Pacet

Pacet Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Pacet is a brand name. Its generic name is Amiodarone.

Introduction

Pacet is an antiarrhythmic medicine which is used to treat abnormally rapid heartbeats (arrhythmias). It is sold by the trade name Cordarone. It is used to treat life-threatening arrhythmias, and has been found to be useful in helping to keep patients’ heart rhythms back in a normal rhythm.

Uses For

Pacet is used to treat life-threatening arrhythmias, including ventricular tachycardia, ventricular fibrillation, and atrial fibrillation (an abnormal form of rapid heartbeat). It can also be used to treat atrial flutter, and is useful in preventing or lessening recurrent arrhythmias.

Mechanism of Action

Pacet works by slowing down the nerve signals that control the heart rate. This helps to slow the arrhythmia, which helps to increase the heart’s oxygen supply, and helps to restore the heart’s normal rhythm. Pacet also has an anti-inflammatory effect which may help to reduce the damage to the heart during an arrhythmia episode.

How Long Does it Take to Work?

Pacet generally takes effect within one to two weeks of starting the treatment. The best results, however, come after continued use for at least three to six months.

Absorption

Pacet is taken orally and is absorbed quickly and completely into the bloodstream.

Route of Elimination

Pacet is eliminated primarily by the liver in the form of inactive metabolites. A small portion of the drug is also eliminated through the kidneys and bile.

Dosage

For adult patients, the usual oral dose for arrhythmias is 400mg to 1600mg daily, given in divided doses three to four times per day. Dosage modifications may be necessary for patients who have liver or kidney disease, or for those taking other medications.

Administration

Pacet should be taken with or without food at least one hour before a meal. It should be taken as prescribed by your doctor or pharmacist.

Side Effects

The most common side effects from amiodarone include nausea, vomiting, dizziness, lightheadedness, headache, diarrhea, loss of appetite, and skin rash. Some rare but serious side effects may include liver toxicity, lung toxicity, vision changes, and thyroid problems.

Toxicity

Pacet can be potentially toxic if taken in overdose. Symptoms of overdose may include vomiting, confusion, difficulty breathing, light sensitivity, and loss of consciousness.

Precautions

It is important to tell your doctor or pharmacist about all prescription, non-prescription, illegal, recreational, herbal, nutritional, or dietary drugs you are taking. Pacet should be used with caution in patients with low blood pressure, impaired liver or kidney function, or certain heart conditions.

Interactions

Pacet may interact with some other medications, including blood pressure medicines, aminoglycosides, digoxin and quinidine. Certain drugs should be avoided while taking amiodarone, as they may increase the risk of side effects. This includes drugs such as wasabi or horseradish.

Disease Interactions

Patients with certain heart conditions, such as heart block, may be at an increased risk of developing arrhythmia while taking amiodarone. Therefore, such patients should be carefully monitored for any changes in their condition. Pacet should also be used with caution in patients with a history of liver or kidney disease.

Drug Interactions

Pacet may interact with certain drugs, such as aminoglycosides, calcium channel blockers, digoxin, and quinidine. Consult your doctor or pharmacist before starting or stopping any medication or supplements while taking amiodarone.

Food Interactions

Pacet should be taken at least one hour before or after meals, to minimize the risk of interaction with certain foods. Foods that contain high amounts of vitamin K or omega-3 fatty acids may increase the risk of side effects when taken with amiodarone.

Pregnancy Use

Pacet has not been adequately studied in pregnant women. Therefore, it should be used during pregnancy only if the potential benefit justifies the potential risk to the unborn baby. Women should also be advised to not breastfeed while taking amiodarone.

Lactation Use

Pacet has not been adequately studied in breastfeeding women. Because of the potential risk to the infant, women who are breastfeeding should not take amiodarone.

Acute Overdose

Symptoms of an acute overdose may include excessive drowsiness, confusion, lightheadedness, slow heart rate, and muscle weakness. Contact your doctor or healthcare provider immediately if you experience any of these symptoms.

Contraindication

Pacet is contraindicated in patients with certain medical conditions, such as low blood pressure (hypotension), second or third degree heart block, or a history of slow heart rate (bradycardia). It is also contraindicated in patients taking drugs known to cause severe or life-threatening arrhythmias.

