Pendoril

Pendoril Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Pendoril is a brand name. Its generic name is Perindopril.

Introduction

Pendoril is a pro-drug angiotensin converting enzyme (ACE) inhibitor used to treat hypertension, heart failure, and decreases the risk of myocardial infarction. It is well tolerated and associated with few adverse effects. The drug is used to prevent and treat certain clinical conditions.

Uses

Pendoril is used to:

• Lower high blood pressure (hypertension)
• Decrease the risk of myocardial infarction in people who have already had one
• Treat certain heart conditions, including left ventricular hypertrophy and heart failure

Mechanism of Action

Pendoril works by blocking the action of the angiotensin-converting enzyme (ACE) in the body. This enzyme helps to produce a hormone called angiotensin II in the body, which constricts blood vessels and increases blood pressure. By blocking the action of ACE, perindopril prevents the production of angiotensin II, allowing the blood vessels to relax and the blood pressure to decrease.

How Long Does it Take to Work?

Most patients will notice a decrease in their blood pressure after two to four weeks of taking perindopril. It may take up to three months for the full effects of Pendoril to be seen.

Absorption

Pendoril is rapidly and completely absorbed in the GI tract, with maximum plasma concentrations reached within 1 to 2 hours. It is less than 25% bound to plasma proteins.

Route Of Elimination

Pendoril is rapidly and completely metabolized in the liver, with the metabolites being eliminated mainly through the biliary system.

Dosage

Pendoril is available in dosing strengths of 4 mg, 8 mg, and 16 mg and is taken orally in tablet form. The usual starting dose for an adult is 4mg once daily but may be increased to 8 or 16mg once daily depending on what condition is being treated.

Administration

Pendoril should be taken orally with a glass of water. It can be taken with or without food. The tablets should not be crushed, chewed or broken before taking.

Side Effects

Pendoril may cause side effects, such as headache, dizziness, tiredness, nausea, diarrhea, and coughing. Other common side effects include allergic reaction (rash, hives, itching, difficulty breathing), abdominal pain, and chest pain. Some patients may also experience a decrease in kidney function. If you experience any side effects, it is important to contact your doctor immediately.

Toxicity

Pendoril has a low risk of overdose. Symptoms of overdose include nausea, vomiting, diarrhea, hypotension, and renal failure. If you suspect an overdose, contact your doctor immediately.

Precaution

It is important to tell your doctor if you are pregnant, planning to become pregnant, breastfeeding, taking any medications, have pre-existing medical conditions, taking any herbal supplements, etc. before taking Pendoril. Pendoril can possibly interact with other medications, so it is also important to inform your doctor of any other medications you are taking.

Interaction

Pendoril may interact with other medications, including diuretics, anticoagulants, and non-steroidal anti-inflammatory drugs (NSAIDs). Caution must be taken when taking Pendoril with any other medication. It may also interact with certain foods, herbs, supplements, and alcohol.

Disease Interaction

Pendoril may interact with certain diseases, such as kidney or liver disease, diabetes, and heart disease. It may also be necessary to adjust certain medications or dosages. Tell your doctor about any diseases that you may have.

Drug Interaction

Pendoril may interact with certain drugs, including diuretics, anticoagulants, non-steroidal anti-inflammatory drugs (NSAIDs), angiotensin receptor blockers, and calcium channel blockers. Drug interaction must be taken into consideration when taking Pendoril. Tell your doctor about any drugs you are taking.

Food Interactions

Pendoril may interact with certain foods, such as salt or potassium-rich foods. Tell your doctor about any dietary restrictions or food allergies that you may have.

Pregnancy Use

Pendoril has been classified as an FDA pregnancy category D drug. It is not recommended for use during pregnancy, as it has been shown to have an increased risk of harm to the fetus.

Lactation Use

Pendoril can pass into breast milk and may cause harm to nursing infants. It is not recommended for use while breastfeeding.

Acute Overdose

Symptoms of an acute Pendoril overdose include hypotension, dizziness, nausea, vomiting, and renal failure. If you suspect an overdose, contact your doctor immediately.

Contraindication

Pendoril is contraindicated in patients with a known hypersensitivity or allergy to perindopril or any of its components, as well as in patients with severe kidney or liver disease.

