Metazine MR
Metazine MR Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Metazine MR is a brand name. Its generic name is Trimetazidine.
Introduction
Metazine MR is a anti-ischemic drug that is used to treat symptoms of angina pectoris (chest pain). Often referred to as a ‘metabolic modulator’, it works by modulating the way that energy is used by cells in the body, which can reduce chest pain and improve the efficiency of the heart muscle.Uses for
Metazine MR is used to reduce the frequency of angina attacks in patients with stable angina, improve their ability to exercise without chest pain, and reduce the need for other antianginal medications. It is also used to prevent further damage to the heart in certain conditions, such as arrhythmias, myocardial ischemia or infarction, and cardiomyopathies.Mechanism of Action
Metazine MR works by modulating the way energy is used by cells in the body. The drug works by inhibiting a metabolic process called fatty acid oxidation, which results in less energy being expended and more energy being stored, allowing the heart to work more efficiently and reducing the frequency of angina attacks.How Long Does it Take to Work?
Metazine MR typically takes up to two weeks to take full effect and may require regular, long-term use for optimal effectiveness. While it is not recommended to abruptly stop or replace trimetazidine with another medication without consulting a doctor, the effects of trimetazdine usually diminish in a few days if treatment is discontinued.Absorption
Metazine MR is absorbed rapidly after oral administration, with peak plasma concentration achieved approximately 2 hours after the dose is taken. Bioavailability may vary depending on the formulation and route of administration.Route of Elimination
Metazine MR is eliminated primarily in the feces, with small amounts excreted in the urine.Dosage
Metazine MR is typically given in an oral dose ranging from 20 to 60 mg taken three times daily, with meals. Some formulations are available in higher, twice daily doses, and may be better tolerated for some patients. Dosage should be tailored to the specific needs of the patient, and should not exceed 60 mg per day.Administration
Metazine MR should be taken orally, preferably with meals to reduce side effects.Side Effect
Common side effects of trimetazidine include abnormal taste in the mouth, constipation, nausea, diarrhea, and sleepiness. More serious side effects may include confusion and depression.Toxicity
Metazine MR is generally well-tolerated, with no evidence of significant toxicity at the recommended dosage. However, high doses may be associated with an increased risk of cardiac arrhythmias.Precautions
Metazine MR is not recommended in patients with kidney and liver disease, or those with history of arrhythmia or severe cardiac impairment. It should also be used with caution in patients with ischemic heart disease or congestive heart failure.Interactions
Metazine MR is known to interact with certain medications, including calcium channel blockers, anticoagulants, antihypertensives, and some antibiotics. It is important to tell your doctor about all medications you are taking prior to starting treatment with trimetazdine.Disease Interactions
Metazine MR should not be used in patients with conditions associated with elevated risk of arrhythmias, including hyperthyroidism, arrhythmia, or prolonged QT syndrome. It can also worsen congestive heart failure, and should not be used in patients with this condition.Drug Interactions
Metazine MR can interact with certain medications, including calcium channel blockers, anticoagulants, antihypertensives, and some antibiotics. It is important to tell your doctor about all medications you are taking prior to starting treatment with trimetazdine.Food Interactions
Metazine MR should be taken with food to reduce the risk of gastrointestinal side effects. Alcohol can also increase the risk of side effects.Pregnancy Use
Metazine MR has not been studied in pregnant women and is not recommended for use during pregnancy.Lactation Use
Metazine MR has not been studied in breastfeeding women and is not recommended for use while breastfeeding.Acute Overdose
Symptoms of an acute overdose can include blurred vision, confusion, dizziness, and increased heartbeat. It is important to seek medical attention immediately if an overdose is suspected.Contraindication
Metazine MR should not be used in patients with conditions associated with elevated risk of arrhythmias, including hyperthyroidism, arrhythmia, or prolonged QT syndrome. It can also worsen congestive heart failure, and should not be used in patients with this condition.Use Direction
Metazine MR should be taken orally with meals, one to three times daily. The dosage should not exceed 60 mg per day.Storage Condition
Metazine MR should be stored in a cool, dry place, away from children.Volume of Distribution
The volume of distribution of trimetazidine is unknown.Half Life
The half-life of trimetazidine is approximately 5-6 hours.Clearance
The clearance of trimetazidine is unknown.Here you find in details version of Metazine MR
Some Frequently Asked Questions About Metazine MR
What is Metazine MR?
