Nofenac

Nofenac Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Nofenac is a brand name. Its generic name is Aceclofenac.

Introduction

Nofenac is a non-steroidal anti-inflammatory drug (NSAID) used to manage pain, swelling, and inflammation due to various medical conditions. It is the racemic mixture of the two forms of a compound. It was developed in 1968 and approved for medical use in 1993.

Uses

Nofenac is used to treat symptoms of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. It is also used in the treatment of musculoskeletal disorders, such as neck and back pain, sports injuries, sprains and strains, tendinitis, and bursitis.

Mechanism of Action

Nofenac works by blocking the production of prostaglandins, hormones that cause inflammation and pain. By blocking this action, it reduces the pain and inflammation caused by these conditions.

How Long Does It Take to Work?

Nofenac typically takes up to 2 weeks for its effect to be fully manifested. However, most patients experience relief within a few days.

Absorption

Nofenac is rapidly absorbed from the gastrointestinal tract. It is metabolized in the liver and excreted in the urine and feces.

Route of Elimination

Nofenac is secreted in the urine and feces. It is also partially metabolized by the liver.

Dosage

Nofenac is available in 50 mg, 100 mg, and 200 mg doses. The recommended dose is one to two tablets taken orally every 8-12 hours as needed for pain relief. The maximum daily dose is 800 mg per day. The dose may be increased or decreased based on individual response and tolerance.

Administration

Nofenac tablets should be taken orally, with or without food, as directed by your doctor. The tablets should be swallowed whole and should not be chewed or crushed.

Side Effects

Common side effects of Nofenac include gastrointestinal discomfort, nausea, headache, dizziness, and rash. Serious side effects include difficulty breathing, chest pain, and liver or kidney problems. Contact your doctor if you experience severe or persistent side effects.

Toxicity

Nofenac is generally well-tolerated, however, overdoses can result in serious toxicity. Symptoms of overdose include blurred vision, difficulty breathing, confusion, seizures, and coma. Seek immediate medical attention if you or someone you know has overdosed on this medication.

Precaution

Nofenac should be taken with caution if you have a history of kidney, liver, or gastrointestinal disorder, asthma, dehydration, or blood clotting disorder. You should also avoid taking alcohol or other medications that can irritate the stomach while taking aceclofenac.

Interactions

Nofenac may interact with certain other medications. Be sure to inform your doctor of any medications, supplements, or vitamins you are currently taking. This medication may also interact with other medical conditions or lifestyle choices.

Drug Interactions

Nofenac can interact with certain other medications, including anti-inflammatory drugs, antidepressants, blood thinners, antibiotics, antifungal medications, and vitamin supplements. Be sure to tell your doctor and pharmacist about all medications you are currently taking, including any over-the-counter medications.

Food Interactions

Nofenac may interact with certain foods. It is important to talk to your doctor about any dietary restrictions or food interactions that may occur when taking this medication.

Pregnancy Use

Nofenac should not be used during pregnancy as it may cause harm to the fetus. Women who are pregnant or planning to become pregnant should not take this medication.

Lactation Use

Nofenac should not be used during lactation as it may be secreted into breast milk. Women who are breastfeeding should not take this medication.

Acute Overdose

Overdose of aceclofenac can be potentially life-threatening. Symptoms of overdose include, blurred vision, difficulty breathing, confusion, seizures, and coma. Seek immediate medical attention if you or someone you know has overdosed on this medication.

Contraindication

Nofenac should not be used in people with a history of stomach or intestinal ulcer, liver and kidney disease, and patients with a history of hypersensitivity to other drugs including Nofenac.

Use Direction

Nofenac should be taken exactly as prescribed by your doctor. Do not take more or less of the medication than directed. Do not take the medication more or less frequently than directed.

Storage Condition

Nofenac should be stored at room temperature, away from light, moisture, and heat. Keep away from children and pets.

Volume of Distribution

Nofenac has a large volume of distribution and is widely distributed throughout the body.

Half Life

The elimination half-life of aceclofenac is approximately 6 hours.

Clearance

Nofenac is cleared from the body primarily by the kidneys. The oral clearance of the drug is approximately 40 mL/min.