Dosage Direction

Pendoril is available in the form of tablets or capsules in the following strengths: 4mg, 8mg, and 16mg. The usual starting dose is 4mg orally once daily. The dose may be increased, if necessary, to 8mg or 16mg once daily.

Storage Conditions

Pendoril should be stored at room temperature, away from direct light and moisture. Do not store in the bathroom. Keep all medication out of reach of children.

Volume of Distribution

Pendoril has a volume of distribution of approximately 0.3 L/kg. It is less than 25% bound to plasma proteins.

Half Life

The average elimination half-life of Pendoril is approximately 10-12 hours.

Clearance

Pendoril has a clearance of approximately 0.3 L/hr/kg.

Here you find in details version of Pendoril

Some Frequently Asked Questions About Pendoril

What is Pendoril?

Pendoril is an ACE (angiotensin converting enzyme) inhibitor used to treat high blood pressure and to prevent heart attack in patients with coronary artery disease.

How does Pendoril work?

Pendoril works by blocking the action of a chemical messenger (angiotensin) in your body, which causes your blood vessels to relax and your blood pressure to lower.

What are the side effects of taking Pendoril?

Common side effects include headache, dizziness, fatigue, cough, nausea, and diarrhea. More serious side effects may include allergic reactions, decreased blood pressure, kidney problems, and electrolyte imbalances.

Can I take Pendoril with other medications?

Yes, Pendoril can be taken with other medications, but you should always consult your doctor before taking any new medications.

What does Pendoril look like?

Pendoril comes in the form of tablets and is usually white or off-white in color. The tablets are scored and come in two strengths: 4mg and 8mg.

When should I take Pendoril?

Pendoril should be taken once a day, with or without food. It is important to take your dose at the same time every day.

Is Pendoril safe for long-term use?

Yes, Pendoril is safe for long-term use when taken as directed by your doctor. However, as with any medication, it’s important to check with your doctor for regular check-ups to ensure the medication is working properly and is not causing any serious side effects.

Will Pendoril help my heart attack?

Yes, Pendoril has been shown to reduce the risk of heart attack, stroke, and other cardiovascular problems in patients with coronary artery disease.

How quickly does Pendoril work?

Pendoril usually starts to work within 2-4 weeks of starting the medication. However, your doctor may advise you to gradually increase your dose over time to achieve the best results.

What else is Pendoril used for?

Pendoril is also used to treat heart failure and to reduce the risk of developing end-stage kidney disease in patients with diabetes.

Can I drink alcohol while taking Pendoril?

Alcohol can interact with Pendoril and may increase the risk of side effects. You should limit your alcohol intake while taking Pendoril and avoid drinking too much alcohol.

How long should I take Pendoril?

It is important to take Pendoril as prescribed by your doctor. Do not stop taking Pendoril without talking to your doctor first.

Can I buy Pendoril over the counter?

No, Pendoril is a prescription-only medication, so it cannot be bought over the counter.

What should I do if I miss a dose of Pendoril?

If you miss a dose of Pendoril, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take your next dose as usual.

Does Pendoril cause weight gain?

No, Pendoril does not usually cause weight gain. However, if you do experience sudden weight gain, it is important to see your doctor for a check-up.

Does Pendoril lower cholesterol?

Yes, Pendoril can help to lower cholesterol levels and reduce the risk of developing cardiovascular problems.

How long does it take for Pendoril to leave my system?

The amount of time it takes for Pendoril to leave your system depends on the dosage and duration of your treatment. In general, the drug is usually removed from your system within three to four days.

Can I take Pendoril while pregnant?

No, it is not recommended to take Pendoril during pregnancy as the safety of the drug during pregnancy is not yet known.

Is Pendoril safe for children?

Pendoril is not approved for use in children. Talk to your doctor for more information.

Which drugs interact with Pendoril?

Pendoril may interact with other medications, including diuretics, NSAIDs, aspirin, and certain ACE inhibitors. Be sure to discuss any medications you are taking with your doctor before starting Pendoril.

Does Pendoril cause side effects in elderly patients?

Yes, elderly patients may be more at risk of side effects from Pendoril, which can include hypotension, dizziness, and electrolyte imbalances. Talk to your doctor about any concerns you have before starting Pendoril.

Can Pendoril affect kidney function?

Yes, Pendoril can affect kidney function and may increase the risk of developing kidney problems. It is important to monitor your kidney function closely while on Pendoril.

