Pendoril Plus 4

Pendoril Plus 4 Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Pendoril Plus 4 is a brand name. Its generic name is Indapamide + Perindopril.

Introduction

Indapamide and Perindopril are medications that are used in combination to treat hypertension (high blood pressure) in adults. It helps to reduce the risk of complications from hypertension such as stroke or heart attack.

Uses for

Indapamide and Perindopril is used to treat hypertension (high blood pressure) in adults.

Mechanism of Action

Indapamide works by reducing sodium and water levels in the blood, which in turn causes the blood vessels to relax for improved blood flow. Perindopril is an ACE inhibitor that helps to further reduce blood pressure by blocking the enzyme that produces angiotensin, a hormone involved in regulating blood pressure.

How Long Does It Take to Work?

For most people, the effects of Indapamide and Perindopril will be noticeable within two hours. However, it may take up to four weeks for the drug to reach its peak effectiveness in controlling blood pressure.

Absorption

Indapamide is absorbed quickly from the gastrointestinal tract and reaches peak blood levels within 1.6 hours. Perindopril is also rapidly absorbed from the gastrointestinal tract and reaches peak levels in 4-6 hours.

Route of Elimination

Indapamide and perindopril are both excreted primarily in the urine. Indapamide is metabolized by the liver while perindopril is metabolized by the kidney.

Dosage and Administration

The usual dosage of Indapamide and Perindopril is 1.25/2.5 mg once daily. Your doctor may adjust your dosage if you experience side effects or if your condition worsens. It is important to take the medication exactly as prescribed.

Side Effects

Common side effects of Indapamide and Perindopril include dizziness, headaches, muscle cramps, nausea, and problems with breathing. More serious side effects may include fainting, chest pain, flu-like symptoms, confusion, and fever. If you experience any of these symptoms, contact your doctor immediately.

Toxicity

Indapamide and Perindopril can be toxic if taken in large doses or for an extended period of time. Overdose symptoms may include confusion, drowsiness, feeling faint, irregular heartbeat, and low blood pressure. If you think you have taken too much of this medicine, contact your doctor or local poison control center right away.

Precautions

It is important to tell your doctor about any other medications and supplements, especially if they are aspirin, potassium, or any ACE inhibitors, before starting Indapamide and Perindopril. It is also important to tell your doctor if you are pregnant, breastfeeding, have kidney or liver disease, or have a history of allergies.

Interactions

Indapamide and Perindopril may interact with certain medications to increase or decrease the effectiveness of the drug. Make sure to tell your doctor and pharmacist about any medications or supplements you are taking before starting Indapamide and Perindopril. It is important to follow the instructions of your doctor or pharmacist when taking this medication.

Disease Interactions

Indapamide and Perindopril may worsen certain conditions, including diabetes, lupus, scleroderma, and angioedema. It is important to discuss any chronic illness with your doctor before starting this medication.

Drug Interactions

Indapamide and Perindopril may interact with other medications, including NSAIDs, aspirin, warfarin, lithium, and diuretics. Make sure to tell your doctor and pharmacist about any medications or supplements you are taking before starting Indapamide and Perindopril. It is important to follow the instructions of your doctor or pharmacist when taking this medication.

Food Interactions

There are no known food interactions when taking Indapamide and Perindopril. However, it is important to check with your doctor or pharmacist about any foods that may interact with the medication.

Pregnancy Use

Indapamide and Perindopril should be used during pregnancy only if the potential benefit outweighs the potential risk. Make sure to talk to your doctor about the risks and benefits of taking this medication during pregnancy.

Lactation Use

Indapamide and Perindopril passes through breast milk, so nursing mothers should avoid using this medication. Talk to your doctor about how to safely take this medication if you are breastfeeding.

Acute Overdose

An overdose of Indapamide and Perindopril can be fatal. If you or someone you are with has overdosed on this medication, contact your local poison control center right away or seek emergency medical attention.

Contraindication

Indapamide and Perindopril is contraindicated in patients with anuria, lower urinary tract obstruction, severe hypotension, hyperkalemia, pregnancy or lactation, or hypersensitivity or allergy to the drug.

Use Directions

Indapamide and Perindopril should be taken as directed by a healthcare provider. The usually dosage is 1.25/2.5 mg once daily. It may take up to four weeks for the drug to reach its peak effectiveness in controlling blood pressure.

Storage Condition

Indapamide and Perindopril should be stored at room temperature and away from moisture and heat. Do not let it freeze. Keep the medication away from children.

Volume of Distribution

The volume of distribution of Indapamide and Perindopril is not known.

Half Life

Indapamide has a half-life of approximately 10 hours, while perindopril has a half-life of approximately 17 hours.

