Orlis

Orlis Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Orlis is a brand name. Its generic name is Orlistat.

Orlis Introduction

Orlis is a medicine used for weight management. It belongs to a group of medicines known as gastrointestinal lipase inhibitors, or GI lipase inhibitors, and it works by reduing the amount of fat that is absorbed by the body. Orlis is available both over-the-counter (OTC) and in prescription form, and is marketed under various brand names, such as Xendos and Alli.

Uses for Orlis

Orlis is used to help enhance weight loss in overweight adults who are taking part in a weight-loss program. It is also used in certain patients for obesity management. Orlis may be used in conjunction with other medications and a reduced-calorie diet to achieve greater weight-loss.

Mechanism Of Action

Orlis works by inhibiting the absorption of fat in your body. It does this by inhibiting an enzyme in the stomach and intestines called lipase. The lipase enzyme helps the body break down and absorb fat. When Orlis blocks the action of the lipase enzyme, less fat is absorbed from the diet, resulting in a smaller increase in blood fat levels.

In addition to its weight loss benefits, Orlis can also reduce triglyceride levels and improve blood cholesterol levels. This is important because both elevations in triglyceride levels and blood cholesterol levels are associated with an increased risk of cardiovascular disease.

How Long Does It Take To Work?

The effectiveness of Orlis depends on its adequate and consistent use. Most people will begin to see results within three months of regularly taking the dosage of Orlis prescribed by their doctor. However, it is important to follow the recommended instructions to maximize the effects of the medication.

Absorption

Orlis is mostly not absorbed in the body, it mainly works in the lower intestine and only a small amount is absorbed into the bloodstream. The medication is broken down by the gut bacteria in the lower intestine.

Route Of Elimination

The inactive metabolites are eliminated as feces, and the active form of the drug is eliminated in urine.

Dosage

The recommended dose of Orlis is one 120 mg capsule, taken orally with a full glass of liquid, three times a day. Orlis is generally taken during, or up to one hour after each main meal of the day. The missed doses should be skipped and the regular schedule should be resumed.

Administration

Orlis can be taken orally with a full glass of liquid either before, during or up to one hour after each meal. It should not be taken more than three times a day.

Side Effect

The most common side effects associated with Orlis include gas with discharge, loose stools, abdominal pain, fecal urgency, difficulty controlling bowel movements, increased bowel movements, diarrhea, nausea, and headache.

Toxicity

Orlis is relatively nontoxic and the most severe side effect can be gastrointestinal (GI) distress. If Orlis is taken with meals that are very high in fat, the side effects may be more pronounced. In such cases, Orlis should be discontinued until the symptoms resolve.

Precaution

Before taking Orlis, you should tell your doctor if you have ever had any type of liver or kidney problems. You should also tell your doctor if you have gallbladder problems or if you are pregnant or plan to become pregnant.

Interaction

Orlis should not be taken with certain medications such as warfarin, because it can reduce the effectiveness of the warfarin and increase the risk of bleeding. Orlis should also not be taken with some vitamins, as their absorption may be reduced.

Disease Interaction

Orlis may interact with certain disease states and alter their natural history. For example, Orlis has been linked to reduced risk of Crohn's disease, colorectal cancer, and type 2 diabetes. It is important to discuss any potential interactions with your doctor before taking Orlis.

Drug Interaction

Certain drugs may interact with Orlis. For example, if you take anticoagulants, such as warfarin, the effectiveness of the drug may be reduced by Orlis. In addition, some medications, such as thyroid hormones, can interact with Orlis.

Food Interactions

Orlis should be taken with meals that contain less than 30% fat in order for it to be most effective. Foods such as nuts, seeds, fried foods, creamy sauces, gravies, and high-fat dairy products should be avoided, as these foods tend to be high in fat.

Pregnancy Use

Orlis is not recommended for women who are pregnant, breastfeeding, or trying to become pregnant as it may interfere with the absorption of important nutrients. Women should also not take Orlis if they are nursing, as it may interfere with the production of breast milk.

Lactation Use

It is not recommended for breastfeeding women to take Orlis, as it may interfere with the production of breast milk.

Acute Overdose

In the event of an overdose, the patient should stop taking the medication and seek immediate medical attention. Signs and symptoms of an overdose may include abdominal cramps, nausea, and diarrhea.

Contraindication

Orlis is contraindicated in patients with chronic malabsorption syndromes, as well as those with known hypersensitivity to Orlis or any of its components.

