Olmetic Plus

Olmetic Plus Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Olmetic Plus is a brand name. Its generic name is Olmesartan + Hydrochlorothiazide.

Introduction

Olmesartan and Hydrochlorothiazide (commonly referred to as Olmesartan+HCTZ or OlmesartanHCTZ) is a combination medication used to treat high blood pressure. It is composed of two drugs, Olmesartan, which is an angiotensin II receptor antagonist, and Hydrochlorothiazide, which is a diuretic.

Uses For

Olmesartan+HCTZ is used to treat high blood pressure (hypertension). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. This medication may also be used to treat heart failure.

Mechanism of Action

Olmesartan is an angiotensin II receptor antagonist (or ARB). It works by blocking the action of certain natural substances that tighten the blood vessels, so blood flows more smoothly. Hydrochlorothiazide is a thiazide diuretic (water pill). It helps to draw water from the body, which helps keep the amount of salt and water in balance. The combined action of both drugs helps to reduce blood pressure by blocking the effects of the angiotensin II hormone and increasing the excretion of salt and water through the kidneys.

How Long Does it Take to Work?

The effects of this medication usually begin within 1-2 weeks. Consult with your doctor as to when you are likely to start feeling relief from your symptoms.

Absorption

The olmesartan component of this medication is well absorbed and does not require calibration for timing of administration relative to meals. Hydrochlorothiazide is well absorbed when taken orally.

Route of Elimination

The elimination route of olmesartan and HCTZ components of this medication is excreted mostly through urine, although some may be excreted in the feces. Olmesartan is metabolized to a limited extent.

Dosage

Olmesartan + HCTZ is typically available in tablets of varying dosages, such as 10 mg/12.5 mg, 20 mg/12.5 mg, 20 mg/25 mg and 40 mg/25 mg. The physician or medical provider will determine the appropriate dosage based on individual patient response and need. Generally, dosage should be taken in compliance with the manufacturer's directions. Patients should not change or stop taking this medication unless instructed to do so by their healthcare provider.

Administration

This medication should typically be taken once daily, with or without food. Patients should swallow the tablets whole, with a glass of water. Do not crush, dissolve, or split tablets.

Side Effects

Common side effects of Olmesartan+HCTZ include dizziness, lightheadedness, headache, fatigue, weakness, nausea, and dry coughing. If any of these side effects worsen or persist, patients should speak to their doctor as soon as possible.

Toxicity

Neither olmesartan nor hydrochlorothiazide have any significant toxicity when taken as directed. However, as with any medication, overdoses should be avoided as they can lead to serious medical complications. If an overdose is suspected, it is important to seek medical attention immediately.

Precautions

Patients should inform their doctor prior to taking Olmesartan+HCTZ if they have allergies to the drugs contained in the medication, kidney problems, liver problems, gout, lupus, problems urinating, diabetes, or if they are pregnant or breastfeeding. It is also important to tell your doctor about all medicines you are taking, including vitamins and supplements, as they may interact with the medication.

Interactions

Olmesartan+HCTZ may interact with other medications, including vaccinations, antacids, NSAIDs, ACE inhibitors, antihistamines, lithium, and other angiotensin receptor blockers. It is important to tell your doctor before taking this medication if you are taking any of these medications as they may interact with this medication.

Disease Interactions

Olmesartan+HCTZ may interact with diseases, including aortic stenosis, hepatic impairment, and chronic kidney disease. Patients should inform their doctor of any chronic diseases before starting this medication.

Drug Interactions

Drug interactions occur when Olmesartan+HCTZ interacts with other medications, such as aspirin, ibuprofen, warfarin, or lithium. Consult with your doctor or pharmacist before taking this medication if you are taking any of these medications. It is also important to tell your doctor about any herbal supplements, vitamins, or other medicines you are taking as they may interact with this medication.

Food Interactions

There are no known food interactions with Olmesartan+HCTZ. However, alcohol can reduce the effectiveness of this medication and worsening side effects.

Pregnancy Use

Women of childbearing age should discuss their current use of Olmesartan+HCTZ with a healthcare provider if they are pregnant or planning to become pregnant. This medication is categorized as a "pregnancy Category D" and may be harmful to an unborn baby.