Clearance

Indapamide and Perindopril are both rapidly and completely cleared from the body by renal and hepatic excretion. The clearance of Indapamide is approximately 42 mL/min/1.73m2, while the clearance of Perindopril is approximately 1.6 mL/min/1.73m2.

Here you find in details version of Pendoril Plus 4

Some Frequently Asked Questions About Pendoril Plus 4

What is Pendoril Plus 4?

Pendoril Plus 4 is a combination medicine used to treat high blood pressure (hypertension), reduce the risk of a stroke, and to slow down long term kidney damage due to diabetes.

What are the side effects of taking Pendoril Plus 4?

Common side effects of taking Pendoril Plus 4 include dizziness, headache, tiredness, and a decrease in sexual ability. More serious side effects include low blood pressure, kidney problems, and rash.

What is the recommended dosage of Pendoril Plus 4?

The recommended dosage for high blood pressure usually starts with 1.25 mg of Indapamide and 4 mg of Perindopril per day, and can be adjusted by your doctor according to your blood pressure goals. Your doctor may also prescribe a second medicine if necessary.

Is it safe to take Pendoril Plus 4 while pregnant?

Pendoril Plus 4 is generally not recommended for use during pregnancy. If you are pregnant or planning to become pregnant, talk to your doctor before starting this medicine.

Does Pendoril Plus 4 cause weight gain?

Weight gain is not a common side effect of taking Pendoril Plus 4. However, if you have noticed an increase in your weight while taking this medicine, you should contact your doctor.

What should I do if I miss a dose of Pendoril Plus 4?

If you miss a dose of Pendoril Plus 4, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double a dose to make up for a forgotten one.

Can I take Pendoril Plus 4 while breast-feeding?

Pendoril Plus 4 can pass into breast milk. Therefore, it is not recommended to take this medicine while breastfeeding as it may harm the infant. Talk to your doctor before taking this medicine while breast-feeding.

Is it safe to take Pendoril Plus 4 with other medications?

Pendoril Plus 4 may interact with certain other drugs. Always inform your doctor about all other medicines that you are taking while taking this medicine. Do not start, stop, or change the dosage of any medication without involving your doctor.

Can I take ibuprofen with Pendoril Plus 4?

Yes, you can take ibuprofen with Pendoril Plus 4. However, it is important to talk to your doctor before doing so, as both medications can have side effects, and their interaction may cause serious health complications.

Is it safe for an elderly person to take Pendoril Plus 4?

It is generally safe for elderly people to take Pendoril Plus 4. However, elderly people may be more sensitive to the side effects of this medicine and should be monitored for any changes in their health. Talk to your doctor before taking this medicine if you are elderly.

What is the best time to take Pendoril Plus 4?

Pendoril Plus 4 should usually be taken once a day, in the morning. The best time to take this medicine is when you wake up, about 30 minutes before breakfast. Make sure to take it at the same time each day as this will help you remember it.

How long does it take for Pendoril Plus 4 to work?

It usually takes about 2-4 weeks for Pendoril Plus 4 to reach its full effect. It is important to take this medicine as prescribed by your doctor and to not stop it or change the dose without consulting your doctor.

What should I do if I experience a serious side effect while taking Pendoril Plus 4?

If you experience any serious side effects while taking Pendoril Plus 4, contact your doctor immediately. Serious side effects may include a rapid heartbeat, fever, confusion, yellowing of the skin or eyes, or extreme tiredness.

What happens if I overdose on Pendoril Plus 4?

If you overdose on Pendoril Plus 4, seek emergency medical help immediately. An overdose of this medicine can be life-threatening and may cause serious side effects such as fainting, drowsiness, confusion, or seizures.

Is Pendoril Plus 4 safe for people with liver disease?

Pendoril Plus 4 is generally not recommended for use by people with liver disease. If you have liver disease, talk to your doctor before taking this medicine, as it may cause further liver damage.

Does Pendoril Plus 4 help reduce a person's risk for a stroke?

Yes, Pendoril Plus 4 can help reduce your risk for stroke. This medicine works by reducing the force of the blood pushing against the arteries, which can reduce the risk of a stroke.

Does Pendoril Plus 4 help control high blood pressure?

Yes, Pendoril Plus 4 can help control high blood pressure. This medicine works by reducing the force of the blood pushing against the arteries, which can help to lower and control your blood pressure.

What should I do if I experience dizziness while taking Pendoril Plus 4?

If you experience dizziness while taking Pendoril Plus 4, it is important to take your time when standing up. Dizziness is a common side effect of this medicine and it may worsen when you stand up too quickly. If the dizziness persists, contact your doctor.

How long should I take Pendoril Plus 4 for?