Here you find in details version of Nofenac

Some Frequently Asked Questions About Nofenac

What is Nofenac?

Nofenac is a non-steroidal anti-inflammatory drug (NSAID) used for treating pain and inflammation in conditions such as rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis.

What is the mechanism of action of Nofenac?

Nofenac is thought to work by inhibiting the activity of the enzyme cyclooxygenase (COX). Inhibition of COX leads to decreased synthesis of pro-inflammatory and painmediating prostaglandins, resulting in a reduction in inflammation and pain.

What is the dosage of Nofenac?

The recommended adult dose of Nofenac is 100 to 200 mg twice daily or as directed by the physician.

What are the side effects of Nofenac?

The common side effects of Nofenac include stomach upset, heartburn, nausea, vomiting, diarrhea, drowsiness, headache, constipation, joint pain, rash and itching.

What should be avoided while taking Nofenac?

Alcohol should be avoided while taking Nofenac as it can increase the risk of stomach ulcers and bleeding. ACE inhibitors, anticoagulants, diuretics, NSAIDs, and corticosteroids should also be avoided while taking Nofenac.

Can Nofenac be used for migraine?

Nofenac is not usually recommended for the treatment of migraine headaches, although some patients may find it to be effective. Patients should discuss this with their doctor to determine if Nofenac is an appropriate treatment.

Can I take Nofenac with paracetamol?

Yes, it is safe to take Nofenac with paracetamol. However, it is important to follow the dosages as prescribed by your doctor, and not to exceed the recommended dosages.

Can I take Nofenac during pregnancy?

Nofenac is not recommended during the first and third trimester of pregnancy. There is limited data on its use and safety during the second trimester of pregnancy, and it should be used only if the potential benefits outweigh the risks.

Is Nofenac a muscle relaxant?

No, Nofenac is not a muscle relaxant. It is a non-steroidal anti-inflammatory drug (NSAID) used to reduce pain and inflammation in conditions such as rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis.

Can Nofenac be used for headaches?

Nofenac is not usually recommended for the treatment of headache. Patients should discuss this with their doctor to determine if Nofenac is an appropriate treatment.

What are the serious side effects of Nofenac?

Serious side effects of Nofenac include signs of allergic reactions (hives, difficulty breathing, swelling of the face, lips, tongue, or throat), chest pain, increased blood pressure, shortness of breath, and bloody or black, tarry stools.

What is the difference between Nofenac and Ibuprofen?

Nofenac and ibuprofen are both non-steroidal anti-inflammatory drugs (NSAIDs) used for reducing pain and inflammation. The main difference between them is that Nofenac is thought to have fewer gastrointestinal side effects than ibuprofen.

Can I take Nofenac if I have high blood pressure?

Yes, you can take Nofenac if you have high blood pressure. However, it is important to follow the dosages as prescribed by your doctor, and not to exceed the recommended dosages.

Is Nofenac safe?

Nofenac is generally safe and well-tolerated when taken at prescribed doses. However, it can cause side effects such as stomach upset, heartburn, nausea, vomiting, diarrhea, drowsiness, headache, constipation, joint pain, rash and itching.

Can Nofenac be used to treat fever?

No, Nofenac is not usually recommended for the treatment of fever. It is used to reduce pain and inflammation associated with conditions such as rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis.

How long does Nofenac take to work?

Nofenac usually starts to work within a few hours of taking it. Maximum effects are usually seen within 1-2 weeks.

Can I take Nofenac with warfarin?

No, it is not recommended to take Nofenac with warfarin as it could increase the risk of bleeding. If you are taking warfarin then you should discuss this with your doctor before taking Nofenac.

What is the maximum daily dose of Nofenac?

The maximum daily dose of Nofenac is 400 mg per day. Higher doses are not recommended and patients should not exceed the recommended dose.

Is Nofenac available over the counter?

No, Nofenac is a prescription medication available only through a doctor's prescription.

Is Nofenac a strong painkiller?

Nofenac is a medium strength painkiller used for treating pain and inflammation in conditions such as rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis.

Can Nofenac be used to treat gout?

Yes, Nofenac can be used to treat gout. However, it is important to follow the dosage as prescribed by the doctor and not to exceed the recommended dosage.