Lactation Use

Olmesartan+HCTZ should be used with caution in nursing mothers as it can pass through the mother’s milk. It is important to talk to your healthcare provider about any health concerns for the mother when breastfeeding.

Acute Overdose

If an overdose is suspected, contact a poison control center or emergency room immediately. Symptoms of an overdose include severe headaches, hypotension, confusion, weakness, and collapse.

Contraindication

Olmesartan+HCTZ is not recommended for those with certain medical conditions, including anuria, hypersensitivity to any component of the medication and a history of angioedema. It is also contraindicated for women who are pregnant as it may be harmful to the unborn baby.

Use Direction

Follow all directions exactly as prescribed by your doctor. Never take more or less of the medication than your doctor has prescribed. It is also important to take this medication regularly for the duration of your treatment.

Storage Conditions

Olmesartan+HCTZ should be stored at room temperature away from light and moisture. Do not keep this medication in the bathroom, refrigerator, or freezer. Do not double-dose and do not mix the two drugs together.

Volume of Distribution

The volume of distribution of olmesartan is 10.0 L/kg and the volume of distribution for hydrochlorothiazide is 1.6 L/kg.

Half Life

The plasma elimination half-life of olmesartan is 13 to 15 hours and the plasma elimination half-life for hydrochlorothiazide is 8 to 27 hours.

Clearance

The clearance of olmesartan is 0.4 L/hr/kg and the clearance of hydrochlorothiazide is 0.3 L/hr/kg.

Here you find in details version of Olmetic Plus

Some Frequently Asked Questions About Olmetic Plus

What is Olmetic Plus?

Olmetic Plus is a combination drug containing olmesartan and hydrochlorothiazide. It is used to treat high blood pressure (hypertension).

What are the side effects of Olmetic Plus?

The most common side effects of Olmetic Plus include low blood pressure, dizziness, headache, nausea, vomiting, stomach pain, and fatigue. More serious side effects may include difficulty breathing, swelling of the face, throat, tongue, or lips, and a rash.

What is the dosage of Olmetic Plus?

The usual initial dose of Olmetic Plus is one tablet containing 20 mg of olmesartan and 12.5 mg of hydrochlorothiazide once daily.

Who should not take Olmetic Plus?

Olmetic Plus should not be taken by people who are allergic to any of its components. People with severe kidney, liver, or heart problems should not take this medication, as its safety and efficacy have not been established in these patient groups.

Can Olmetic Plus be taken during pregnancy?

No, Olmetic Plus should not be taken during pregnancy. It may cause harm to an unborn baby. Women who are pregnant or planning to become pregnant should not take Olmetic Plus.

Can Olmetic Plus be taken with alcohol?

It is not recommended to take Olmetic Plus with alcohol as it can increase the risk of certain side effects, such as low blood pressure.

Can Olmetic Plus be taken with other medications?

It may not be advisable to take Olmetic Plus with certain medications. Before taking Olmetic Plus, it is important to tell your doctor about any other medications you are taking, including over-the-counter drugs, herbal remedies, and supplements.

What are the possible drug interactions of Olmetic Plus?

Taking Olmetic Plus with certain medications can increase the risk of side effects, including low blood pressure or changes in the levels of electrolytes such as calcium and potassium. Some drugs that may interact with Olmetic Plus include nonsteroidal anti-inflammatory drugs (NSAIDs) and diuretics.

How long does it take for Olmetic Plus to work?

It usually takes 1 to 2 weeks for Olmetic Plus to start to reduce blood pressure. It may take months or even longer for the full effects of the drug to be seen.

Is Olmetic Plus addictive?

No, Olmetic Plus is not addictive.

What should I do if I miss a dose of Olmetic Plus?

If you miss a dose of Olmetic Plus, take it as soon as you remember. If it is close to your next dose, skip the missed dose and take the next dose at the regular time.

What should I do if I overdose on Olmetic Plus?

If you take too much Olmetic Plus, seek medical attention immediately. Symptoms of overdose may include dizziness, nausea, vomiting, and low blood pressure.

What should I know before taking Olmetic Plus?

