Oxapro
Oxapro Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Oxapro is a brand name. Its generic name is Oxaprozin.
Introduction
Oxapro is a non-steroidal anti-inflammatory drug (NSAID) belonging to the oxicam class. It is used to treat mild to moderate pain, fever, and inflammation, and is approved for up to 21 days of use.
Uses for
Oxapro is primarily used to treat pain and inflammation caused by certain conditions, such as arthritis and other musculoskeletal disorders. It may also be used to reduce fever associated with these conditions.
Mechanism of Action
Oxapro works by blocking the effect of certain hormones that cause inflammation, pain, and fever in the body. It does this by inhibiting the activity of the enzymes which normally catalyze the breakdown of the hormone prostaglandin. This subsequently reduces the effects of inflammation, pain, and fever.
How long does it take to work?
Oxapro usually starts to take effect within a few hours of taking the first dose. The full effects of the drug may take up to a few days to be fully realized.
Absorption
Oxapro is rapidly absorbed after oral administration. The peak concentration is usually observed within 1–2 hours after administration.
Route of Elimination
Oxapro is primarily eliminated unchanged in the urine.
Dosage
The recommended dose of Oxapro is 600mg (two 300mg tablets taken together) once or twice a day, with or without food. The same dose should be taken on a regular schedule (every 12 hours for twice daily dosing or every 24 hours for once daily dosing). The dose should not exceed 600mg (two 300mg tablets) in any 24 hour period.
Administration
Oxapro tablets should be swallowed whole, with a full glass of water. It can be taken with or without food, but should be taken at the same time each day.
Side Effect
Oxapro may cause side effects such as nausea, indigestion, headache, dizziness, and skin rashes. It may also cause constipation, diarrhea, or changes in vision. Long-term use of Oxapro may increase the risk of kidney, liver, and cardiovascular side effects. Therefore, it is important to discuss any potential side effects with your doctor before taking the drug.
Toxicity
Oxapro is generally safe and well-tolerated when used at recommended doses, but it may become toxic when taken in overdoses. In cases of overdose, it is important to seek medical attention immediately in order to reverse any potentially serious side effects.
Precautions
Before taking Oxapro, it is important to tell your doctor about any kind of allergies you may have, as well as any existing medical conditions, such as liver or kidney disease, heart disease, or high blood pressure. It is also important to avoid taking Oxapro in combination with other NSAIDs, as this may increase the risk of side effects.
Interaction
Care should be taken when using Oxapro with other medications, as it may interact with some medications, including anticoagulants, antidepressants, diuretics, oral hypoglycemic drugs, and lithium. It is important to tell your doctor about all medications you are taking before starting on Oxapro.
Disease Interaction
Certain diseases may affect the use of Oxapro. It should be used with caution if you have a history of asthma, diabetes, congestive heart failure, or renal failure. It is also important to be aware of any reactions that may occur due to a history of stomach or intestinal problems.
Drug Interaction
Oxapro should not be taken with aspirin or with other NSAIDs, as this may increase the risk of side effects and potentially increase the risk of gastrointestinal bleeding. It may also interact with certain anticoagulants, diuretics, and methotrexate. It is important to discuss any potential drug interactions with your doctor before starting on this medication.
Food Interactions
Alcohol should be consumed in moderation when taking Oxapro, as this may increase the risk of side effects. Grapefruit juice may also interact with the medication, increasing the risk of side effects.
Pregnancy Use
Oxapro should not be taken during pregnancy, as this may increase the risk of harm to the unborn baby. It is best to discuss the risk with your doctor before taking the medication.
Lactation Use
Oxapro may pass into breast milk and may cause harm to the baby. Therefore, it is important to discuss with your doctor whether or not to take the medication while breastfeeding.
Acute Overdose
In cases of acute overdose, it is important to seek medical attention immediately in order to reverse any potentially serious side effects.
Contraindication
Oxapro should not be taken by people who are allergic to aspirin or other NSAIDs, those who have had an allergic reaction to the drug in the past, or those who have had kidney or liver problems.
Use Direction
Oxapro should be taken as directed by your doctor. The recommended dose is 600mg (two 300mg tablets taken together) once or twice a day, with or without food. The same dose should be taken on a regular schedule (every 12 hours for twice daily dosing or every 24 hours for once daily dosing). The dose should not exceed 600mg (two 300mg tablets) in any 24 hour period.
Storage Condition
Oxapro tablets should be stored at room temperature and away from light and moisture.
Volume of Distribution
The volume of distribution of Oxapro is approximately 500 L/kg.
Half Life
The half-life of Oxapro is approximately 8–15 hours.
Clearance
The clearance of Oxapro is approximately 24–48 liters per hour.
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