Paragan
Paragan Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Paragan is a brand name. Its generic name is Indomethacin.
Paragan
Paragan is a non-steroidal anti-inflammatory drug (NSAID) belonging to the class of drugs called Indole Acetic Acid derivatives. It works by blocking the production of prostaglandins, the chemicals that cause inflammation, swelling, and pain which are responsible for symptoms caused by inflammatory diseases such as arthritis, tendinitis, bursitis, and gout. It is also used to alleviate migraine headaches and reduce fevers.
Uses for Paragan
Paragan is used to treat inflammatory diseases, reduce pain, swelling, and stiffness in joints and other structures. It is also used for pain relief in mild to moderate musculoskeletal and joint conditions such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, tendinitis, and bursitis. It is also used for painful muscles and joints, such as caused by psoriatic arthritis, and to reduce fever caused by illnesses such as colds and flu.
Mechanism of Action
Paragan works by blocking the production of prostaglandins – the main chemical responsible for pain, swelling and inflammation. Blocking the production of prostaglandins can relieve inflammation, swelling and pain. By limiting the production of prostaglandins, indomethacin also reduces the inflammation and redness associated with certain conditions.
How Long Does It Take to Work?
The effects of indomethacin can be felt within 1-2 weeks, but it may take up to 6 weeks for the full effects to be seen. As with all medications, it's important to take indomethacin as directed and speak to a healthcare professional if any questions arise.
Absorption
Paragan is moderately absorbed from the gastrointestinal tract with peak concentrations reached 3 to 4 hours after oral administration.
Route of Elimination
Paragan is eliminated primarily by the kidneys via glomerular filtration and tubular secretion. Some is also metabolized in the liver by cytochrome P450 enzymes.
Dosage
The usual dose of indomethacin is 25-50 mg 3-4 times daily. The dose may be increased up to 100 mg 4 times daily, if necessary. It is important to take indomethacin exactly as prescribed by a doctor, and to not exceed the prescribed dose.
Administration
Paragan should be taken orally with food or a full glass of water to reduce side effects and to ensure that it is correctly absorbed. It should not be taken near meals or snacks as the food will reduce the absorption of the medication.
Side Effects
Common side effects include stomach upset, nausea, and vomiting, as well as headache, dizziness, and drowsiness. More serious side effects that require immediate medical attention include bloody stools or black, tarry stools, confusion, rapid heartbeat, or skin rash or itching.
Toxicity
Paragan is generally safe when taken at the recommended dosage. However, taking too much of this medication can cause serious side effects including kidney failure, abdominal pain, nausea, and vomiting. If any of these more serious side effects occur, contact a doctor immediately.
Precautions
Patients should inform their healthcare provider if they have any other medical conditions, are pregnant, breastfeeding, taking any medications or supplements, or have any allergies. Patients should also avoid activities that require alertness such as driving or operating machinery until the medication’s effects are known. Patients should not take indomethacin if bleeding or any other bleeding disorders are present.
Interactions
Paragan can interact with several other medications, including aspirin, NSAIDs, blood thinners, diuretics, lithium, and steroids. It is important to tell a healthcare provider about all medications being taken before starting indomethacin in order to avoid any drug interactions.
Disease Interactions
Patients with congestive heart failure or kidney or liver disease should not take indomethacin, as these conditions can increase the risk of certain side effects.
Drug Interactions
Paragan can interact negatively with certain drugs, including aspirin, NSAIDs, blood thinners, diuretics, lithium, and steroids. It is important to inform a healthcare provider about all medications being taken before starting indomethacin.
Food Interactions
Paragan should not be taken near meals or snacks as the food will reduce the absorption of the medication.
Pregnancy Use
Paragan should not be used by pregnant women, as it may cause harm to the unborn baby. Women who are breastfeeding should also not take indomethacin, as it can pass into breast milk.
Lactation Use
Paragan passes into breast milk and should not be taken by breastfeeding mothers.
Acute Overdose
Symptoms of acute indomethacin overdose may include nausea, vomiting, abdominal pain, dizziness, confusion, drowsiness, coma, and possibly seizures, coma, and death. If any of these side effects occur, seek medical attention immediately.
Contraindication
Paragan should not be taken by anyone with active gastrointestinal bleeding, history of bleeding disorders, or any other medical conditions that could be aggravated by taking indomethacin. It is also not recommended for use by people who are allergic to any of the ingredients in the medication.