Before taking Olmetic Plus, tell your doctor about any other medications you are taking, including over-the-counter drugs, herbal remedies, and supplements. Also, be sure to inform your doctor of any allergies or medical conditions you have. Olmetic Plus may not be suitable for everyone.

Can I take other medications with Olmetic Plus?

Not all medications may be safe to take when combined with Olmetic Plus. Before taking any other medications, including over-the-counter drugs, herbal remedies, and supplements, be sure to tell your doctor about them. Your doctor can help you decide if it is safe to take these medications together.

Can Olmetic Plus be used to treat other conditions?

No, Olmetic Plus is not approved to treat any conditions other than high blood pressure (hypertension).

How long can I take Olmetic Plus?

Olmetic Plus can be taken as long as it is necessary to control your blood pressure. Be sure to talk to your doctor as they can recommend the best treatment plan for you.

Can I stop taking Olmetic Plus suddenly?

It is generally not advisable to stop taking Olmetic Plus suddenly as this could cause your blood pressure to rise significantly. Your doctor can work with you to gradually reduce the dosage as needed.

Can women take Olmetic Plus?

Yes, women can take Olmetic Plus. However, it is important to inform your doctor if you are pregnant or if you are planning to become pregnant. Some medications are not safe to take during pregnancy.

Can Olmetic Plus be taken with other blood pressure medications?

Yes, Olmetic Plus can be taken with other blood pressure medications. Be sure to tell your doctor about all of the medications you are taking, so that they can decide if it is safe to take them together.

How long does it take for Olmetic Plus to start to work?

It usually takes 1 to 2 weeks for Olmetic Plus to start to reduce blood pressure. It may take months or even longer for the full effects of the drug to be seen.

Does Olmetic Plus cause drowsiness?

No, Olmetic Plus does not usually cause drowsiness. However, some people may experience fatigue or dizziness due to the effects of the medication. If this occurs, it is important to contact your doctor.

Do I need to have regular blood tests while taking Olmetic Plus?

Yes, it is important to have regular blood tests while taking Olmetic Plus. Your doctor can monitor your blood pressure levels to ensure that the drug is working effectively.

Does Olmetic Plus cause weight gain?

No, Olmetic Plus does not usually cause weight gain. However, some people may see a slight increase in their weight, which is due to the drug's diuretic effect.

Can I take other medications while taking Olmetic Plus?

Not all medications may be safe to take when combined with Olmetic Plus. Before taking any other medications, including over-the-counter drugs, herbal remedies, and supplements, be sure to tell your doctor about them. Your doctor can help you decide if it is safe to take these medications together.

What should I do if I experience side effects with Olmetic Plus?

If you experience any side effects with Olmetic Plus, contact your doctor as soon as possible. Contact your doctor immediately if you experience side effects such as difficulty breathing, swelling of the face, throat, tongue, or lips, or a rash.

What is the maximum daily dose of Olmetic Plus?

The maximum daily dose of Olmetic Plus is 40 mg of olmesartan and 25 mg of hydrochlorothiazide. Your doctor can change your dose if needed.

Where can I buy Olmetic Plus?

Olmetic Plus is available with a prescription from your doctor. It can also be purchased at most local pharmacies.

What should I avoid while taking Olmetic Plus?

You should avoid drinking alcohol while taking Olmetic Plus, as alcohol may increase the risk of certain side effects. You should also avoid driving or operating machinery if you experience any dizziness or fatigue while taking the medication.

What is the difference between Olmetic Plus and other anti-hypertensive drugs?

Olmetic Plus is a combination drug, meaning that it contains two active ingredients (olmesartan and hydrochlorothiazide) that work together to reduce blood pressure. Other anti-hypertensive drugs may have different and potentially fewer side effects, depending on the active ingredients and dosage.

What is the shelf life of Olmetic Plus?

The shelf life of Olmetic Plus is 2 years. Be sure to read the expiration date on the package to make sure the medication is still good.

Can Olmetic Plus be taken with food?

Yes, Olmetic Plus can be taken with or without food. Your doctor can provide specific instructions on how to take the medication.

Is Olmetic Plus safe for long-term use?

Yes, Olmetic Plus is considered to be safe for long-term use, provided that you have regular bloodwork and follow your doctor's instructions. Your doctor can also provide more information on the safety of long-term use.