Nomigran
Nomigran Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Nomigran is a brand name. Its generic name is Sumatriptan.
What is Nomigran?
Nomigran is a medication used to treat migraine headaches. It belongs to a class of medications known as serotonin receptor agonists, and works by reducing inflammation and constricting dilated blood vessels in the brain, helping to relieve migraine pain.
Uses for Nomigran
Nomigran is used to treat migraine headaches, as well as other conditions where severe headaches are present. It can also be used to prevent migraine headaches in those patients who suffer from frequent migraines. It is also used to treat other types of headaches such as cluster headaches.
Mechanism of Action
Nomigran works by constricting dilated blood vessels in the brain that can cause the migraines. It also reduces inflammation in the head, neck, and scalp. It is believed to work by activating serotonin receptors in the brain, which helps to regulate pain.
How Long Does It Take To Work?
Nomigran usually begins to work within 30 minutes, although it can take up to two hours for the full effects to be seen. The medication should only be taken when you feel a migraine coming on. Take mid-treatment as needed if the pain still persists.
Absorption
Nomigran is rapidly absorbed after oral administration, with peak drug concentrations occurring 1 to 4 hours after dosing. The mean oral bioavailability of sumatriptan is 69%.
Route of Elimination
Nomigran is primarily excreted in the urine in the form of metabolites. It has a half-life of 2.5 to 3.3 hours.
Dosage
Nomigran is available in 25, 50, and 100 mg tablets. The recommended dose for an adult is 25 to 100 mg orally, taken with or without food. It can be taken up to 4 times a day as needed. For children under 12, a dosage of 25 to 50 mg orally every 4 to 6 hours as needed, up to a maximum of 200 mg in a 24-hour period.
Administration
Nomigran should be taken orally with or without food. To ensure best results, follow the dosage instructions provided by your doctor. Do not change the dosage without first consulting a doctor.
Side Effects
Common side effects of sumatriptan include nausea, drowsiness, dizziness, and flushing. Rare but serious side effects can include chest pain, heart problems, vision changes, seizures, and difficulty breathing. If any of these side effects occur, seek medical attention immediately.
Toxicity
Nomigran is generally well-tolerated and has a low risk of toxicity when taken according to instructions. However, an overdose of sumatriptan can be dangerous and may be life-threatening. Symptoms of an overdose include dizziness, confusion, drowsiness, and seizures.
Precautions
Nomigran should be used with caution in patients with a history of stroke, heart attack, or bleeding disorders. It can also interact with certain medications, so it is important to let your doctor know of any other medications you may be taking before starting treatment with sumatriptan.
Interactions
Nomigran can interact with certain medications, including MAO inhibitors, blood thinners, and certain antibiotics and antifungals. Patients should discuss any other medication they are taking with their health care provider before using Nomigran.
Disease Interaction
Nomigran is not recommended for use in patients with uncontrolled hypertension, cerebral or coronary vasospasm, severe hepatic or renal impairment, and ischemic heart disease.
Drug Interaction
Nomigran should not be taken with any drugs in the monoamine oxidase (MAO) inhibitor family. These include phenelzine (Nardil), isocarboxazid (Marplan), and tranylcypromine (Parnate). If you are taking any of these medications, tell your doctor before taking Nomigran.
Food Interactions
Nomigran should not be taken with foods that are high in tyramine content such as aged cheeses, sour cream, certain meats, smoked fish, and certain beers. Alcohol can also interfere with the effectiveness of Nomigran. Try to avoid drinking alcohol while taking this medication.
Pregnancy Use
It is not recommended to take sumatriptan during pregnancy. This medication can cross the placenta and potentially harm a developing fetus. It is important to discuss any potential risks with your health care provider before beginning treatment with sumatriptan.
Lactation Use
The safety of sumatriptan in breastfeeding women has not been established. It is recommended that women who are breastfeeding either avoid or discontinue breastfeeding while taking this medication.
Acute Overdose
The symptoms of acute overdose with sumatriptan are similar to those experienced with an overdose of other medications in this class. Symptoms can include drowsiness, confusion, rapid or irregular heartbeat, seizures, coma, and death.
Contraindication
Nomigran is contraindicated in patients with an allergy to the medication and in those with certain pre-existing medical conditions, including ischemic heart disease, uncontrolled hypertension, severe hepatic or renal impairment, and cerebral or coronary vasospasm.
