Motinorm

Motinorm Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Motinorm is a brand name. Its generic name is Domperidone.

Introduction

Motinorm is a dopamine antagonist and antiemetic agent used in the treatment of nausea and vomiting and in the management of gastrointestinal motility disorders.

Uses for

Motinorm is used to treat nausea, vomiting, and abdominal discomfort caused by gastric acid stasis, delayed gastric emptying, and gastroesophageal reflux disease (GERD). It is also used to increase lactation in nursing mothers.

Mechanism of Action

Motinorm is a dopamine antagonist that inhibits gastric emptying and increases lower esophageal sphincter pressure, thereby reducing acid reflux symptoms. Additionally, domperidone is thought to increase prolactin secretion from the anterior pituitary, stimulating breast milk production in nursing mothers.

Absorption

Motinorm is rapidly absorbed from the gastrointestinal tract after oral administration.

Route of Elimination

Motinorm is rapidly metabolized and eliminated, mainly through biliary excretion.

Dosage

Motinorm is available in tablets of 10 mg and 20 mg and in oral suspension of 10 mg/ml dosage forms. The recommended dose for adults is 10-20 mg three to four times a day.

Administration

Motinorm is administered orally. The tablets should be swallowed with a full glass of water and may be taken with food to reduce gastric irritation.

Side Effects

The most common side effects associated with domperidone include: nausea, vomiting, dizziness, drowsiness, headache, gastrointestinal discomfort, and breast enlargement in males.

Toxicity

Overdose of domperidone may lead to severe nausea, vomiting, dizziness, drowsiness, and hypotension.

Precautions

  • Patients should not take domperidone if they are sensitive or allergic to the drug.
  • Patients with kidney or liver disease should use domperidone with caution.
  • It is advised to use domperidone with caution in elderly patients and in patients with Parkinson’s disease.

Interaction

Motinorm may interact with other medications, including antacids, anticholinergics, antibiotics, antifungals, lithium, and some antipsychotic medications.

Disease Interaction

Motinorm may interact with certain diseases, such as Parkinson’s disease, kidney or liver disease, and liver cirrhosis.

Drug Interaction

Motinorm may interact with certain drugs, including antacids, anticholinergics, antibiotics, antifungals, lithium, and some antipsychotic medications.

Food Interactions

Motinorm may interact with certain foods, such as dairy products, alcohol, and caffeine.

Pregnancy Use

Motinorm should be used during pregnancy only if clearly needed and under the supervision of a qualified healthcare provider.

Lactation Use

Motinorm is excreted into breast milk in small amounts. Therefore, the use of domperidone should be avoided or monitored closely in nursing women.

Acute Overdose

Symptoms of an acute overdose of domperidone may include drowsiness, dizziness, nausea, and vomiting.

Contraindication

Motinorm is contraindicated in patients with known hypersensitivity to the drug.

Use Directions

The dosage of domperidone should be adjusted according to the individual patient's response. The tablets should be swallowed with a full glass of water and may be taken with food to reduce gastric irritation.

Storage Condition

Motinorm should be stored at room temperature in a light-resistant container.

Volume of Distribution

Following intravenous administration, the volume of distribution of domperidone is approximately 20 L.

Half Life

The half-life of domperidone is approximately 7-8 hours.

Clearance

The clearance of domperidone is approximately 4 L/h.

Here you find in details version of Motinorm

Some Frequently Asked Questions About Motinorm

What is domperidone?

Motinorm is a medication that is used to relieve symptoms like nausea and vomiting. It works by blocking the action of dopamine, a neurotransmitter in the brain, and by increasing the movement or contractions of the stomach and intestines, which helps move food through the digestive system.

What conditions are treated with domperidone?

Motinorm is commonly used to treat conditions such as nausea and vomiting, especially in cases of certain gastrointestinal disorders. It may also be prescribed to help stimulate milk production in breastfeeding women.

How does domperidone work to increase milk supply?

Motinorm stimulates the release of prolactin, a hormone that plays a key role in lactation. By increasing prolactin levels, domperidone helps boost milk production in breastfeeding women. It is often used when other methods to increase milk supply have not been successful.

What are the potential side effects of domperidone?