Use Directions

Orlis should be taken as directed by your physician. Generally, the recommended dose is one 120mg capsule taken with a full glass of liquid up to three times a day with meals. Orlis should not be taken with meals that contain more than 30% fat. It is important to follow the instructions provided by your physician in order to maximize the effectiveness of the medication.

Storage Conditions

Orlis should be stored at room temperature away from moisture and light. It should be kept out of the reach of children and pets.

Volume Of Distribution

Orlis has a volume of distribution of 11.7 L and is not significantly bound to plasma proteins.

Half Life

The half life of Orlis is approximately 1 to 2 hours.

Clearance

The clearance of Orlis is approximately 20 L/h.

Here you find in details version of Orlis

Some Frequently Asked Questions About Orlis

What is Orlis?

Orlis is a prescription weight loss medication which is used to aid in weight loss, or to help reduce the risk of regaining weight already lost.

What does Orlis do?

Orlis works by blocking some of the fat that you consume from being absorbed by your body. This helps you to reduce the amount of fat absorbed from your diet, helping you to lose weight and reduce the risk of regaining weight.

How long does Orlis take to start working?

Orlis should begin to take effect within a few days of starting treatment. However, the effects of Orlis will be most noticeable after you have been using it for a few weeks.

What is a typical dose of Orlis?

The recommended dose of Orlis is one capsule three times a day, taken during or up to one hour after each main meal. Do not take more than the recommended dose.

How long can I take Orlis for?

Orlis should only be taken for a maximum of six months. After six months, it is recommended that you have a break of one month before starting the treatment again. That said, if you are still losing weight after six months, consider changing to a different form of weight loss treatment.

Can I buy Orlis over the counter?

No, Orlis is only available with a valid prescription from your doctor or another healthcare professional.

Does Orlis have any side effects?

Like all medications, Orlis can cause side effects. Common side effects of Orlis include changes in bowel habits, oily spotting, passing gas, and an increased number of bowel movements. Speak to your doctor if you experience any side effects while taking Orlis.

Is Orlis suitable for everyone?

No, Orlis is not suitable for everyone. If you have any underlying health condition, such as liver or kidney disease, Orlis is not suitable for you. Speak to your doctor or pharmacist before taking Orlis.

Does Orlis interact with other medications?

Yes, Orlis may interact with other medications. Therefore, it is important to tell your doctor or pharmacist about all medications you are taking, before starting Orlis, to ensure that all interactions are avoided.

Does Orlis cause weight loss without dieting?

No, Orlis does not cause weight loss without dieting. Orlis is used to aid weight loss, or to help reduce the risk of regaining weight already lost. It is important to stick to a reduced calorie, low-fat diet whilst taking Orlis in order to achieve the best results.

Is Orlis suitable for people with diabetes?

Yes, Orlis may be suitable for people with diabetes. However, it is important to discuss this with your doctor, in case any additional dietary advice is needed. Additionally, if you are taking any diabetes medications, it is important to tell your doctor before starting Orlis.

What should I do if I forget to take Orlis?

If you forget to take a dose of Orlis, simply take it as soon as you remember. Do not take a double dose to make up for the dose that you have missed.

Does Orlis have any long-term effects?

No, Orlis does not have any long-term effects. Once you stop taking Orlis, any unwanted effects should stop within a few days.

Does Orlis interact with any herbal remedies?

Yes, you should not take any herbal remedies whilst taking Orlis, as they may interact and cause unwanted side effects. Always tell your doctor or pharmacist about any herbal remedies you are taking before starting Orlis.

Does Orlis cause weight gain?

No, Orlis does not cause weight gain. In fact, it is used to aid weight loss or to help reduce the risk of regaining weight already lost.

Is Orlis suitable for children?

No, Orlis is not suitable for children. Orlis is a weight loss medication for adults over the age of 18 only.

Does Orlis work without exercise?

No, Orlis should only be taken in conjunction with a calorie-controlled diet and regular exercise. Taking Orlis without dieting or exercise is unlikely to be effective.

Is Orlis safe to use while breastfeeding?

It is not recommended to take Orlis when breastfeeding. Speak to your doctor for further advice on how to safely lose weight while breastfeeding.

Is Orlis available on the NHS?

Yes, Orlis is available on the NHS for people with a BMI over 30, and those with a BMI over 28 who have other health risks associated with being overweight or obese.

Is Orlis safe to take while pregnant?