Use Direction

Pacet should be taken as prescribed by your doctor or pharmacist. It should also be taken at least one hour before or after meals, to minimize the risk of interactions with certain foods.

Storage Condition

Pacet should be stored at room temperature, away from direct light and moisture. It should be kept in a tight container. Keep out of the reach of children.

Volume of Distribution

Approximately 8-40 liters (32-160 ounces) of amiodarone is distributed throughout the body following a single oral dose.

Half Life

The elimination half-life of amiodarone typically ranges from 10-60 hours, meaning that up to 60 hours may be needed for the drug to be completely eliminated from the body.

Clearance

Pacet is eliminated primarily by the liver. It is also eliminated through the kidneys and bile.

Here you find in details version of Pacet

Some Frequently Asked Questions About Pacet

What is Pacet?

Pacet is an antiarrhythmic medication used to treat irregular heart rhythms, also known as arrhythmias. It is sold under the brand name Cordarone, and is sometimes referred to by the generic name amiodarone hydrochloride.

How does Pacet work?

Pacet works by blocking the action of certain electrical pathways in the heart. By doing so, it helps to keep the heart in a regular, steady rhythm. It also helps to slow down the heart rate if it is beating too fast.

What are the side effects of Pacet?

Common side effects of Pacet include nausea, vomiting, diarrhea, constipation, dizziness, headache, blurred vision, and a metallic taste in the mouth. More serious side effects may include liver or lung damage, low white or red blood cell counts, rash, extreme fatigue, cardiac arrhythmia, and heart block. In rare cases, Pacet may cause an eye disorder called uveitis.

Can Pacet cause weight gain?

Yes, Pacet can cause weight gain. In addition, Pacet can cause an increase in appetite, which can contribute to weight gain as well.

What should I do if I experience any side effects while taking Pacet?

If you experience any side effects while taking Pacet, you should contact your doctor immediately. Be sure to mention any new or worsening side effects.

How long does it take for Pacet to start working?

Pacet usually takes several weeks to start working. The full effects of the medication may not be seen for up to 6 months. Be sure to take the medication exactly as prescribed for the best results.

Can Pacet be taken with other medications?

Yes, Pacet can be taken with other medications, but it is important to tell your doctor if you take any medications regularly. Certain medications may interact with Pacet and cause serious side effects.

Does Pacet cause birth defects?

Yes, Pacet has been linked to an increased risk of birth defects, including heart defects, when taken during the first three months of pregnancy. Women who are pregnant or planning to become pregnant should talk to their doctor before starting Pacet.

What should I do if I miss a dose of Pacet?

If you miss a dose of Pacet, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take your next dose as scheduled. Do not take a double dose of Pacet.

Can I take Pacet while breastfeeding?

No, it is not recommended to take Pacet while breastfeeding. Some of the medication can pass into breast milk and it may cause serious side effects in a nursing infant.

Does Pacet interact with alcohol?

Yes, it is not recommended to drink alcohol while taking Pacet. Alcohol can interact with the medication and cause an increased risk of side effects, including dizziness and drowsiness.

How should Pacet be stored?

Pacet should be stored at room temperature. Keep the medication in a dry place, away from direct heat and sunlight. Do not store Pacet in the bathroom.

Can I take Pacet if I have a history of heart failure?

Yes, Pacet can be used to treat arrhythmias in patients with a history of heart failure. However, it is important to tell your doctor about any history of heart failure before starting the medication.

What should I do if my symptoms don't improve while taking Pacet?

If your symptoms don't improve while taking Pacet, contact your doctor right away. Your doctor may need to adjust your dose or switch your medication.

Can Pacet be used to treat ventricular tachycardia?

Yes, Pacet is often used to treat ventricular tachycardia, a type of arrhythmia. It can also be used to treat atrial fibrillation and atrial flutter.

Can I take over-the-counter medications while taking Pacet?

Yes, you can take over-the-counter medications while taking Pacet, but always check with your pharmacist or doctor first. Certain medications may interact with Pacet and cause serious side effects.

Can Pacet cause permanent damage to the heart?

