Parflox

Parflox Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Parflox is a brand name. Its generic name is Sparfloxacin.

Parflox Introduction

Parflox is a synthetic quinolone fluoropyrimidine antibiotic drug used to treat infections caused by bacteria. It is used to treat respiratory and urinary tract infections, skin and soft tissue infections, sexually transmitted diseases and ear infections. It is also used to prevent infection prior to surgery.

Parflox Uses and Mechanism of Action

Parflox works by inhibiting the bacterial enzyme DNA gyrase, which is responsible for the synthesis and repair of bacterial DNA and important to the growth of bacteria. DNA gyrase is an integral part of the DNA replication process and is also responsible for its supercoiling. Inhibition of this enzyme leads to an inhibition of bacterial growth and proliferation of bacterial cells.

How Long Does it Take to Work?

The effects of Parflox can be seen within a day of starting the treatment. Most bacterial infections will start to show signs of improvement within 24 to 48 hours of starting the medication although in some cases, it may take up to one week for the infection to clear completely.

Parflox Absorption, Route of Elimination, and Volume of Distribution

Parflox is rapidly and completely absorbed after oral administration, and its bioavailability is almost 100%. It is rapidly metabolized and eliminated in the urine where more than 90% of a given dose is excreted within 24 hours.

The apparent volume of distribution of Parflox is 7.8–14.0 liters and the plasma clearance is 8–13 liters/hr.

Parflox Dosage and Administration

The usual dosage for adults is 200 milligrams (mg) once daily. For children aged between 1 and 12, the dose is 10–20 mg/kg daily, given in two divided doses. For children aged over 12 and adults, the daily dose is 200–400 mg, given in two divided doses.

Parflox should be taken with a full glass of water. It should be taken either 1 hour before or after meals.

Parflox Side Effects, Toxicity, and Precautions

The most common side effects of Parflox include vomiting, nausea, stomach pain, headache, dizziness and rash. Rare but serious side effects include allergic reactions and tendon problems.

Parflox is generally safe when taken as directed. However, it should be used with caution in pregnant or nursing women, as it can harm a fetus or infant.

Parflox is toxic to the kidneys and should be used with caution in patients with kidney damage.

Parflox Interactions

People taking Parflox should avoid taking antacids, anticonvulsants, iron supplements, and mao inhibitors as these medications may interact adversely with Parflox.

Parflox can also interact with other medications, including certain antibiotics, antifungals, diuretics, and cholesterol-lowering drugs.

Parflox Disease Interactions, Drug Interactions, and Food Interactions

People with pre-existing liver or kidney disease should not take Parflox. The amount of Parflox in the body may increase if it is taken with certain other medications that can decrease the amount of potassium or magnesium in the body.

Parflox should not be taken with dairy products or foods fortified with calcium as it can reduce the absorption of the drug. Parflox may also interact with grapefruit juice, alcohol, and caffeine.

Parflox Pregnancy and Lactation Use

Parflox should not be used during pregnancy. It should also not be used while breastfeeding, as it may pass into breast milk and harm a nursing baby.

Parflox Acute Overdose

A single overdose of Parflox is not likely to cause serious harm. However, if multiple doses are taken in one day, it may cause vomiting, dizziness, seizures, confusion, abdominal pain, and a drop in blood pressure.

Parflox Contraindications and Use Direction

Parflox should not be used in patients with a known hypersensitivity to the medication. It should also not be taken in patients with severe kidney impairment.

Parflox may be taken with or without food, but it should not be taken with antacids, anticonvulsants, iron supplements, or mao inhibitors.

Parflox Storage Condition, Half Life, and Clearance

Parflox should be stored at room temperature, away from light and moisture. It has a plasma half-life of 7 to 10 hours and is completely metabolized by the liver and excreted in the urine.

Here you find in details version of Parflox

Some Frequently Asked Questions About Parflox

What is Parflox?

Parflox is a synthetic fluoroquinolone antibiotic used to treat bacterial infections.

