Nazle

Nazle, a brand name for a formulation containing essential Xylometazoline, is widely used for various health benefits. This guide provides comprehensive information on the uses, dosage, side effects, and mechanism of action of Nazle, as well as insights into how long it takes to work. Understanding these aspects can help you make informed decisions about its use and effectiveness.

Nazle Introduction

Nazle is a nasal decongestant drug of the imidazoline family. This medication is used to temporarily relive nasal congestion (stuffy nose) due to colds, flu, hay fever, allergies, and other breathing illnesses. Nazle is sometimes prescribed off-label to treat nasal polyps. It is also available in combination with other active ingredients in some products.

Uses for Nazle

Nazle is used to temporarily relive nasal congestion (stuffy nose) due to colds, flu, hay fever, allergies, and other breathing illnesses. It is also used to treat nasal polyps, off-label. It sometimes comes as a combination drug with other active ingredients in some products.

Mechanism of Action

Nazle works by stimulating alpha-adrenergic receptors located in the smooth muscles on the nasal mucosa, which produces a sympathomimetic effect of narrowing the vessels, leading to reduced nasal congestion. This reduction in swelling helps to open the nasal passages and clear the congestion.

How Long Does It Take To Work?

Nazle typically has a fast onset of action, usually within 15 minutes. Its duration of effect is usually around 12 hours, but some people may experience a shorter or longer duration.

Absorption

Nazle is rapidly absorbed through the mucous membranes of the nasal passages when administered topically. Its bioavailability is approximately 72%.

Route of Elimination

Nazle is primarily eliminated by hepatic metabolism.

Dosage

The recommended dosage for Nazle is typically 1-2 drops or sprays of 0.05% solution in the affected nostrils 2-3 times per day. Do not exceed more than 6 doses per day. For nasal polyps, the dosage is typically 2 sprays in the affected nostrils 3-4 times per day.

Administration

Nazle should be administered intranasally. Eliminate contact with eyes, and do not exceed dosage or duration of use as obstruction could occur.

Side Effects

While taking Nazle, common side effects may include irritation of the mucous membranes, sneezing, rhinorrhea, dryness, headache, and mild burning at the application site.

Toxicity

Nazle overdose can lead to serious effects such as hypertension, tachycardia, arrhythmias, circulatory collapse, and convulsions. Seek medical help if overdose is suspected.

Precaution

Nazle should not be used for more than 3 consecutive days or more than the recommended dose. Prolonged administration or excessive doses may cause a rebound effect in which the congestion returns with exaggerated intensity when Nazle is stopped. Discontinue use and contact a healthcare provider if any of these side effects occur.

Interaction

Nazle may interact with tricyclic antidepressants, phenothiazine derivatives, monoamine oxidase inhibitors, and other medications that have alpha-adrenergic blocking properties. If you are taking any of these medications, it is highly recommended to consult your physician before using Nazle.

Disease Interactions

Nazle may worsen certain medical conditions such as hypertension, stenocardia, arrhythmias, hyperthyroidism, and diabetes. If you have any of these conditions, it is advised to speak to your physician before using Nazle.

Drug Interactions

Since Nazle may interact with certain medications, it is important to tell your doctor if you are taking any medications, such as tricyclic antidepressants, phenothiazine derivatives, monoamine oxidase inhibitors, or medications that have alpha-adrenergic blocking properties. Do not start or stop any medication without consulting your doctor.

Food Interactions

No specific food interactions have been reported with Nazle. However, it is always advised to speak to your doctor before taking Nazle with any food or beverage, especially if you have an underlying medical condition.

Pregnancy Use

Nazle is not recommended for use in pregnant women due to lack of sufficient safety data. Women who are pregnant or planning to become pregnant should consult their doctor before using Nazle.

Lactation Use

Nazle is not recommended for use by breast-feeding women due to lack of sufficient safety data.

Acute Overdose

If Nazle overdose is suspected, seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Symptoms of overdose may include hypertension, tachycardia, arrhythmias, circulatory collapse, and convulsions.

Contraindication

Nazle should not be used by people who are allergic to it or any of its ingredients, people with glaucoma, people with narrow-angle glaucoma, people with severe heart disease, people with severe hypertension, people with an overactive thyroid, people with diabetes, and people who have taken a monoamine oxidase inhibitor (MAOI) within the past 14 days.

Use Direction

Nazle should be used as prescribed by your healthcare provider. For intranasal administration, the recommended dose is 1-2 drops or sprays of 0.05% solution in the affected nostrils 2-3 times per day. Do not exceed more than 6 doses per day or use for more than 3 consecutive days. Eliminate contact with eyes, and do not exceed dosage or duration of use as obstruction could occur.

Storage Conditions

Store Nazle at room temperature, away from light and moisture. Do not freeze. Keep it out of the reach of children and pets.

Volume of Distribution

The volume of distribution of Nazle is not known.

Half Life

The effective half-life of Nazle is about 4 hours.

Clearance

The clearance of Nazle is not known.

Here you find in details version of Nazle

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