Metazine MR is an anti-ischaemic drug used to treat heart-related conditions and symptoms, such as angina and chest pain. It works by decreasing the amount of oxygen that the heart needs under stress, thereby reducing ischaemic symptoms and improving metabolism.
Is Metazine MR addictive?
No, Metazine MR is not known to be addictive.
How does Metazine MR work?
Metazine MR acts as an anti-ischaemic drug, and it works by decreasing the amount of oxygen the heart needs under stress. This reduces ischaemic symptoms and improves metabolism.
How long does Metazine MR take to work?
The effects of Metazine MR may vary from person to person, but it can usually start to show benefits within 4 to 6 weeks.
What are the side effects of Metazine MR?
The most commonly reported side effects of Metazine MR are fatigue, dry mouth, and dizziness. If you experience any other side effects such as an allergic reaction, or swelling in the legs and feet, contact your doctor or pharmacist immediately.
Does Metazine MR interact with other medications?
Yes, Metazine MR can interact with other medications, so it is important to tell your doctor or pharmacist about any other medications you are taking. Also, it is never advisable to take two medications together without consulting your doctor.
Can Metazine MR be used for other purposes?
Metazine MR is not indicated for any conditions other than those related to angina and chest pain. If you think you may be experiencing an unrelated condition, you should consult your doctor for proper diagnosis and treatment.
Can pregnant and breastfeeding women use Metazine MR?
It is not recommended for pregnant and breastfeeding women to take Metazine MR due to a lack of data to support its safe use. Always consult your doctor before taking a medication when pregnant or breastfeeding.
What is the usual dose of Metazine MR?
The standard dose of Metazine MR is 20 mg twice daily. The dosage may be adjusted depending on your response to the medication. Your doctor will be able to advise you on the most suitable dose.
What should I do if I miss a dose of Metazine MR?
If you miss a dose of Metazine MR, take it as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take the next dose as per usual. Never take a double dose to make up for a missed one.
How long should I take Metazine MR for?
Metazine MR should be taken as prescribed for as long as your doctor recommends. Do not stop taking the medication without consulting your doctor.
Can Metazine MR be taken with food?
Yes, Metazine MR can be taken with food. However, it is important to take Metazine MR at the same time every day for optimal benefit.
Can cut Metazine MR tablets in half?
It is not advisable to cut Metazine MR tablets in half as it may interfere with the way the medication works. It is best to take the tablet whole and as prescribed by your doctor or pharmacist.
What should I do if I overdose on Metazine MR?
If you think you have taken too much Metazine MR, contact your doctor or nearest hospital's emergency department immediately. Do not wait until it is too late.
Can I drink alcohol while taking Metazine MR?
It is not recommended to drink alcohol while taking Metazine MR as it may interact with the medication and decrease its effectiveness. If you wish to consume alcohol, it is best to speak to your doctor or pharmacist for advice.
Can Metazine MR cause weight gain?
No, Metazine MR is not known to cause weight gain. If you experience any strange symptoms or side effects whilst taking Metazine MR, it is best to speak to your doctor.
What is the recommended Metazine MR dosage for adult men?
The recommended dosage of Metazine MR for adult men is 20 mg twice daily. This may be adjusted depending on your response to the medication. Ask your doctor for more information.
What is the recommended Metazine MR dosage for adult women?
The recommended dosage of Metazine MR for adult women is 20 mg twice daily. This may be adjusted depending on your response to the medication. Ask your doctor for more information.
Is Metazine MR available as a generic medication?
Yes, Metazine MR is available as a generic medication. Generic medications use the same active ingredients as the branded medication and are just as safe and effective as the branded version.
Is Metazine MR given intravenously?
No, Metazine MR is not usually given intravenously. It is taken orally in tablet or capsule form.
Can children take Metazine MR?
Metazine MR is not recommended in children aged under 18 years. Always check with your doctor before taking any medications in children.
Does Metazine MR reduce blood pressure?
