Onriva Plus Bexicap
Onriva Plus Bexicap Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Onriva Plus Bexicap is a brand name. Its generic name is Indacaterol + Glycopyrronium.
Indacaterol and Glycopyrronium Introduction
Indacaterol and glycopyrronium is a combination medication that is used to treat chronic obstructive pulmonary disease (COPD). This combination inhalation therapy helps to control the symptoms of COPD and improve patient breathing. It works by relaxing the muscles in the airways and opening them so that the lungs can receive more air.
Uses For
Indacaterol and Glycopyrronium is indicated for the long-term maintenance treatment of airflow obstruction in patients with COPD, including chronic bronchitis and/or emphysema. It can also be used to reduce the frequency and severity of exacerbations (exacerbations are sudden and worsening of episodic COPD symptoms).
Mechanism Of Action
Indacaterol is a long-acting beta-2 agonist (LABA). It works by stimulating the beta-2 receptors in the lungs which relaxes the airways, making it easier for the patient to breathe and prevents reflex bronchospasm. Glycopyrronium is an anticholinergic (anti-muscarinic) medication that works by inhibiting the release of acetylcholine, a neurotransmitter that stimulates constriction of the airways.
How Long Does It Take To Work
Indacaterol and Glycopyrronium typically begins working in the lungs within a few minutes after inhaling it. Peak effects are typically reached within two to four hours.
Absorption
Indacaterol and Glycopyrronium are rapidly absorbed in the lungs and absorbed in the gastrointestinal tract. Both medications are highly protein-bound and widely distributed in the body.
Route Of Elimination
Indacaterol and Glycopyrronium are primarily eliminated through the kidneys.
Dosage
Indacaterol and Glycopyrronium is available in two inhalation formulations: an inhalation powder (IND/GLP 85/15 mcg) and an inhalation solution (IND/GLP 183/14 mcg). The recommended dose is one inhalation once daily using the inhalation powder or one inhalation twice daily using the inhalation solution.
Administration
Indacaterol and Glycopyrronium is meant to be inhaled through the mouth. Patients should be instructed to use the inhalation powder using an inhalation bronchodilator device, and to use the inhalation solution using either a nebulizer or a metered-dose inhaler. Patients should also be instructed to rinse with water after use to reduce risk of infection.
Side Effect
Common side effects of Indacaterol and Glycopyrronium include nausea, headaches, throat irritation, coughing, and dry mouth. Less common side effects include dizziness, muscle pain, and difficulty sleeping.
Toxicity
No signs of major toxicity have been observed with the use of Indacaterol and Glycopyrronium. However, prolonged use of high doses may cause side effects such as excessive bronchial hyperresponsiveness and tremor.
Precaution
Patients should avoid using excessive doses of Indacaterol and Glycopyrronium as it may lead to serious side effects. Patients should also be aware of the possibility of exacerbation or reduced therapeutic efficacy when discontinuing or changing the dose of the drug.
Interactions
Indacaterol and Glycopyrronium may interact with other medications, including certain antibiotics and antifungals. Patients should inform their doctor of any other medications they are taking, including herbal supplements, before taking Indacaterol and Glycopyrronium.
Disease Interactions
Individuals with asthma, bronchitis, emphysema, bronchiectasis, or other conditions affecting the respiratory system should be monitored closely while taking Indacaterol and Glycopyrronium to ensure that the drug is effective and no severe side effects are experienced.
Drug Interactions
Indacaterol and Glycopyrronium may interact with other drugs, such as beta-blockers, calcium channel blockers, certain antidepressants, MAO inhibitors, and certain anticonvulsants. Patients should inform their doctor of any other medications they are taking before taking Indacaterol and Glycopyrronium.
Food Interactions
No food interactions have been reported for Indacaterol and Glycopyrronium.
Pregnancy Use
Indacaterol and Glycopyrronium should not be used during pregnancy unless the potential benefit outweighs the potential risks. Women should inform their healthcare provider if they are pregnant or planning to become pregnant before using the medication.
Lactation Use
It is not known if Indacaterol and Glycopyrronium is excreted into breast milk. Women who are breastfeeding should talk to their doctor before taking Indacaterol and Glycopyrronium.
Acute Overdose
Symptoms of an overdose may include headache, dizziness, nausea, vomiting, tremor, palpitations, tachycardia, and hypotension. Patients should contact their doctor or seek medical attention if they experience any of these symptoms.
Contraindication
Indacaterol and Glycopyrronium is contraindicated in patients who are hypersensitive to any of its components. It is also contraindicated in patients with severe hypersensitivity to milk proteins. Patients with severe cardiovascular disorders, severe hypertension, or hyperthyroidism should not take this medication.
Use Direction
Indacaterol and Glycopyrronium must be used according to the instructions provided by the doctor. Patients should also be instructed on how to properly use the inhalation device. The inhaler device should not be used with a spacer or during a high-humidity environment.
Storage Condition
Indacaterol and Glycopyrronium should be stored at room temperature between 20°C and 25°C (68°F and 77°F). The inhaler should be kept dry, and out of the reach of children.
Volume Of Distribution
The volume of distribution of Indacaterol and Glycopyrronium is approximately 4L/kg.
Half Life
The half-life of Indacaterol and Glycopyrronium is approximately 72 hours.
Clearance
Indacaterol and Glycopyrronium is cleared primarily by the kidneys.
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