Nidazole

Nidazole Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Nidazole is a brand name. Its generic name is Ornidazole.

Introduction

Nidazole is an antibiotic drug used to treat certain infections caused by bacteria, such as trichomonas, anaerobic bacteria, and protozoa. It is also sometimes used to treat urinary tract infections and skin and soft tissue infections. Nidazole works by interfering with the cell membranes of the bacteria and preventing them from growing and multiplying.

Uses For

Nidazole is primarily used to treat infections caused by trichomonas, anaerobic bacteria, and protozoa. It is used to treat vaginal, urinary tract, gastrointestinal, skin and soft tissue infections.

Mechanism of Action

Nidazole works by interfering with the cell membrane of the bacteria, preventing them from growing and multiplying. This prevents the bacteria from producing their own proteins and from replicating. As a result, the bacteria are destroyed and the infection is cleared up.

How Long Does It Take to Work?

Nidazole typically starts to take effect within a few days of treatment. However, it may take up to a few weeks for symptoms to completely clear up.

Absorption

Nidazole is absorbed from the gastrointestinal tract and rapidly metabolized in the liver. The drug is not significantly bound to plasma proteins.

Route of Elimination

Nidazole is eliminated mainly by metabolism in the liver and subsequent renal excretion of its metabolites. It is also mildly eliminated via biliary excretion.

Dosage

The usual adult dose of Nidazole is 500 mg twice daily for 7-14 days. Children should take 5 mg/kg/day (maximum 500 mg/day) divided twice daily for 10-14 days. Dosage may be adjusted for patients with renal impairment.

Administration

Nidazole should be taken with a full glass of water. It is covered and should be taken on an empty stomach, at least one hour before or two hours after meals.

Side Effects

The most common side effects of Nidazole include nausea, vomiting, abdominal pain, diarrhea, loss of appetite, and headache. Other side effects may include rash, itching, dizziness, and joint pain.

Toxicity

Nidazole can be toxic if taken in excess; high doses can cause nausea, vomiting, abdominal pain, and diarrhea. Overdose can lead to liver damage and other serious health complications.

Precaution

Nidazole should not be used by patients with renal impairment or by pregnant women. It should also not be used by patients who are hypersensitive to nitroimidazoles or pediatric patients younger than 6 years old. Before taking Nidazole, patients should inform their doctor about any other medications they may be taking.

Interaction

Nidazole can interact with other medications, including anticoagulants, cimetidine, and certain antacids. Drugs that reduce stomach acid can reduce the absorption of Nidazole. Alcohol should also not be consumed while taking Nidazole.

Disease Interaction

Nidazole may not be suitable for some people, such as those with liver or kidney disease. It can also interact with certain diseases, such as systemic lupus erythematosus or porphyria, so it is important to inform your doctor if you have any pre-existing conditions.

Drug Interaction

Nidazole can interact with other drugs, such as anticoagulants, cimetidine, and certain antacids. It may also interact with alcohol, so it is important to avoid drinking alcohol while taking Nidazole.

Food Interactions

Nidazole can interact with certain foods, so it is important to check with your doctor before consuming any food while taking this medication. Foods that can interact with Nidazole include fortified milk, certain dairy products, and certain antacids.

Pregnancy Use

Nidazole is not recommended for use in pregnant women. It should only be used if the potential benefits outweigh the potential risks, and only under the guidance of a qualified doctor.

Lactation Use

Nidazole has not been studied in nursing mothers, so its safety in this population is not known. It should be used with caution and only under the guidance of a qualified doctor.

Acute Overdose

Symptoms of an overdose include nausea, vomiting, abdominal pain, and diarrhea. It is important to seek immediate medical attention if an overdose is suspected.

Contraindication

Nidazole is contraindicated for use in patients with renal impairment, those who are hypersensitive to nitroimidazoles, and pediatric patients younger than 6 years old.

Use Direction

Nidazole should be taken as directed by your doctor. The usual adult dose is 500 mg twice daily for 7-14 days. Children should take 5 mg/kg/day (maximum 500 mg/day) divided twice daily for 10-14 days. Dosage may be adjusted for patients with renal impairment.

Storage Condition

Nidazole should be stored at room temperature, away from light and moisture. Keep out of reach of children and pets.