No, Metazine MR does not reduce blood pressure. It is prescribed to treat heart-related conditions such as angina and chest pain.
Will Metazine MR cause me to feel tired?
Yes, fatigue is one of the most commonly reported side effects of Metazine MR. If you are experiencing extreme fatigue, speak to your doctor.
Can Metazine MR cause blurred vision?
No, blurred vision is not a known side effect of Metazine MR. If you are experiencing any changes in your vision whilst taking Metazine MR, speak to your doctor.
Can Metazine MR be used to treat high cholesterol?
No, Metazine MR is not indicated for treating high cholesterol. It is usually prescribed to treat angina and chest pain. If you think you may have an unrelated condition, speak to your doctor.
Does Metazine MR cause muscle aches?
Yes, muscle pain and aches have been reported as a side effect of Metazine MR. If the pain persists or worsens, speak to your doctor.
Are there any side effects associated with long-term use of Metazine MR?
Long-term use of Metazine MR may increase the risk of certain side effects, such as fatigue and dizziness. If you experience any adverse effects with long-term use of Metazine MR, speak to your doctor.
Does Metazine MR thin the blood?
No, Metazine MR does not thin the blood. It is used to treat heart-related conditions such as angina and chest pain.
Can Metazine MR cause abnormal heart rhythms?
Yes, Metazine MR can cause abnormal heart rhythms. If you experience any strange symptoms whilst taking Metazine MR, speak to your doctor.
What is the most common side effect of taking Metazine MR?
The most commonly reported side effect of Metazine MR is fatigue. If you experience any other side effects whilst taking Metazine MR, speak to your doctor.
Can Metazine MR be used to treat angina?
Yes, Metazine MR is indicated for the treatment of angina and chest pain. It works by decreasing the amount of oxygen the heart needs under stress, thereby reducing ischaemic symptoms.
Does Metazine MR have any long-term health benefits?
Yes, Metazine MR has been shown to have long-term health benefits such as improving heart function and reducing the risk of stroke and other cardiovascular events. It is important to take the medication as instructed by your doctor for the best possible outcome.
Does Metazine MR require a prescription?
Yes, Metazine MR requires a prescription from your doctor. Always speak to your doctor before taking any medications.
Are there any lifestyle changes I can make to help with Metazine MR treatment?
Yes, lifestyle changes such as quitting smoking, exercising regularly, and eating a healthy diet can help with Metazine MR treatment and improve overall cardiovascular health. Talk to your doctor for more information.
Does Metazine MR interact with other medications?
Yes, Metazine MR can interact with other medications. It is important to tell your doctor or pharmacist about any other medications you are taking before taking Metazine MR. Also, it is never advisable to take two medications together without consulting your doctor.
Can Metazine MR cause fluid retention?
Yes, fluid retention is one of the side effects associated with Metazine MR. If you experience any swelling in the legs and feet, contact your doctor immediately.
What should I do if I have an allergic reaction to Metazine MR?
If you experience any signs of an allergic reaction such as difficulty breathing, hives, or swelling of the face or throat, seek medical attention immediately. Additionally, stop taking Metazine MR and speak to your doctor about alternative treatments.
What are the possible side effects of Metazine MR?
The most commonly reported side effects of Metazine MR are fatigue, dry mouth, dizziness, and nausea/vomiting. If you experience any other side effects such as an allergic reaction, or swelling in the legs and feet, contact your doctor or pharmacist immediately.
Can Metazine MR be used to treat high blood pressure?
No, Metazine MR is not indicated for treating high blood pressure. It is usually prescribed to treat angina and chest pain. If you think you may have an unrelated condition, speak to your doctor.
Can Metazine MR be used to treat diabetes?
No, Metazine MR is not indicated for treating diabetes. It is usually prescribed to treat angina and chest pain. If you think you may have an unrelated condition, speak to your doctor.
What should I do if I experience any side effects whilst taking Metazine MR?
If you experience any side effects whilst taking Metazine MR, speak to your doctor or pharmacist. Your doctor may be able to adjust the dosage or recommend alternative treatments.
What is the cost of Metazine MR?
The cost of Metazine MR will vary depending on your location and the pharmacy you use. It is best to speak to your local pharmacist for up-to-date prices.