Use Direction
It is important to take indomethacin exactly as prescribed. Do not use more or less than directed and never take it for a longer period of time than prescribed. The usual dose is 25-50 mg 3-4 times daily and may be increased up to 100 mg 4 times daily, if necessary.
Storage Condition
Store indomethacin at room temperature, away from direct sunlight, heat, and moisture. Do not store in the bathroom. Keep this medication away from children and pets.
Volume of Distribution
The volume of distribution of indomethacin is 0.17 L/kg.
Half-Life
The half-life of indomethacin is 2-4 hours.
Clearance
The clearance of indomethacin is 0.24 L/h/kg.
Here you find in details version of Paragan
Some Frequently Asked Questions About Paragan
What is Paragan?
Paragan is a nonsteroidal anti-inflammatory drug (NSAID) used to treat various forms of arthritis, as well as gout and pain caused by inflammation. It is a generic medication and is available over-the-counter as capsules or tablets.
What is Paragan used for?
Paragan is used to reduce pain, inflammation, and stiffness in people with gout, osteoarthritis, and pain caused by rheumatic conditions such as bursitis, tendinitis, and ankylosing spondylitis.
How does Paragan work?
Paragan blocks the production of prostaglandins, which are substances in the body that can contribute to inflammation in certain conditions. By blocking the production of prostaglandins, Paragan can reduce inflammation and pain.
How should I take Paragan?
Follow your doctor’s instructions for taking Paragan. It is usually taken every 8 hours, with or without food. Swallow the capsules or tablets whole with a glass of water. Do not split, chew, or crush the capsules or tablets.
What are the side effects of Paragan?
Common side effects of Paragan include nausea, stomach pain, diarrhea, heartburn, headache, dizziness, drowsiness, and rash. Some people may experience more serious side effects including low blood pressure, kidney or liver damage, and bleeding. Tell your doctor if you experience any side effects.
What should I avoid while taking Paragan?
Avoid drinking alcohol while taking Paragan as it may increase the risk of liver or kidney damage. Avoid taking aspirin or other NSAIDs while taking Paragan, as it may increase the risk of stomach ulcers or bleeding. Tell your doctor if you have any questions about what to avoid while taking Paragan.
Is Paragan safe to take while pregnant?
It is not known if Paragan is safe for use during pregnancy. Talk to your doctor if you are pregnant or planning to become pregnant before taking Paragan. It is not recommended for use during the last 3 months of pregnancy.
Can I take Paragan if I'm breastfeeding?
It is not known if Paragan passes into breast milk. Talk to your doctor before taking Paragan if you are breastfeeding. Alternative forms of relief should be considered if you are nursing.
When should I not take Paragan?
Do not take Paragan if you have a history of stomach ulcers or bleeding; have had an allergic reaction to Paragan or other NSAIDs; or have asthma, severe kidney or liver function impairment, or heart failure. Talk to your doctor before taking Paragan.
Should I tell my doctor about any medications I'm taking when prescribed Paragan?
Yes. Tell your doctor about all of the medications you are taking, including any over-the-counter medications, vitamins, or herbal supplements, as these could affect the way Paragan works. Your doctor may suggest alternative forms of relief for you or adjust your dosage to accommodate your other medications.
What should I do if I miss a dose of Paragan?
If you miss a dose of Paragan, take it as soon as you remember, unless it is almost time for your next dose. Do not take two doses of Paragan at the same time. If you take more than the prescribed dose, contact your doctor or poison control center for advice.
How long does it take for the effects of Paragan to start working?
The effects of Paragan usually start working within 1 to 2 days after starting treatment. However, it can take several days or longer before the full effects can be felt. Talk to your doctor if you have any questions about the effects of Paragan or how long before it will start working.
Can I take other medications while taking Paragan?
Some medications can interact with Paragan. Tell your doctor about all of the medications you are taking, including any over-the-counter medications, vitamins, or herbal supplements, as these can affect how Paragan works. Your doctor may suggest alternative forms of relief for you or adjust your dosage to accommodate your other medications.
What other drugs interact with Paragan?
Some medications can interact with Paragan. These medications include aspirin and other NSAIDs, diuretics, lithium, methotrexate, probenecid, and warfarin. Talk to your doctor about all of the medications you are taking before taking Paragan.
What would happen if I overdose on Paragan?
If you think you may have overdosed on Paragan, contact an emergency room or poison control center immediately. Symptoms of an Paragan overdose can include nausea, vomiting, stomach pain, drowsiness, and dizziness.
Is it safe to take Paragan for a long period of time?