No, Orlis is not safe to take while pregnant. Speak to your doctor or midwife for advice on safe weight loss while pregnant.

Does Orlis cause constipation?

Orlis may cause changes to your bowel habits. If you experience constipation while taking Orlis, speak to your doctor or pharmacist for advice on how to prevent or relieve it.

How quickly will I lose weight when taking Orlis?

Weight loss with Orlis will vary from person to person. However, you should aim to lose at least 5% of your starting weight during the first three months of treatment.

What foods should I avoid while taking Orlis?

It is important to stick to a reduced-calorie, low-fat diet while taking Orlis. Foods that are high in saturated fat, such as full-fat dairy products, processed foods, and fried foods should be avoided.

Is Orlis related to fat burning?

No, Orlis is not related to fat burning. Orlis works by blocking some of the fat that you consume from being absorbed by your body. This helps you to reduce the amount of fat absorbed from your diet, helping you to lose weight and reduce the risk of regaining weight.

How often should I take Orlis?

The recommended dose of Orlis is one capsule three times a day, taken during or up to one hour after each main meal. Do not take more than the recommended dose.

How should Orlis be stored?

Orlis should be stored at room temperature, away from moisture and heat. Ensure the capsule is tightly closed when not in use. Keep all medications out of the reach of children.

Can Orlis be used for weight loss in people with type 2 diabetes?

Yes, Orlis may be used to aid weight loss in people with type 2 diabetes. However, it is important to speak to your doctor first, as any additional dietary advice may be needed.

Does Orlis cause fatigue?

Fatigue is not a common side effect of Orlis. If you experience any unwanted side effects while taking Orlis, such as fatigue, speak to your doctor or pharmacist for advice.

Is Orlis suitable for vegetarians?

Yes, Orlis is suitable for vegetarians as the capsules are made from ingredients derived from plant sources.

Does Orlis cause nausea?

Nausea is not a common side effect of Orlis. However, speak to your doctor or pharmacist if you experience any unwanted side effects while taking Orlis.

Is diet and exercise essential for taking Orlis?

Yes, a calorie-controlled diet and regular exercise are essential for achieving the best results when taking Orlis. Try to exercise at least five times a week, for at least 30 minutes per day. Additionally, it is important to stick to a healthy, balanced diet to ensure your body is getting the nutrients that it needs.

What is the best way to take Orlis?

The best way to take Orlis is to take the capsule during or up to one hour after each main meal. Do not take more than the recommended dose and stick to a calorie-controlled diet and regular exercise for best results.

Can Orlis be taken long-term?

No, Orlis should not be taken long-term. Orlis should only be taken for a maximum of six months. After six months, it is recommended that you have a break of one month before starting the treatment again. That said, if you are still losing weight after six months, consider changing to a different form of weight loss treatment.

Is Orlis safe to take for a long period of time?

No, Orlis should not be taken for a long period of time. Orlis should only be taken for a maximum of six months. After six months, it is recommended that you have a break of one month before starting the treatment again. That said, if you are still losing weight after six months, consider changing to a different form of weight loss treatment.

How long after taking Orlis can I drink alcohol?

Alcohol should be avoided while taking Orlis. Alcohol may further reduce the absorption of fat from the body, leading to fluctuations in blood sugar levels. It is recommended to avoid alcohol until after you have finished your course of Orlis.

How quickly will I notice results when taking Orlis?

Weight loss with Orlis will vary from person to person. However, you should aim to lose at least 5% of your starting weight during the first three months of treatment. Results should begin to be noticeable within a few days of starting Orlis, but the effects will be more noticeable after you have been using it for a few weeks.

Can I take Orlis if I am taking other medications?

Yes, it is possible to take Orlis if you are taking other medications. However, it is important to tell your doctor or pharmacist about any other medications you are taking, before starting Orlis, to ensure that all interactions are avoided.

Can I take Orlis while on other forms of weight loss treatments, such as weight watchers?

Yes, you can take Orlis while on other forms of weight loss treatments, such as weight watchers. However, speak to your doctor or pharmacist if you are considering combining Orlis with any other weight loss treatments, as drug interactions may occur.

Does Orlis cause any permanent changes to my body?

No, Orlis does not cause any permanent changes to your body. Any unwanted effects should stop within a few days of stopping treatment.

Can Orlis be used to treat obesity?

Yes, Orlis can be used to aid weight loss for people with obesity. However, it is important to stick to a reduced-calorie, low-fat diet and regular exercise for best results.