Volume of Distribution

The volume of distribution of Nidazole is 0.37 L/kg.

Half Life

The half-life of Nidazole is 2 to 4 hours.

Clearance

The clearance of Nidazole is 0.95 mL/min/kg.

Here you find in details version of Nidazole

Some Frequently Asked Questions About Nidazole

What is Nidazole?

Nidazole is an anti-parasitic medication used to treat certain infections caused by protozoa and anaerobic bacteria. It is also known by its brand name, Tiberal, and is available as a generic drug.

How is Nidazole taken?

Nidazole is taken orally, usually as tablets or capsules. It should be taken as prescribed by your doctor, usually once or twice a day.

What are the possible side effects of Nidazole?

The most common side effects include stomach upset, nausea, vomiting, and loss of appetite. More serious side effects include seizures, confusion, hallucinations, and muscle weakness. If you experience any of these side effects, contact your doctor immediately.

Can Nidazole be used to treat other infections?

Yes, Nidazole may be used to treat other infections, such as trichomoniasis and giardiasis. However, it is important to note that this medication is not approved for use in treating viral infections. Contact your healthcare provider for more information.

Can I drink alcohol when taking Nidazole?

It is not recommended to drink alcohol while taking Nidazole, as alcohol can increase the risk of side effects. Do not drink alcohol until you have discussed this with your doctor.

Can I take Nidazole if I'm pregnant or breastfeeding?

It is not recommended to take Nidazole if you are pregnant or breastfeeding. Talk to your healthcare provider to determine if this medication is safe for you.

Does Nidazole interact with any other medications?

Yes, Nidazole can interact with certain medications, including antacids, vitamin B6, and tretinoin. Be sure to discuss all of the medications you are taking with your healthcare provider before taking Nidazole.

How long does it take for Nidazole to work?

The amount of time it takes for Nidazole to work depends on the condition being treated. In most cases, symptoms should start to improve within a few days. However, it is important to keep taking Nidazole for the entire duration of treatment as prescribed by your doctor, even if symptoms seem to clear up.

What if I miss a dose of Nidazole?

If you miss a dose of Nidazole, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take the next dose at the regular time. Do not take two doses at once.

What are the storage requirements for Nidazole?

Nidazole should be stored at room temperature in a tightly closed container. Keep it away from direct light and moisture. Do not store Nidazole in the bathroom.

Can Nidazole be used to treat children?

Yes, Nidazole can be used to treat infections in children. However, the dosage and length of treatment may be different for children, so it is important to follow your doctor's instructions closely.

What is the usual dosage of Nidazole?

The usual dosage of Nidazole for adults is 500-750 mg taken once or twice daily, as prescribed by your doctor. The dosage for children may vary, depending on the condition being treated.

Is there any special monitoring required while taking Nidazole?

You may need to have blood tests to check your liver function while taking Nidazole. You may also need to have periodic tests to monitor your condition. Be sure to talk to your doctor about any tests you may need.

What should I do if I experience an allergic reaction after taking Nidazole?

If you experience an allergic reaction after taking Nidazole, stop taking the medication immediately and contact your doctor. Symptoms of an allergic reaction can include hives, swelling of the face, lips, and tongue, difficulty breathing, and chest tightness.

What happens if I overdose on Nidazole?

If you overdose on Nidazole, seek emergency medical attention right away. Symptoms of an overdose can include seizures, confusion, hallucinations, and muscle weakness.

Is Nidazole available over the counter?

No, Nidazole is not available over the counter. It must be prescribed by a doctor and filled at a pharmacy.

Does Nidazole treat all parasites?

No, Nidazole does not treat all parasites. It is only effective against certain parasites, such as protozoa and anaerobic bacteria. Talk to your doctor for more information.

Is Nidazole expensive?

The cost of Nidazole can vary depending on your insurance and the pharmacy you use. Talk to your doctor or pharmacist for more information about the cost of this medication.

Can Nidazole be used to treat bacterial infections?

Yes, Nidazole can be used to treat some bacterial infections, such as anaerobic bacterial infections. However, it is not effective against all bacterial infections. Talk to your doctor to determine the best treatment for your infection.