The length of time you should take Pendoril Plus 4 depends on the severity of your condition and your response to the medicine. Talk to your doctor about how long you should take this medicine for.

What is the difference between Indapamide and Perindopril?

Indapamide is a diuretic (water pill) which helps reduce blood pressure by helping the body get rid of excess fluid. Perindopril is an ACE inhibitor which works by relaxing blood vessels and improving blood flow, which also helps reduce blood pressure.

What is the recommended dosage of Pendoril Plus 4 for high cholesterol?

Pendoril Plus 4 is not usually recommended for treating high cholesterol. Talk to your doctor about alternatives for treating high cholesterol.

Who should not take Pendoril Plus 4?

Pendoril Plus 4 is not recommended for people with a known allergy to any of the active ingredients in this medicine. This medicine is also not recommended for people with certain pre-existing medical conditions such as severe, uncontrolled high blood pressure, kidney disease, diabetes, or liver disease.

Can I take Pendoril Plus 4 with alcohol?

It is usually not recommended to take Pendoril Plus 4 with alcohol, as it can increase the risk of side effects. Talk to your doctor about drinking alcohol while taking this medicine.

Can I take Pendoril Plus 4 while taking other prescription medications?

Pendoril Plus 4 can interact with certain other medications. Always inform your doctor about all other medicines that you are taking while taking this medicine. Do not start, stop, or change the dosage of any medication without involving your doctor.

Can I buy Pendoril Plus 4 over the counter?

No, Pendoril Plus 4 is only available with a prescription from your doctor. Talk to your doctor about your blood pressure goals and to see if this medicine is right for you.

Can Pendoril Plus 4 be used to treat erectile dysfunction?

No, Pendoril Plus 4 is not recommended for treating erectile dysfunction. This medicine may cause a decrease in sexual ability, and is not intended for the treatment of sexual dysfunction.

What other conditions can Pendoril Plus 4 be used to treat?

Pendoril Plus 4 can be used to treat high blood pressure, reduce the risk of a stroke, and slow down long term kidney damage due to diabetes. Talk to your doctor before taking this medicine for any other medical conditions.

I have a history of kidney disease, can I take Pendoril Plus 4?

Pendoril Plus 4 is not recommended for people with a history of kidney disease. If you have kidney disease, talk to your doctor before taking this medicine, as it may aggravate your condition.

Can I take Pendoril Plus 4 while taking antibiotics?

Yes, you can take Pendoril Plus 4 while taking antibiotics. However, it is important to talk to your doctor before doing so, as both medications can have side effects, and their interaction may cause serious health complications.

What should I do if I experience nausea while taking Pendoril Plus 4?

If you experience nausea while taking Pendoril Plus 4, talk to your doctor. Nausea is a common side effect of this medicine and may be improved with certain lifestyle changes or other medications suggested by your doctor.

Does Pendoril Plus 4 interact with any foods?

Pendoril Plus 4 may interact with certain foods such as grapefruit and grapefruit juice. Talk to your doctor about any possible interactions between this medicine and the foods you eat.

Can I drive or operate machinery while taking Pendoril Plus 4?

It is not recommended to drive or operate machinery while taking Pendoril Plus 4, as it may cause dizziness and drowsiness. If you do need to drive or operate machinery, make sure you do it with caution and do not take any risks.

Can Pendoril Plus 4 reduce the risk of a heart attack?

Yes, Pendoril Plus 4 can help reduce the risk of a heart attack. This medicine works by reducing the force of the blood pushing against the arteries, which can reduce the risk of a heart attack.

Does Pendoril Plus 4 cause hair loss?

Hair loss is not a common side effect of taking Pendoril Plus 4. However, if you have noticed a sudden decrease in your hair while taking this medicine, you should contact your doctor.

Can Pendoril Plus 4 help reduce the risk of a stroke in people with diabetes?

Yes, Pendoril Plus 4 can help reduce the risk of a stroke in people with diabetes. This medicine works by reducing the force of the blood pushing against the arteries, which can reduce the risk of a stroke.

Can I take Pendoril Plus 4 while taking other medications for high blood pressure?

Pendoril Plus 4 can interact with certain other medications. Talk to your doctor before taking this medicine with any other medications for high blood pressure.

Can Pendoril Plus 4 help improve kidney function?

Yes, Pendoril Plus 4 can help improve kidney function by reducing the blood pressure in the vessels leading to the kidneys. This can help to slow down any long term damage to the kidneys due to diabetes.

Can Pendoril Plus 4 cause dry mouth?

Dry mouth is a common side effect of taking Pendoril Plus 4. If you experience dry mouth while taking this medicine, try drinking more water and avoiding sugary or acidic foods and drinks. If the problem persists, talk to your doctor.