Can Pendoril cause depression?

There is not enough evidence to suggest that Pendoril can cause depression. However, if you experience any signs of depression while taking Pendoril, it is important to seek medical advice.

Is Pendoril safe for long-term use in people with diabetes?

Yes, Pendoril has been found to be safe for long-term use in people with diabetes. It may help to reduce the risk of end-stage kidney disease.

Can I take Pendoril with other hypertension medications?

Yes, Pendoril may be taken with other medications used to treat high blood pressure. It is important to always consult with your doctor before taking any new medications.

What should I do if I experience a severe allergic reaction to Pendoril?

It is important to seek medical attention immediately if you experience a severe allergic reaction to Pendoril, as it can be life-threatening. Signs of a severe allergic reaction can include hives, difficulty breathing, and swelling of the face, tongue, or throat.

Can I take Pendoril if I have a history of angioedema?

No, Pendoril should not be taken if you have a history of angioedema, as it could trigger an allergic reaction. Talk to your doctor about alternative treatment options for your condition.

What should I do if I feel dizzy after taking Pendoril?

It is important to contact your doctor immediately if you are experiencing dizziness after taking Pendoril, as this can be a sign of low blood pressure. The dose may need to be adjusted, or you may need additional medication.

Are there any risks of taking Pendoril if I have kidney disease?

Yes, it is important to discuss your kidney function with your doctor before taking Pendoril, as it may increase the risk of kidney problems in patients with pre-existing kidney disease.

Where can I find more information about Pendoril?

Your doctor or pharmacist should be able to provide you with more information about Pendoril. You can also find more information online and in patient information leaflets.

Is it safe to take Pendoril with ibuprofen?

Yes, Pendoril can be safely taken with ibuprofen. However, it is always best to consult your doctor or pharmacist to make sure the medications are compatible.

Can Pendoril cause tinnitus?

There is not enough evidence to suggest that Pendoril can cause tinnitus. However, if you experience any ringing in your ears while taking Pendoril, it is important to seek medical advice.

Can I buy Pendoril online?

No, Pendoril is a prescription-only medication, so it cannot be bought online without a valid prescription.

Can Pendoril cause liver damage?

Although rare, there have been cases where patients taking Pendoril have experienced liver damage. It is important to contact your doctor immediately if you experience any signs of liver damage, such as yellowing of the skin or eyes, dark urine, or abdominal pain.

Does Pendoril reduce the risk of stroke?

Yes, Pendoril can reduce your risk of stroke, particularly in patients with coronary artery disease.

What are the signs of an overdose of Pendoril?

Signs of an overdose of Pendoril include extreme drowsiness, confusion, rapid heartbeat, and difficulty breathing. If you suspect an overdose, seek medical attention immediately.

Can I take Pendoril with aspirin?

Yes, you can take Pendoril with aspirin, but you should always check with your doctor before taking any new medications.

Does Pendoril cause sleepiness?

Yes, Pendoril can cause drowsiness, so it is important to avoid engaging in activities that require alertness, such as driving, while taking this medication.

Can Pendoril cause dizziness when you stand up?

Yes, Pendoril can cause some patients to feel dizzy when they stand up suddenly, due to a drop in blood pressure. It is important to stand up slowly from a sitting or lying position to reduce the risk of dizziness.

Does Pendoril cause dry mouth?

Yes, dry mouth is a common side effect of Pendoril, and it can be managed by drinking plenty of water and chewing sugar-free gum.

Can Pendoril be used to treat high cholesterol?

Yes, Pendoril can be used to lower cholesterol levels and reduce the risk of cardiovascular problems.

Can Pendoril cause constipation?

Yes, constipation is a possible side effect of taking Pendoril. If constipation does occur, it can usually be managed by drinking plenty of fluids and eating a high-fiber diet.

Can I take Pendoril with a diuretic?

Yes, you can take Pendoril with a diuretic, but it is important to consult your doctor before taking any new medications.

Can Pendoril cause insomnia?

Yes, insomnia is a possible side effect of Pendoril. If you experience insomnia while taking Pendoril, it is important to talk to your doctor about your treatment options.

Can I cut a Pendoril tablet in half?

No, you should not cut Pendoril tablets as it may lead to an inaccurate dose. If you have difficulty swallowing pills, speak to your doctor or pharmacist about alternative forms of medication.