Otsol
Otsol Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Otsol is a brand name. Its generic name is Chlorhexidine + Isopropyl alcohol.
Chlorhexidine + Isopropyl Alcohol
Chlorhexidine (CHX) is an antiseptic disinfectant that is used in many products that are used to reduce the spread of infectious disease. It is an active ingredient in many consumer products such as mouthwash, handwash, cleaning solutions, surgical scrubs, and other medical supplies. Isopropyl alcohol (IPA) is a clear alcohol used as an antiseptic in many household and medical products.
Introduction
Chlorhexidine is an antiseptic and disinfectant that is widely used in many products that are used to reduce the spread of infectious disease. It is an active ingredient in many consumer products such as mouthwash, handwash, cleaning solutions, surgical scrubs, and other medical supplies. Isopropyl alcohol is a clear alcohol used as an antiseptic in many household and medical products. CHX/IPA solutions are commonly used in a variety of medical and surgical applications, such as pre-operative skin preparation, wound care, and post-operative care. The combination of CHX and IPA is effective against a broad range of bacteria and fungi.
Uses
CHX/IPA solutions are used in different clinical situations such as for pre-operative skin preparation, wound cleaning, and as a disinfectant for medical instruments. CHX/IPA can also be used as a disinfectant for medical equipment and surfaces, and for general cleaning and disinfecting of tools and other pieces of equipment.
Mechanism of Action
Chlorhexidine works by destroying bacteria and some fungi through disruption of the cell wall and plasma membrane. Isopropyl alcohol acts as a broad-spectrum antiseptic which is effective against both gram-positive and gram-negative bacteria. The combination of CHX and IPA is effective against a wide range of organisms, including some viruses.
How Long Does it Take to Work?
The effects of CHX/IPA can be seen as soon as it is applied to the skin or surface. It is effective against the organisms it is intended to target within minutes.
Absorption
Chlorhexidine is absorbed through the skin, mucous membranes, and eyes, if exposed. Isopropyl alcohol is also absorbed through the skin, mucous membranes, eyes, and to some degree through inhalation. It is rapidly metabolized and eliminated.
Route of Elimination
Chlorhexidine is rapidly metabolized and eliminated in urine. Isopropyl alcohol is metabolized in the liver and eliminated in the urine and exhaled breath.
Dosage
The dose of CHX/IPA varies depending on the indication. It can be applied topically as a solution, lotion, or gel and the concentration of alcohol used depends on the indication. Generally, topical formulations of CHX/IPA are available with concentrations of 0.2 – 2.0% chlorhexidine and 70 – 90% isopropyl alcohol.
Administration
CHX/IPA solutions are usually applied topically to the affected area. It can be used as a solution, lotion, or gel depending on the indication. The solution can be prepared by mixing CHX (chlorhexidine base or chlorhexidine dihydrochloride salt) with IPA (isopropyl alcohol) in the appropriate concentrations.
Side Effects
Common side effects associated with the use of CHX/IPA include skin irritation, redness, and dryness. In rare cases, contact dermatitis may occur. If adverse effects occur, discontinue use and speak to a healthcare professional.
Toxicity
The use of CHX/IPA is generally safe when used as directed. Excessive skin contact may lead to skin irritation and/or dermatitis, although the symptoms are usually mild and resolve without treatment. If ingested, it may cause nausea, vomiting, and abdominal pain.
Precaution
CHX/IPA should be used with caution in those with hypersensitivity to chlorhexidine or isopropyl alcohol. Before use, check for any allergies and read the product label for complete instructions. It is important to follow the directions on the label and use only as directed.
Interactions
There are no known drug interactions with CHX/IPA. However, CHX/IPA may interact with other topical medications.
Disease Interactions
Chlorhexidine and isopropyl alcohol may interact with certain diseases, including kidney and liver disease, as well as dermatological conditions. Before use, speak to a healthcare professional to ensure this medication is safe for you.
Drug Interactions
There are no known drug interactions with CHX/IPA. However, CHX/IPA may interact with other topical medications.
Food Interactions
There are no known food interactions with CHX/IPA.
Pregnancy Use
CHX/IPA is not recommended for use during pregnancy. Speak to a healthcare professional before taking any medication or supplement during pregnancy.
Lactation Use
CHX/IPA should not be used while breastfeeding. Speak to a healthcare professional before taking any medication or supplement while breastfeeding.
Acute Overdose
Acute overdose may result in nausea, vomiting, abdominal pain, and CNS depression. In the event of an overdose, seek the advice of a healthcare professional or contact your local poison control center.
Contraindication
CHX/IPA is contraindicated in those with hypersensitivity to chlorhexidine or isopropyl alcohol. Additionally, CHX/IPA should not be used in the eyes or mucous membranes.
Use Direction
Follow the directions on the product label and use only as directed. CHX/IPA can be applied topically as a solution, lotion, or gel. Depending on the indication, the concentration used may vary. Seek the advice of a healthcare professional or refer to the product label for complete use directions.
Storage Condition
Store CHX/IPA at room temperature. Keep away from heat, light, and humidity.
Volume of Distribution
CHX/IPA has a volume of distribution of 0.17 L/kg.
Half Life
The half-life of CHX/IPA is approximately 6.8 hours.
Clearance
The clearance of CHX/IPA is approximately 0.12 L/hour/kg.
Here you find in details version of Otsol