Can Nofenac be taken with food?

Yes, it is generally recommended to take Nofenac with food or after meals to reduce the risk of stomach upset. It is important to follow your doctor's instructions when taking this medication.

Can I take Nofenac before surgery?

No, it is not recommended to take Nofenac before surgery as it may increase the risk of bleeding. You should discuss this with your doctor before taking this medication.

What should be done in case of an overdose?

If an overdose of Nofenac is suspected then medical attention should be sought immediately. Symptoms of an overdose may include nausea, vomiting, dizziness, abdominal pain, and drowsiness.

What precautions should I take while using Nofenac?

It is important to follow all the instructions and precautions provided by the doctor while taking Nofenac. It is also important to keep your doctor updated about any medical conditions you have and be aware of any medications, supplements, or herbal remedies you are taking that could interact with Nofenac.

What drug interactions can occur when taking Nofenac?

Nofenac may interact with certain drugs, such as ACE inhibitors, anticoagulants, diuretics, NSAIDs, and corticosteroids. It is important to discuss with your doctor any medications, supplements, or herbal remedies you are taking, to prevent any potential drug interactions.

Is Nofenac safe for long-term use?

Nofenac is generally safe when taken for a short period of time. Long-term use of Nofenac can increase the risk of side effects, such as gastrointestinal bleeding, increased risk of heart attack, stroke, and kidney damage. If you are taking Nofenac for a long-term period, it is important to discuss this with your doctor.

Can Nofenac cause anemia?

Yes, long-term use of Nofenac can cause anemia due to decreased production of red blood cells. If you are taking Nofenac for long-term use, it is important to discuss with your doctor about the potential risks of anemia.

Can Nofenac cause liver damage?

Yes, Nofenac can cause liver damage in rare cases. If you experience any signs of liver damage such as yellowing of the eyes or skin, dark urine, or abdominal pain, you should seek medical attention immediately.

Can Nofenac cause kidney damage?

Yes, long-term use of Nofenac can cause kidney damage in rare cases. If you experience any signs of kidney damage such as decreased urination, nausea, vomiting, or fluid retention, you should seek medical attention immediately.

Can Nofenac cause weight gain?

No, Nofenac does not usually cause weight gain. However, it is possible for certain side effects, such as abdominal pain, nausea, and vomiting, to lead to decreased appetite and weight loss.

Can I take Nofenac with aspirin?

No, it is not recommended to take Nofenac with aspirin as it may increase the risk of stomach ulcers and bleeding. If you are taking aspirin then you should discuss this with your doctor before taking Nofenac.

Can I take Nofenac for menstrual cramps?

Yes, Nofenac can be used to treat mild to moderate menstrual cramps. However, it is important to follow the dosage as prescribed by the doctor and not to exceed the recommended dosage.

Does Nofenac cause drowsiness?

Yes, Nofenac may cause drowsiness. If you experience drowsiness after taking this medication then it is important to avoid activities that require alertness such as driving or operating machinery.

Does Nofenac interact with warfarin?

Yes, Nofenac can interact with warfarin and increase the risk of bleeding. If you are taking warfarin then you should discuss this with your doctor before taking Nofenac.

What is the onset of action of Nofenac?

The onset of action of Nofenac is usually within a few hours of taking it. Maximum effects are usually seen within 1-2 weeks.

How long does Nofenac take to work?

The effects of Nofenac may take a few hours to be felt. Maximum effects are usually seen within 1-2 weeks.

Is Nofenac safe for children?

Nofenac is not recommended for use in children under 12 years of age. If a child needs to take this medication then it should be taken only under the supervision of a doctor.

Can Nofenac be taken with food?

Yes, it is generally recommended to take Nofenac with food or after meals to reduce the risk of stomach upset. It is important to follow your doctor's instructions when taking this medication.

What is the half-life of Nofenac?

The half-life of Nofenac is approximately 8 to 12 hours.

Is Nofenac addictive?

No, Nofenac is not addictive.

Can I take Nofenac if I have asthma?

Yes, you can take Nofenac if you have asthma. However, it is important to discuss this with your doctor to ensure that Nofenac is