How does Parflox work?

Parflox works by interfering with the ability of bacteria to reproduce. It does this by targeting an enzyme called topoisomerase which helps the bacteria replicate DNA.

What kinds of bacterial infections can Parflox treat?

Parflox is used to treat a number of different bacterial infections, including airway infections, skin and soft tissue infections, pneumonia, otitis media, and urinary tract infections.

Is Parflox a safe drug?

Parflox is generally safe when taken as directed. However, due to a risk of serious adverse effects, it should not be used in pregnant or nursing women, or children less than 18 years of age.

What are the side effects of Parflox?

Common side effects of Parflox include nausea, headache, dizziness, lightheadedness, abdominal pain, diarrhea, and rash. In rare cases, more serious side effects such as liver toxicity, tendon rupture, or arrhythmias may occur.

Is Parflox a generic drug?

Parflox is the brand name of a fluoroquinolone antibiotic manufactured by Zydus Cadila. It is not available in generic form.

Is Parflox a prescription drug?

Yes, Parflox is a prescription drug and must be prescribed by a doctor.

Does Parflox need to be taken with food?

No, Parflox does not need to be taken with food. It can be taken with or without food, but should be taken with a full glass of water.

What is the recommended dosage of Parflox?

The recommended dose of Parflox for adults is 200 mg once daily for 7-10 days, depending on the type of infection being treated. Your doctor may adjust the dose depending on your response to treatment.

What if I miss a dose of Parflox?

If you miss a dose of Parflox, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.

Can I take Parflox with other medications?

It is important to tell your doctor about any other medications, supplements, or herbal remedies you are taking, as they may interact with Parflox. Certain medications may increase your risk of side effects or reduce the effectiveness of Parflox.

What should I do if I experience side effects from Parflox?

If you experience any side effects while taking Parflox, contact your doctor immediately. In the event of an allergic reaction, seek emergency medical help.

What should I do if I overdose on Parflox?

If you or someone else has taken an overdose of Parflox, seek emergency medical help immediately. Overdose symptoms may include nausea, vomiting, seizure, confusion, and difficulty breathing.

Should I avoid certain foods or activities while taking Parflox?

You should avoid activities that might put you at risk of a sunburn while taking Parflox, as it can make your skin more sensitive to sunlight. You should also avoid consuming dairy products or calcium supplements within 2 hours of taking Parflox.

Can I drink alcohol while taking Parflox?

It is not recommended to drink alcohol while taking Parflox due to an increased risk of side effects. If you must drink alcohol, it should be done in moderation.

How long does it take for Parflox to work?

It may take up to 48 hours for Parflox to start working, but it should improve your symptoms within several days of starting the medication. Follow your doctor's instructions for taking Parflox.

How should Parflox be stored?

Parflox should be stored at room temperature away from light and moisture. Keep it in the original container it came in and out of reach of children.

Is it safe to use Parflox during pregnancy?

No, it is not recommended to use Parflox during pregnancy due to the risk of serious adverse effects. If you are pregnant or planning to become pregnant, tell your doctor before taking Parflox.

What should I do if I develop allergic symptoms while taking Parflox?

If you experience any signs of an allergic reaction, such as rash, itching, swelling, or difficulty breathing, contact your doctor immediately. Your doctor may advise you to stop taking Parflox and switch to a different antibiotic.

Does Parflox interact with any other drugs?

Yes, Parflox can interact with other drugs, including antacids, nonsteroidal anti-inflammatory drugs, and drugs that contain magnesium, aluminum, or calcium. Your doctor should be aware of all drugs you are taking before prescribing Parflox.

Should I take probiotics while taking Parflox?

It is generally recommended to take probiotics while taking Parflox as it can help restore the balance of bacteria in the gut. Before taking probiotics, it is important to consult your doctor.

Can I take Parflox for travelers' diarrhea?

Yes, Parflox may be used to treat travelers' diarrhea if caused by bacteria. It is important to check with your doctor before taking any medication for travelers' diarrhea.