No, Pacet does not typically cause permanent damage to the heart. However, long-term use of the medication may cause other side effects, including lung and liver damage.

Does Pacet interact with other herbs or supplements?

Yes, Pacet can interact with certain herbs and supplements. Be sure to tell your doctor if you take any vitamins, minerals, or herbal supplements, as some of these can interfere with the medication.

Can Pacet be used to treat atrial fibrillation?

Yes, Pacet is often used to treat atrial fibrillation, as well as other types of arrhythmias. It can also be used to treat atrial flutter.

What other conditions can Pacet be used to treat?

In addition to treating arrhythmias, Pacet is sometimes used to treat ventricular tachycardia, bradycardia, and atrial fibrillation. It may also be used to treat certain types of chest pain.

When should I take Pacet?

You should take Pacet exactly as prescribed by your doctor. In general, it is taken once a day, either with or without food. You should also drink plenty of fluids while taking the medication.

Can I stop taking Pacet if my symptoms improve?

No, you should never stop taking Pacet without first talking to your doctor. Abruptly discontinuing the medication may cause your arrhythmias to worsen.

Can Pacet make my skin sensitive to sunlight?

Yes, Pacet can make your skin more sensitive to sunlight. Be sure to wear sun-protective clothing and use sunscreen when going outdoors, even for short periods of time.

Can I take Pacet if I have low blood pressure?

Yes, Pacet can be used to treat arrhythmias in patients with low blood pressure. However, you should tell your doctor about any history of low blood pressure before starting the medication.

Can Pacet be used in children?

Yes, Pacet can be used to treat certain arrhythmias in children. However, the dosage is based on the child's weight and age, so it is important to speak to your doctor before starting any medication for a child.

Is Pacet habit forming?

No, Pacet is not habit forming. However, it is important to take the medication as prescribed to ensure the best results.

Does Pacet cause hair loss?

Yes, hair loss is a possible side effect of Pacet. If you notice hair loss or changes in your hair texture or color while taking Pacet, make sure to tell your doctor.

Does Pacet increase the risk of blood clots?

Yes, Pacet may increase the risk of abnormal blood clots forming in the body. If you experience any unusual pain or swelling while taking Pacet, contact your doctor right away.

Can I take Pacet if I have an allergy to iodine?

No, it is not advised to take Pacet if you are allergic to iodine. Speak to your doctor before starting any new medication, as some medications contain iodine or other substances that can cause an allergic reaction.

Does Pacet cause liver damage?

Yes, long-term use of Pacet may cause liver damage. Be sure to tell your doctor if you experience any signs of liver problems, such as dark urine, jaundice, or appetite loss.

Can Pacet be used to treat atrial flutter?

Yes, Pacet is often used to treat atrial flutter, a type of arrhythmia. It is also used to treat ventricular tachycardia and atrial fibrillation.

How long does it take for Pacet to be effective?

Pacet usually takes several weeks to start working. The full effects of the medication may not be seen for up to 6 months. Be sure to take the medication exactly as prescribed for the best results.

What other drugs interact with Pacet?

There are a number of drugs that can interact with Pacet, including certain antibiotics, antifungals, and HIV medications. Be sure to tell your doctor about any medications you are taking before starting Pacet.

Can I take Pacet if I have a history of thyroid disease?

Yes, Pacet can be used to treat arrhythmias in patients with a history of thyroid disease. However, you should tell your doctor if you have a history of thyroid disorder before starting Pacet.

What should I do if I vomit after taking Pacet?

If you vomit shortly after taking Pacet, contact your doctor as soon as possible. You may need to take a replacement dose of the medication.

Can I take Pacet if I am pregnant?

No, it is not recommended to take Pacet while pregnant. Pacet has been linked to an increased risk of birth defects, including heart defects, when taken during the first three months of pregnancy.

Can Pacet cause dizziness?

Yes, dizziness is a common side effect of Pacet. Be sure to take the medication with food and drink plenty of fluids to lessen the risk of dizziness.

Can Pacet be used to treat bradycardia?

Yes, Pacet is often used to treat bradycardia, a type of arrhythmia. It can also be used to treat ventricular tachycardia and atrial fibrillation.