-the-counter drugs.

What is the usual dose of Pitam?

The usual dose of piperacillin/tazobactam is 1 to 2 g intravenously every 8 to 12 hours. It is important to follow the directions of your doctor about how to take this medication, and to not take more or less than prescribed. Talk to your doctor if you experience any changes in your symptoms.

What should I do if I miss a dose of Pitam?

If you miss a dose of piperacillin/tazobactam, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses to make up for a missed one.

What happens if I overdose on Pitam?

If you think you have overdosed on piperacillin/tazobactam, call your doctor immediately or go to the nearest emergency room right away. Overdose symptoms may include nausea, vomiting, abdominal pain, and unusual tiredness or confusion.

Is Pitam available over-the-counter?

No, piperacillin/tazobactam is not available over-the-counter. It is an injections that must be prescribed by a doctor.

Does Pitam interact with alcohol?

There are no known interactions between piperacillin/tazobactam and alcohol. However, drinking alcohol while taking any type of medication can increase the risk of side effects, so it is best to avoid drinking alcohol during this time.

Does Pitam need to be refrigerated?

No, piperacillin/tazobactam does not need to be refrigerated. However, it should be stored at room temperature out of direct sunlight.

Can Pitam be used to treat bacterial infections in children?

Yes, piperacillin/tazobactam is frequently used to treat bacterial infections in children. It is important to give the correct dose of the medication at the correct time, as recommended by your child's doctor.

What are the possible drug interactions with Pitam?

Piperacillin/tazobactam may interact with other medications, such as warfarin (Coumadin), methotrexate, and birth control pills. Be sure to tell your doctor about all the medications you take, including vitamins, minerals, supplements, and over-the-counter drugs. Your doctor will be able to determine if piperacillin/tazobactam is safe for you to take.

Does Pitam interact with herbal supplements?

Piperacillin/tazobactam may interact with some herbal supplements and natural remedies. Before taking any herbal remedies with piperacillin/tazobactam, make sure to check with your doctor. They can advise you if the supplement is safe to take with the medication.

Is Pitam safe for people with allergies?

People with allergies should check with their doctor before taking piperacillin/tazobactam as the drug may cause an allergic reaction. Symptoms of an allergic reaction may include rash, hives, itching, difficulty breathing, chest tightness, and swelling of the face, lips, or tongue.

Does Pitam have any food or drug interactions?

Yes, piperacillin/tazobactam can interact with certain foods and drugs. You should tell your doctor about all the medications you are taking, including vitamins, minerals, supplements, and over-the-counter drugs, as well as any foods that could interact with the medication.

Can Pitam be used to treat fungal infections?

No, piperacillin/tazobactam is not effective in treating fungal infections and should not be used for this purpose. If you have a fungal infection, your doctor may prescribe an antifungal medication for you instead.

Is Pitam safe for people with kidney problems?

People with kidney problems should talk to their doctor before taking piperacillin/tazobactam. Your doctor can adjust the dose of the medication according to your individual kidney function.

Is Pitam safe to take long term?

Piperacillin/tazobactam is generally safe to take long term, if it is used as prescribed by your doctor. Talk to your doctor about any risks associated with taking piperacillin/tazobactam for a long period of time.

Can Pitam be used to treat a sinus infection?

Yes, piperacillin/tazobactam is commonly used to treat a sinus infection. Your doctor may also prescribe other medications such as decongestants or antihistamines to reduce your symptoms.

Does Pitam interact with other antibiotics?

Piperacillin/tazobactam may interact with other antibiotics, leading to an increase or decrease in the effectiveness of either drug. Be sure to tell your doctor about all the medications you take, including antibiotics. They can determine if it is safe for you to take piperacillin/tazobactam with other medications.

Can I take Pitam for a sore throat?

No, piperacillin/tazobactam is not an effective treatment for a sore throat. For a sore throat that is caused by a bacterial infection, your doctor may prescribe another antibiotic, such as amoxicillin.

Can Pitam be used to treat an ear infection?

Yes, piperacillin/tazobactam is often used to treat an ear infection. Your doctor may also prescribe other medications, such as a decongestant or antihistamine, to help reduce symptoms.

Does Pitam need to be taken with food?

No, piperacillin/tazobactam does not need to be taken with food. However, it is important to follow the instructions of your doctor about how to take the medication.

Can I drink alcohol while taking Pitam?

No, you should not drink alcohol while taking piperacillin/tazobactam. Alcohol can increase the risk of side effects, so it is best to avoid drinking while taking this medication.

Does Pitam cause nausea?

Yes, piperacillin/tazobactam can cause nausea as a side effect. If you experience nausea while taking this medication, talk to your doctor about ways to reduce the nausea.

How long does it take for Pitam to work?

Piperacillin/tazobactam usually starts to work within the first few days of use, but it may take longer to see the full effects. It is important to take this medication as prescribed, and for the full length of time prescribed, to make sure that all bacteria is eliminated.

What is the usual length of treatment with Pitam?

The usual length of treatment with piperacillin/tazobactam is 5 to 10 days, depending on the type of infection. It is important to take the medication for the full length of time prescribed by your doctor in order to make sure that all bacteria is eliminated.

Are there any other uses for Pitam?

Yes, in addition to treating bacterial infections, piperacillin/tazobactam may be used before or during certain surgeries to help prevent infection. Talk to your doctor about the risks and benefits of using this medication in this way.

Is Pitam safe to use in children?

Yes, piperacillin/tazobactam is generally safe to use in children, but it is important to give the correct dose of the medication at the correct time, as recommended by your child's doctor. Be sure to watch for any possible side effects, such as rash, nausea, vomiting, and diarrhea.

How should Pitam be stored?

Piperacillin/tazobactam should be stored at room temperature out of direct sunlight. Keep this medication away from heat and moisture, and make sure to keep the bottle or vial tightly closed when not in use.