Does Parflox affect birth control?

Yes, Parflox may reduce the effectiveness of certain types of birth control, including the birth control pill and contraceptive injections. It is important to use a backup form of birth control while taking Parflox.

Does Parflox cause photosensitivity?

Yes, Parflox may increase your sensitivity to sunlight, which can lead to skin reactions. To minimize this risk, it is important to wear protective clothing, use sunscreen, and avoid artificial sources of light such as tanning beds while taking Parflox.

Does Parflox have any drug interactions with antacids?

Yes, Parflox may interact with certain antacids, such as famotidine and cimetidine, which can reduce the absorption and effectiveness of Parflox. It is important to talk to your doctor about any antacids you are taking before starting Parflox.

Is it safe to take Parflox if I have a history of kidney disease?

It is generally not recommended to take Parflox if you have a history of kidney disease. If your doctor prescribes Parflox, your kidney function will need to be monitored closely.

Does Parflox interact with other fluoroquinolones?

Yes, Parflox may interact with other fluoroquinolones, such as ciprofloxacin. It is important to tell your doctor if you are taking any other fluoroquinolones before taking Parflox.

Should I take Parflox if I am breastfeeding?

No, Parflox is not recommended for use in breastfeeding women due to a risk of harm to the baby. If you are a nursing mother, talk to your doctor about alternative treatments.

How long will Parflox stay in my system?

The half-life of Parflox is 6-8 hours, which means it generally takes about 36-48 hours for Parflox to be completely eliminated from the body. However, the actual time can vary depending on individual factors.

Is Parflox safe for use in children?

No, Parflox is not recommended for use in children under 18 years of age due to a risk of serious side effects. Alternative antibiotic treatments should be considered for use in children.

Does Parflox cause gastrointestinal disturbances?

Yes, Parflox may cause gastrointestinal disturbances, such as nausea, vomiting, diarrhea, and abdominal pain. If you experience such symptoms, talk to your doctor about ways to manage them.

Can I take Parflox while taking blood thinners?

No, it is not recommended to take Parflox while taking blood thinners, such as warfarin or coumarin, as there is a risk of increasing the risk of bleeding or bruising. If your doctor prescribes Parflox, your blood clotting should be monitored closely.

Does Parflox cause changes in your sense of taste?

Yes, Parflox may cause changes in your sense of taste. If you experience an altered taste, talk to your doctor about ways to manage it, such as taking a multivitamin or avoiding certain foods.

Can I take Parflox while taking steroids?

No, it is not recommended to take Parflox while taking steroids, as they may interact and increase the risk of side effects. Your doctor can advise you on an alternative treatment plan if necessary.

Can I take Parflox while taking a sulfonamide?

No, it is not recommended to take Parflox while taking a sulfonamide, as they may interact and increase the risk of side effects. Your doctor can advise you on an alternative treatment plan if necessary.

Can I take Parflox while taking probenecid?

No, it is not recommended to take Parflox while taking probenecid, as they may interact and increase the risk of side effects. Your doctor can advise you on an alternative treatment plan if necessary.

Does Parflox interact with any herbal supplements?

Yes, Parflox may interact with some herbal supplements, such as ginseng, St. John’s wort, and kava kava, which can reduce the effectiveness of Parflox. Before taking any herbal supplements, it is important to talk to your doctor.

Is Parflox a good choice for treating infections that are resistant to other antibiotics?

Yes, Parflox is effective in treating infections that are resistant to other antibiotics. However, it is important to discuss any existing resistance to antibiotics with your doctor before taking Parflox.

Does Parflox cause bone or joint pain?

Yes, Parflox may cause joint or bone pain in some patients. If you experience joint or bone pain, talk to your doctor about ways to manage it, such as taking an over-the-counter pain reliever.

Can I take Parflox if I have a history of heart disease?

Yes, Parflox can be taken if you have a history of heart disease. However, your doctor should monitor your heart function closely while taking Parflox.