Nidipro

Nidipro Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Nidipro is a brand name. Its generic name is Atenolol + Nifedipine.

Nidipro Introduction

Nidipro is a combination of two medications, atenolol and nifedipine, used to treat high blood pressure. Atenolol is a beta-blocker that blocks certain hormones, while nifedipine is a calcium channel blocker that prevents calcium from entering the cells. Together, these medications provide synergistic action to reduce blood pressure.

Uses for Nidipro

Nidipro is used to treat high blood pressure (hypertension) in adults. This combination medication may also be used to prevent heart attacks and strokes in certain high-risk patients.

Mechanism of Action

Nidipro works by blocking certain hormones (beta-blockers) and preventing calcium from entering the cells (calcium channel blockers). These two medications work together to reduce overall blood pressure.

How Long Does It Take To Work?

Nidipro can take up to two weeks to become fully effective, though most people begin to see a decrease in their blood pressure within a few days of starting the medication.

Absorption

Nidipro is rapidly absorbed after oral administration, with peak blood concentrations reached 1 to 4 hours after dosing.

Route of Elimination

Nidipro is metabolised in the liver and excreted in the urine.

Dosage

The standard starting dose for Nidipro is one tablet taken once daily. Your doctor may adjust your dose depending on your response to the medication. It is important to take Nidipro at the same time every day and to not stop taking it suddenly.

Administration

Nidipro can be taken with or without food; with food may reduce the risk of side effects. Swallow the tablets whole with a full glass of water. Do not crush, chew, or break the tablets.

Side Effects

Nidipro can cause side effects such as dizziness, lightheadedness, fatigue, nausea, vomiting, or diarrhea. If you experience any serious side effects, such as chest pain or difficulty breathing, contact your doctor immediately.

Toxicity

Nidipro is generally well-tolerated, but it is possible to overdose on the medication. Symptoms of overdose include sluggishness, confusion, and shallow breathing. If you suspect an overdose, seek medical attention immediately.

Precaution

Nidipro should be used with caution in patients with kidney or liver disease, diabetes, thyroid disorders, cardiac arrest, and in those taking medications known to interact with Nidipro.

Interaction

Nidipro can interact with certain medications, including blood thinners, tricyclic antidepressants, and aspirin. It is important to tell your doctor about any medications you are taking before starting Nidipro.

Disease Interaction

Nidipro can interact with certain diseases, including diabetes, thyroid disorders, and heart failure. If you have any of these conditions, speak to your doctor before starting Nidipro.

Drug Interaction

Nidipro may interact with certain other medications, such as blood thinners, tricyclic antidepressants, and aspirin. It is important to tell your doctor about any medications you are taking before starting Nidipro.

Food Interactions

Nidipro can be taken with or without food; with food may reduce the risk of side effects.

Pregnancy Use

Nidipro is not recommended for use during pregnancy, as it may cause harm to the fetus.

Lactation Use

Nidipro is not recommended for use during breastfeeding as it may cause harm to the baby.

Acute Overdose

An acute overdose of Nidipro may cause symptoms such as slowed heartbeat, confusion, and shallow breathing. If you suspect an overdose, seek medical attention immediately.

Contraindication

Nidipro is contraindicated in patients with a known hypersensitivity or allergy to either of its components. It should also not be used by patients with a history of bradycardia, severe coronary artery disease, asthma, or COPD.

Use Direction

Nidipro should be taken as directed by your doctor. It is important to take Nidipro at the same time every day and to not stop taking it suddenly.

Storage Condition

Nidipro should be stored at room temperature away from moisture, heat, and light. It should also not be stored in the bathroom.

Volume of Distribution

Nidipro has a volume of distribution of 36.85-44.38 L/kg.

Half Life

Nidipro has a half-life of 3-6 hours.

Clearance

Nidipro has an average clearance of 12.50 +- 3.3 L/hr/kg.

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