Common side effects of domperidone may include headache, dizziness, dry mouth, and abdominal cramps. In some cases, it may cause more serious side effects such as irregular heartbeats. It's important to seek medical attention if you experience any unusual or severe symptoms while taking domperidone.

Can domperidone be used during pregnancy?

Motinorm is generally not recommended for use during pregnancy unless the potential benefits outweigh the risks. It is important to discuss the risks and benefits with a healthcare provider before using domperidone during pregnancy.

Are there any drug interactions with domperidone?

Motinorm can interact with other medications, so it's essential to inform your healthcare provider about all the medications you are taking, including prescription, over-the-counter, and herbal supplements. Certain medications, such as those affecting heart rhythm, may interact negatively with domperidone.

Is a prescription required for domperidone?

In many countries, domperidone requires a prescription from a healthcare provider. It's important to follow your healthcare provider's instructions and not to self-prescribe or exceed recommended dosages without professional guidance.

Can domperidone be used for motion sickness?

While domperidone is primarily used for gastrointestinal issues and stimulating milk production, it is not typically prescribed for motion sickness. Other medications are more commonly recommended for preventing and treating motion sickness.

How should domperidone be taken?

Motinorm is usually taken before meals and at bedtime. It is important to follow the prescribed dosage and directions provided by your healthcare provider. The medication is typically taken for a short duration, and prolonged use should be done under medical supervision.

Can domperidone be used in children?

Motinorm may be prescribed for children under the guidance of a healthcare provider. The dosage and usage will be determined based on the child's age, weight, and medical condition. It's crucial to follow the healthcare provider's recommendations for pediatric use.

What should I do if I miss a dose of domperidone?

If you miss a dose of domperidone, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses to make up for a missed one.

Can domperidone be used for heartburn or acid reflux?

While domperidone is used to treat nausea and vomiting, it is not typically prescribed for heartburn or acid reflux. Proton pump inhibitors and H2 blockers are more commonly recommended for managing these conditions. Consult with a healthcare provider for appropriate treatment options.

Is domperidone available over-the-counter?

In many places, domperidone is available by prescription only. It's important to consult with a healthcare provider to determine if domperidone is a suitable option for your specific medical condition and to obtain a prescription if needed.

Can domperidone be used to treat irritable bowel syndrome (IBS)?

Motinorm is not typically prescribed for the treatment of irritable bowel syndrome (IBS). Its primary use is for gastrointestinal symptoms such as nausea and vomiting. Different medications and lifestyle modifications are often recommended for managing IBS symptoms.

How long does it take for domperidone to start working?

The onset of action of domperidone can vary from person to person. In general, it may take a few days to a week to experience the full therapeutic effects. It's essential to follow the prescribed dosage and continue the medication as directed by your healthcare provider.

Can domperidone cause allergic reactions?

Allergic reactions to domperidone are rare but possible. If you experience symptoms such as rash, itching, swelling, severe dizziness, or difficulty breathing, seek immediate medical attention. Inform your healthcare provider of any known allergies before starting domperidone.

Is it safe to drive or operate machinery while taking domperidone?

Motinorm may cause dizziness and drowsiness in some individuals. It's important to assess your individual response to the medication before engaging in activities that require mental alertness, such as driving or operating machinery. If you experience dizziness, avoid such activities until you know how domperidone affects you.

Can domperidone be used for weight loss?

Motinorm is not approved or recommended for weight loss. Its primary use is for gastrointestinal symptoms and stimulating milk production. Using domperidone for weight loss purposes is not safe and is not supported by medical evidence. Consult with a healthcare provider for appropriate weight management strategies.

What precautions should be taken when using domperidone?

Individuals with certain medical conditions, such as liver or kidney problems, should exercise caution when using domperidone. It's important to inform your healthcare provider of your complete medical history and all medications you are taking to ensure the safe and effective use of domperidone.

Can domperidone be used for morning sickness during pregnancy?

While domperidone is sometimes used for nausea and vomiting, it is not typically the first choice for morning sickness during pregnancy. Healthcare providers may recommend other medications or lifestyle changes for managing morning sickness. Always consult with a healthcare professional for guidance during pregnancy.