Use Direction
Take sumatriptan exactly as directed by your healthcare provider. The recommended dose is 25 to 100 mg orally, taken with or without food, up to 4 times daily as needed for migraine symptoms. Do not exceed 200 mg in a 24-hour period.
Storage Condition
Nomigran should be stored at room temperature, away from moisture and heat. Keep out of the reach of children and pets.
Volume of Distribution
The volume of distribution for sumatriptan is 17 L/kg.
Half Life
The half-life of sumatriptan is 2.5 to 3.3 hours.
Clearance
Nomigran has an oral clearance of 35.6 L/hr/kg.
Here you find in details version of Nomigran
Some Frequently Asked Questions About Nomigran
What is Nomigran?
Nomigran is a medication used to treat acute migraine and cluster headaches by constricting blood vessels around the brain.
How does Nomigran work?
Nomigran works by regulating the level of a neurotransmitter (serotonin) that is involved in initiating migraine attacks. It binds to the serotonin receptors on the walls of blood vessels, causing them to constrict and reduce the inflammation and pain caused by a migraine.
Is Nomigran safe to use during pregnancy?
Nomigran should not be used during pregnancy, as it has not been studied extensively. Speak to your healthcare provider if you need medication to treat your migraine while pregnant.
What is the dosage of Nomigran?
The recommended starting dose of Nomigran is 25-100 mg by mouth, depending on severity of symptoms. It is important to take Nomigran at the first onset of symptoms and not to wait until they become severe.
Are there any side effects associated with Nomigran?
The most common side effects associated with Nomigran are dizziness, tingling sensations, nausea, and muscle tightness or pain. Other side effects may occur. Speak with your healthcare provider if you experience any side effects.
Who should not take Nomigran?
Patients with certain medical conditions such as heart disease, stroke, or uncontrolled blood pressure, should not take Nomigran. Speak with your doctor before taking Nomigran if you have any of these conditions.
What should I do if I miss a dose of Nomigran?
If you miss a dose of Nomigran, take it as soon as possible. Missing a dose should not affect the effectiveness of Nomigran as long as it is taken at the onset of symptoms.
How long does it take Nomigran to start working?
Nomigran typically starts working within 30 minutes of taking a dose. The effects may vary from person to person.
What if Nomigran does not work for my migraine?
If Nomigran does not work for your migraine, speak with your healthcare provider, as other treatments may be available.
Are there any drug interactions with Nomigran?
Nomigran should not be taken with certain medications that increase serotonin levels, as this can cause serious side effects. Speak with your healthcare provider before taking Nomigran if you are taking any other medications.
Can Nomigran be taken with other medications for migraine treatment?
Nomigran should not be taken with other medications used to treat migraines as this can lead to serious side effects. Speak with your healthcare provider before taking Nomigran if you are taking other medications for migraine treatment.
Does Nomigran have any long-term effects?
Although Nomigran is generally safe for short-term use, there is no evidence to suggest its long-term safety. Speak with your healthcare provider if you plan to take Nomigran for a long period of time.
What should I do if I overdose on Nomigran?
If you overdose on Nomigran, seek medical attention immediately. Overdosing on Nomigran can be dangerous and can lead to serious side-effects and even death.
Can Nomigran be taken with foods or beverages?
Nomigran can be taken with or without food. It is important to check with your doctor before taking Nomigran with any beverage or food, as some can interfere with the medication's effectiveness.
How long will the effects of Nomigran last?
The effects of Nomigran usually last up to 24 hours. Speak with your healthcare provider if your symptoms continue after taking Nomigran.
Is Nomigran habit-forming?
Nomigran is not habit-forming and can be used as needed for acute migraine symptoms. However, it is important to speak with your healthcare provider if you plan to use it frequently or have concerns about addiction or abuse.
Is Nomigran covered by insurance?
Nomigran may be covered by your insurance, depending on your plan. It is best to contact your insurance provider to find out if it is covered by your plan.
What are the possible allergic reactions to Nomigran?
The most common allergic reactions to Nomigran are allergic reactions including skin rash, hives, itching, or difficulty breathing. If you experience any of these symptoms, stop taking Nomigran immediately and contact your healthcare provider.
How long can I take Nomigran?
Nomigran can be taken as needed to treat migraine attacks, but it should not be used for more than 10 days per month to avoid overuse and decreasing effectiveness of the drug.