Can I take Nidazole with other medications?

Yes, you may be able to take Nidazole with other medications. However, it is important to talk to your doctor about all of the medications you are taking to make sure it is safe and effective. Some medications may interact with Nidazole, increasing the risk of side effects.

What if my symptoms do not improve while taking Nidazole?

If your symptoms do not improve after a few days of taking Nidazole, contact your doctor. It is possible that this medication is not the right treatment for your infection and your doctor may need to prescribe a different medication.

Are there any foods I should avoid while taking Nidazole?

Yes, it is important to avoid consuming alcohol while taking Nidazole, as it can increase the risk of side effects. Also, it is a good idea to avoid drinking grapefruit juice while taking this medication, as it can interfere with the way it works in the body.

Should I take Nidazole with food?

It is recommended to take Nidazole with food or a snack to reduce the risk of stomach upset. However, it is not necessary to take this medication with food to be effective.

Who should not take Nidazole?

Nidazole should not be taken by people who are allergic to this medication or any of its ingredients. People who are pregnant or breastfeeding should not take Nidazole unless specifically directed to do so by their healthcare provider.

Will taking Nidazole make me drowsy or affect my ability to drive?

Nidazole can cause drowsiness, dizziness, or blurred vision. If these side effects occur, it is important to not drive or operate any machinery until they subside. Talk to your doctor if these side effects persist.

What should I do if I forget to take a dose of Nidazole?

If you forget to take a dose of Nidazole, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take the next dose at the regular time. Do not take two doses at once.

Can I take Nidazole with other medications for parasites?

No, it is not recommended to take Nidazole with other medications for parasites. Talk to your doctor about the best treatment for your condition.

Does Nidazole treat any sexually transmitted diseases?

Yes, Nidazole may be used to treat certain sexually transmitted diseases, such as Trichomonas infection. However, it is not effective against all sexually transmitted diseases. Talk to your doctor for more information.

Is Nidazole safe for long-term use?

Yes, Nidazole is generally considered to be safe for long-term use. However, it is important to talk to your doctor about any risks associated with taking this medication long-term.

Can I take Nidazole if I have kidney or liver disease?

It is generally not recommended to take Nidazole if you have kidney or liver disease, as it can worsen your condition. Talk to your doctor for more information.

Does Nidazole affect a person's fertility?

No, Nidazole is not thought to affect a person's fertility. However, talk to your doctor if you have concerns about taking this medication.

Can Nidazole be used to treat parasites in the intestines?

Yes, Nidazole can be used to treat parasites in the intestines, such as Giardia infection. However, it is important to discuss all treatment options with your doctor.

What happens if I stop taking Nidazole before my infection is cured?

If you stop taking Nidazole before your infection is cured, the infection may not clear and you may experience a relapse of symptoms. Make sure to complete the full course of treatment as prescribed by your doctor.

Can I take Nidazole if I have allergies to other medications?

Yes, you may be able to take Nidazole if you have allergies to other medications. Be sure to discuss your history of allergies with your doctor before taking this medication.

Is Nidazole safe to take if I'm breastfeeding?

It is not recommended to take Nidazole if you are breastfeeding. Talk to your doctor to determine if this medication is safe for you.

How long does it take for Nidazole to be eliminated from the body?

It can take up to 4-7 days for Nidazole to be eliminated from the body. It is important to keep taking Nidazole for the full course of treatment as prescribed by your doctor.

Does Nidazole treat all intestinal infections?

No, Nidazole does not treat all intestinal infections. It is only effective against certain infections, such as those caused by protozoa and anaerobic bacteria.

Can I take Nidazole while taking Warfarin?

Yes, you may be able to take Nidazole while taking warfarin. However, it is important to talk to your doctor to make sure that it is safe and effective. Taking these two medications together may increase the risk of bleeding.

Does Nidazole affect the liver?

Yes, Nidazole can affect the liver. Talk to your doctor about the possibility of having regular blood tests to monitor your liver function while taking this medication.

Does Nidazole interact with birth control pills?

Yes, Nidazole can interact with certain types of birth control pills. If you are taking birth control pills, it is important to use an additional form of contraception while taking this medication to reduce the risk of an unintended pregnancy.