Paragan is generally well-tolerated, but it can cause stomach ulcers and bleeding after long-term use. Talk to your doctor if you are considering taking Paragan for a long period of time or if you experience any side effects while taking it.
Will I experience withdrawal symptoms if I stop taking Paragan?
It is not common for people to experience withdrawal symptoms when stopping Paragan. However, if you have been taking it for a long period of time, you should talk to your doctor before stopping as they can advise you on how to safely stop taking it.
What are some possible alternatives to Paragan?
There are many alternative medications to Paragan for treating pain, inflammation, and stiffness in people with gout, osteoarthritis, and rheumatic conditions. Examples of alternative medications include ibuprofen, naproxen, and celecoxib. Talk to your doctor about alternatives to Paragan.
Can I take Paragan for migraines or headaches?
No, Paragan is not recommended for use in treating migraines or headaches. Talk to your doctor about other medications that can be taken for migraines or headaches.
What is the difference between Paragan and other NSAIDs?
Paragan is a nonsteroidal anti-inflammatory drug (NSAID) used to treat various forms of arthritis, as well as gout and pain caused by inflammation. Other NSAIDs work in a similar way but have different active ingredients. Talk to your doctor about which medication may be best for your symptoms.
Should I take Paragan on an empty stomach?
Paragan can be taken with or without food. It is important that you follow your doctor’s instructions for taking Paragan. Talk to your doctor if you have any questions about whether to take Paragan on an empty stomach.
What should I do if Paragan isn't working for my symptoms?
If Paragan isn't working for your symptoms, talk to your doctor. They may suggest alternative forms of relief for you or adjust your dosage. Do not increase your dosage of Paragan without talking to your doctor first.
Can I take Paragan if I'm allergic to aspirin or other NSAIDs?
No, Paragan should not be taken if you are allergic to aspirin or other NSAIDs. Talk to your doctor if you have any allergies that may affect your ability to take Paragan.
Does Paragan have any serious interactions with other medications or supplements?
Yes, some medications can interact with Paragan. These medications include aspirin and other NSAIDs, diuretics, lithium, methotrexate, probenecid, and warfarin. Talk to your doctor about all of the medications you are taking, including any supplements, before taking Paragan.
What should I do if I think I am experiencing side effects from Paragan?
If you are experiencing any side effects from Paragan, talk to your doctor right away. Do not stop taking the medication unless advised to do so by your doctor.
What is the maximum daily dose of Paragan I can take?
The maximum daily dose of Paragan depends on your individual medical history and the condition being treated. Talk to your doctor about the maximum daily dose of Paragan that is right for you.
Is Paragan available over-the-counter?
Paragan is available over-the-counter in the form of capsules or tablets. However, you should talk to your doctor before taking Paragan, as they can advise you on the correct dosage and any other medications or supplements you are taking.
How long does Paragan stay in my system?
Paragan has a half-life of approximately 4 to 7 hours, meaning that is the amount of time it takes for the drug to be reduced by half in the bloodstream. However, it can take several days or longer for the drug to be completely eliminated from your system.
Is Paragan safe for children to take?
No, Paragan is not recommended for use in children. Talk to your doctor about alternative forms of relief that may be safe for your child.
Should I take Paragan with food?
Paragan can be taken with or without food. It is important to follow your doctor's instructions for taking Paragan. Talk to your doctor about whether you should take Paragan with food.
Can I take Paragan if I have high blood pressure?
Yes, you can take Paragan if you have high blood pressure. However, it is important that you talk to your doctor about any conditions you have before taking it, as they can advise you on the correct dosage and any other medications or supplements you are taking.
Can I take Paragan if I have kidney or liver problems?
If you have kidney or liver problems, talk to your doctor before taking Paragan. Your doctor may suggest alternative forms of relief or adjust your dosage to accommodate your kidney or liver problems.
Does Paragan cause drowsiness?
Yes, drowsiness can be a side effect of taking Paragan. If you experience drowsiness while taking Paragan, do not drive or operate heavy machinery until these effects have worn off.
Could I become dependent on Paragan?
No, you cannot become physically dependent on Paragan. However, you should talk to your doctor before stopping use of Paragan, as they can advise you on how to safely stop taking it.
Is it safe to take Paragan with other pain relievers or anti-inflammatories?
No, it is not recommended to take Paragan with other pain relievers or anti-inflammatories. Talk to your doctor before taking any other medication or supplement while taking Paragan.
Can I drink alcohol while taking Paragan?
No, it is not recommended to drink alcohol while taking Paragan. Drinking alcohol while taking Paragan may increase the risk of kidney or liver damage.