What is the cost of Nomigran?
The cost of Nomigran depends on the dose and form (oral tablet, nasal spray, injection, etc). Speak with your doctor or pharmacist for more information about the cost of Nomigran.
Can I take Nomigran if I have high blood pressure?
Nomigran can be taken by patients with high blood pressure, but it is important to speak with your doctor first to make sure that it is safe for you to take Nomigran.
Can Nomigran be taken daily?
Nomigran should not be taken daily, as this can lead to overuse and decreased effectiveness of the drug. Speak with your healthcare provider to find out if Nomigran is the right medication for you.
What are the signs of a Nomigran overdose?
Signs of a Nomigran overdose can include seizures, confusion, chest pain, irregular heartbeat, difficulty breathing, and coma. If you experience any of these symptoms, seek medical attention immediately.
Can I take Nomigran if I am taking other medications?
Nomigran should not be taken with certain medications that increase serotonin levels, as this can cause serious side effects. Speak with your healthcare provider before taking Nomigran if you are taking any other medications.
Can Nomigran be taken on an empty stomach?
Nomigran can be taken with or without food, but it is important to check with your healthcare provider before taking it on an empty stomach.
Does Nomigran cause drowsiness?
Nomigran can cause drowsiness in some people, though this is usually mild and does not last long. Speak with your healthcare provider if you experience any drowsiness while taking Nomigran.
What should I avoid while taking Nomigran?
It is important to avoid drinking alcohol while taking Nomigran, as this can increase the risk of serious side effects. Speak to your healthcare provider if you have any questions or concerns.
Can I take Nomigran if I am breastfeeding?
Nomigran is not recommended for use while breastfeeding, as it has not been studied extensively. Speak with your healthcare provider if you need medication to treat your migraine while breastfeeding.
Can Nomigran be taken with other medications for headache treatment?
Nomigran should not be taken with other medications used to treat migraines as this can lead to serious side effects. Speak with your healthcare provider before taking Nomigran if you are taking other medications for headache treatment.
Is Nomigran prescribed for children?
Nomigran is not generally recommended for use in children, as its safety and effectiveness in this age group have not been established. Speak with your healthcare provider for more information.
What medications should not be taken with Nomigran?
Nomigran should not be taken with certain medications that increase serotonin levels, as this can cause serious side effects. Speak with your healthcare provider before taking Nomigran if you are taking any other medications.
What is the maximum dose of Nomigran I can take?
The maximum recommended dose of Nomigran is 300 mg per 24 hours. Speak to your healthcare provider if you need to increase your dose, as higher doses can increase the risk of serious side-effects.
Should I take Nomigran if I have a history of stroke or heart problems?
Patients with certain medical conditions such as heart disease, stroke, or uncontrolled blood pressure, should not take Nomigran. Speak with your doctor before taking Nomigran if you have any of these conditions.
Can I drive or operate machinery after taking Nomigran?
It is not recommended to drive or operate machinery after taking Nomigran, as it can cause drowsiness. Speak with your healthcare provider if you have any questions or concerns.
Are there any other medications I can take for my migraine?
Your healthcare provider may recommend other medications for migraine treatment such as non-steroidal anti-inflammatory drugs (NSAIDs) or migraine-specific prevention medications. Speak with your doctor for more information.
What should I do if Nomigran does not work for my migraine?
If Nomigran does not work for your migraine, speak with your healthcare provider, as other treatments may be available.
Can I take Nomigran while pregnant?
Nomigran should not be used during pregnancy, as it has not been studied extensively. Speak to your healthcare provider if you need medication to treat your migraine while pregnant.
What can I do to prevent migraine attacks?
There are several lifestyle changes that you can make to prevent migraine attacks. These include getting regular exercise, eating a healthy diet, avoiding triggers such as certain foods and smells, and getting enough sleep.
How should I store Nomigran?
Nomigran should be stored at room temperature, away from moisture and heat. It should also be kept out of reach of children.
Can I take Nomigran if I am taking other medications?
Nomigran should not be taken with certain medications that increase serotonin levels, as this can cause serious side effects. Speak with your healthcare provider before taking Nomigran if you are taking any other medications.
Is there an alternative to Nomigran?
If Nomigran is not effective for you, your doctor may recommend other medications for migraine treatment such as non-steroidal anti-inflammatory drugs (NSAIDs) or migraine-specific prevention medications.