Nitofa
Nitofa Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Nitofa is a brand name. Its generic name is Nitrofurazone.
Nitofa Introduction
Nitofa is an antibacterial agent belonging to Furanone family. Nitofa is a widely used topical antimicrobial agent to treat a variety of bacterial and fungal infections in humans and animals. It is available as a topical cream for short-term use or an ointment for long-term use.
Uses For
Nitofa is used to treat minor skin infections caused by bacteria. It is also used to treat burns, ulcers, and abscesses.
Mechanism of Action
Nitofa works by blocking bacterial growth. It interferes with several bacterial enzymes and inhibits bacterial DNA replication and transcription.
How Long Does It Take To Work
Nitofa usually takes between 1 to 2 hours to start killing bacteria. It can take up to 3 days to fully eliminate the bacterial infection.
Absorption
Nitofa is rapidly and completely absorbed into the skin. It has an absorption rate of approximately 90% when applied topically on the skin.
Route of Elimination
The drug is metabolized in the liver and is eliminated mainly through the urine.
Dosage
Nitofa should be applied to the affected area two to three times daily. The amount to be applied depends on the size of the area being treated. For adults, the recommended dose is 1 to 2 grams, and for children it is 0.5 to 2 grams.
Administration
Nitofa can be applied topically to the affected area and rubbed in lightly.
Side Effect
Side effects of Nitofa may include skin irritation, redness, itching, and dryness. It may also cause darkening or lightening of the skin.
Toxicity
Toxicity of Nitofa is rare and is usually mild when it does occur. It can cause dizziness, nausea, and diarrhea.
Precaution
Nitofa should not be used if you are pregnant or lactating, or if you have any kidney diseases. It should also not be used for a prolonged period of time as it may cause skin discoloration.
Interaction
- Nitofa may interact with certain medications, including antibiotics, blood thinners, and retinoid drugs.
Disease Interaction
- Nitofa may worsen certain medical conditions, including anemia, kidney disease, and liver disease.
Drug Interaction
- Nitofa may interact with certain other medications, such as ciprofloxacin, doxycycline, and minocycline.
Food Interactions
No food interactions have been reported with Nitofa.
Pregnancy Use
Nitofa is not recommended for use during pregnancy, especially in the first trimester. It may cause harm to the developing fetus.
Lactation Use
Nitofa is not recommended for use while lactating.
Acute Overdose
Symptoms of an acute Nitofa overdose can include nausea, vomiting, and dizziness. If an overdose is suspected, seek medical help immediately.
Contraindication
Nitofa is contraindicated in people with an allergy to Nitofa or any of its components.
Use Direction
Nitofa should be applied topically to the affected area and gently rubbed in for best effect. It should not be applied to broken skin or taken internally as it may cause harm.
Storage Condition
Nitofa should be stored at room temperature, away from heat and light, in a dry place.
Volume of Distribution
The volume of distribution of nitrofurazone is not known.
Half Life
The half-life of nitrofurazone is not known.
Clearance
The clearance of nitrofurazone is not known.
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