Naproxen, a brand name for a formulation containing essential Naproxen, is widely used for various health benefits. This guide provides comprehensive information on the uses, dosage, side effects, and mechanism of action of Naproxen, as well as insights into how long it takes to work. Understanding these aspects can help you make informed decisions about its use and effectiveness.


Naproxen is a non-steroidal anti-inflammatory drug (NSAID) used to treat a wide range of painful conditions such as arthritis, migraine, muscle strain, and menstrual cramps.


Naproxen is used to temporarily relieve minor aches and pains due to arthritis, muscle strains, sprains, and bruises. It may also be used to temporarily reduce fever and to treat other conditions as determined by your healthcare provider.

Mechanism of Action

Naproxen works by blocking the production of prostaglandins, which are substances produced by the body that cause inflammation, pain and fever. By blocking the production of prostaglandins, naproxen is able to reduce inflammation, pain and fever.

How Long Does It Take To Work?

Naproxen usually starts to work within an hour after taking it, and most people will feel relief within four to six hours.


Naproxen is readily absorbed from the gastrointestinal tract. Peak concentrations in plasma generally occur from 1 to 4 hours after an oral dose.

Route of Elimination

Naproxen is primarily metabolized by the liver and is then eliminated from the body through urine. Naproxen is not known to be excreted in breast milk.


The usual adult dose of naproxen is 250 milligrams (mg) to 500 mg taken orally twice a day, with or after food. The maximum dose is 1,000 mg in a 24-hour period. For children 6 years and older, the recommended dose of naproxen is 7.5 mg per kilogram (3.4 mg per pound) of body weight per day, taken in 2 to 3 divided doses.


Naproxen should be taken by mouth as directed by your healthcare provider. It is important to take naproxen at the same time each day to avoid missing doses.

Side Effects

The most common side effects of naproxen are stomach upset, nausea, abdominal pain, indigestion, and headaches. Other less common side effects include ringing in the ears, dizziness, skin rash, hives, difficulty breathing, liver damage, and kidney damage.


Naproxen is generally considered to be a safe drug. Overdoses can cause serious medical problems, especially in older people, children, and people with medical conditions. Overdoses can cause nausea, vomiting, abdominal pain, drowsiness, seizures, and irregular heartbeats.


Naproxen should not be used if you have active or past bleeding in the stomach or intestine, have elevated levels of uric acid, have a history of ulcers, have severe liver or kidney disease, have active or past bleeding problems, are pregnant or nursing, are taking warfarin or other anticoagulant medicines, or have a history of allergic reactions to aspirin or other NSAIDs.


Naproxen can interact with other medications and supplements. Consult with your healthcare provider before taking any over-the-counter or prescription medications or supplements to ensure there will not be an interaction.

Disease Interactions

Naproxen is known to interact with certain medical diseases or conditions. Tell your healthcare provider about any medical diseases or conditions you may have before starting naproxen or any other medications.

Drug Interactions

Naproxen is known to interact with certain medications. Tell your healthcare provider about any medications or supplements you are taking, even if they are over-the-counter, to ensure there will not be an interaction.

Food Interactions

Naproxen should not be taken with alcohol. Additionally, grapefruit and grapefruit juice have the potential to interact with naproxen and should be avoided while taking this medication.

Pregnancy Use

Naproxen should be avoided in pregnant women and women who are planning to become pregnant. It should not be used during the first and third trimesters of pregnancy, when it has been associated with some birth defects.

Lactation Use

Naproxen should not be used by nursing mothers due to the potential for serious adverse effects in the nursing infant.

Acute Overdose

Acute overdose of naproxen can result in serious side effects such as drowsiness, seizures, coma, confusion, rapid heart rate, breathing problems, stomach upset, and vomiting. If you think you or someone else may have taken too much naproxen, seek emergency medical help right away.


Naproxen should not be used in people who have had a serious reaction to other NSAIDs, any allergies, or any active or past bleeding problems.

Use Directions

Naproxen should be taken exactly as directed by your healthcare provider. Do not take more or less than is prescribed and do not take it for a longer time than is recommended.

Storage Condition

Naproxen should be stored at room temperature, away from direct sunlight and heat. Keep out of the reach of children and pets.

Volume of Distribution

The volume of distribution of naproxen is approximately 0.6 liters per kilogram (L/kg).

Half Life

The half-life of naproxen is approximately 13 to 17 hours.


The clearance of naproxen is approximately 0.2 liters per hour (L/hr).

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