Paritol
Paritol Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Paritol is a brand name. Its generic name is Paricalcitol.
Paritol
Paritol is a medication used to help balance calcium and phosphorus levels in the blood. It is commonly prescribed to treat complications that arise from chronic kidney disease, such as hyperphosphatemia, secondary hyperparathyroidism, and vitamin D deficiency. Paritol works by activating vitamin D receptors, which stimulate the production of proteins that cause phosphorus and calcium to be removed from the bloodstream and deposited into the bones.
Uses of Paritol
Paritol is used to treat complications of chronic kidney disease, such as elevated levels of phosphorus in the blood (hyperphosphatemia), high calcium levels in the blood (hypercalcemia), and low levels of vitamin D (vitamin D deficiency). Paritol can also help to lower the activity of the body’s parathyroid hormone (PTH), which helps to regulate the balance of calcium and phosphorus in the body.
Mechanism of Action
Paritol works by activating vitamin D receptors, which stimulates the production of proteins that cause calcium and phosphorus to be removed from the bloodstream and deposited into the bones. This helps to regulate the balance of calcium and phosphorus in the body and reduce the level of active parathyroid hormone (PTH).
How Long Does it Take to Work?
The effects of Paritol are usually seen within the first few days of treatment. It may take several weeks for the full effects to be noticed.
Absorption
Paritol is rapidly and almost completely absorbed following oral administration.
Route of Elimination
Paritol is eliminated mainly through the kidneys and is not metabolized in the body.
Dosage
The usual starting dose of Paritol is 0.04-0.06 mcg/kg/day. The individual’s condition should be closely monitored and the dosage adjusted to achieve the desired effect. It is important to take Paritol exactly as prescribed by the physician and not to alter the dosage in any way.
Administration
Paritol should be taken orally, ideally once daily or as directed by the physician. The tablet should be taken with or without food. Paritol should not be split, crushed or chewed.
Side-Effect
Common side effects of Paritol include upset stomach, vomiting, diarrhea, constipation, headaches, dizziness and rash. Less common side effects include fluid retention, difficulty breathing, chest pain, and muscle/ joint pain.
Toxicity
Paritol is generally well tolerated and has a low risk of toxicity. Mild side effects may occur but usually go away with continued use of the medication.
Precaution
Patients with kidney disease, liver disease, and certain allergies should be monitored closely while using Paritol, as it can cause an allergic reaction in some people. Additionally, patients with low levels of calcium in their blood or those taking other drugs that can interact with Paritol should also be monitored closely. It is important to tell the doctor about all other medications you are taking so that potential interactions can be avoided.
Interaction
Paritol may interact with certain other medications, such as diuretics, non-steroidal anti-inflammatory drugs, and certain antibiotics. Additionally, it may interact with certain supplements such as calcium and vitamin D. It is important to tell the doctor about all other medications and supplements you are taking so that potential interactions can be avoided.
Disease Interactions
Paritol may interact with diseases such as kidney and liver disease, as well as certain allergies, so it is important to tell the doctor if you are suffering from any of these diseases so that potential interactions can be avoided.
Drug Interactions
Paritol may interact with other drugs such as diuretics, non-steroidal anti-inflammatory drugs, and certain antibiotics. It is important to tell the doctor all other medications you are taking, so that potential interactions can be avoided.
Food Interactions
Paritol does not interact with food. It is usually taken with or without food.
Pregnancy Use
- Paritol is not recommended for use in pregnant women unless the potential benefit to the mother outweighs the potential risk to the fetus.
- It is important to tell the doctor if you are pregnant or planning to become pregnant before taking Paritol.
Lactation Use
Paritol is not recommended for use in breastfeeding women due to the potential risk to the baby. It is important to tell the doctor if you are breastfeeding or plan to breastfeed before taking Paritol.
Acute Overdose
An overdose of Paritol may cause symptoms such as nausea, vomiting, and headache. It is important to seek immediate medical attention if you or someone you know has taken an overdose of Paritol.
Contraindication
Paritol should not be used to treat patients with primary hyperparathyroidism. It should also not be used in patients who are allergic to Paritol or any of its ingredients.
Use Direction
Paritol should be taken as prescribed by the doctor. Do not alter the dosage and do not stop taking the medication without consulting the doctor.
Storage Condition
Paritol should be stored at room temperature, away from light and moisture. Keep out of reach of children and pets.
Volume of Distribution
The volume of distribution for Paritol is unknown.
Half Life
The half-life of Paritol is approximately one hour.
Clearance
The clearance of Paritol is approximately 20L/h.
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