Mespa

Mespa Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Mespa is a brand name. Its generic name is Mebeverine.

Mespa Introduction

Mespa is an antispasmodic drug which is used to relax the muscles in the digestive system. Mespa hydrochloride is the hydrochloride salt of an ethylenediamine derivative, mebeverine. It is used in the symptomatic treatment of gastrointestinal spasm associated with irritable bowel syndrome. It helps to reduce symptoms such as stomach cramps, abdominal pain, and irregular and painful bowel movements.

Uses For

Mespa is used to treat cramps or spasms of the stomach and intestines. It is also used to treat irritable bowel syndrome.

Mechanism of Action

Mespa works to relax the muscles at the level of the stomach and intestine walls to help reduce abdominal pain, cramps, and irritable bowel syndrome (IBS). It acts on muscarinic receptors (cholinergic receptors) within the intestines, slowing the rate of muscle contraction. This slows the passage of food through the digestive system, increasing the absorption of water through the bowels and ultimately alleviating cramps, pain, and other IBS symptoms.

How Long Does It Take To Work?

Mespa usually starts to work within 1-2 hours of taking the tablet, although in some cases it may take up to 3 days to feel the full effect.

Absorption

Mespa is rapidly and almost completely absorbed after oral administration. Peak plasma concentrations are achieved 1 to 2 hours after administration. Mespa has a bioavailability of approximately 90%; it is not significantly influenced by food.

Route of Elimination

Mespa is eliminated by hepatic metabolism to inactive metabolites. The metabolites are excreted mainly in the urine.

Dosage

Mespa is available as tablets or as capsules that can be taken orally. Usual adult dosage is 135 mg three times per day between meals, and the usual dosage for children is 20-45 mg three times per day between meals.

Administration

Mespa should be taken with a glass of water before meals, with meals or after meals. It can be taken with or without food. It is important to take mebeverine on a regular basis and at the same time each day as this will help the patient to remember to take it and increase the chances of receiving the maximum benefit.

Side Effect

Common side effects of mebeverine include headache, nausea, abdominal pain, and dizziness. Rare side effects include severe allergic reactions (anaphylactic reaction), Stevens-Johnson syndrome, increased tear production, blurred vision, chest pain, and difficulty breathing.

Toxicity

Mespa is generally well tolerated and has a low toxicity profile. In animal studies, the LD50 is shown to be greater than 12g/kg body weight.

Precaution

Patients should inform their doctor of any other medications they take, as well as any history of asthma, eczema or an allergy, or any other allergies (e.g. food allergies). Mespa should be used cautiously in patients with a history of seizures, kidney or liver disease, or a certain type of intestinal obstruction.

Interaction

Mespa may interact with certain medications like antacids, digoxin, warfarin, and metoclopramide. Patients should inform their doctor of all medications taken prior to taking mebeverine as these could interact and increase the risk of side effects occurring.

Disease Interaction

Mespa is not suitable for use by patients with a tachycardia, hypersensitivity to mebeverine, or bladder/intestinal obstruction.

Drug Interaction

Mespa may interact with certain medications such as antacids, digoxin, warfarin, and metoclopramide, increasing the risk of side effects.

Food Interactions

Mespa is not known to interact with food. However, it may interact with foods high in tyramine such as aged cheese, yogurt, smoked fish, and certain beers or wines.

Pregnancy Use

Mespa is not recommended for use during pregnancy. It is not known if mebeverine can pass into breast milk, but it is unlikely to cause harm to a nursing infant.

Lactation Use

Mespa is not recommended for use while breastfeeding as it is not known if mebeverine can pass into breast milk and cause harm to an infant.

Acute Overdose

In case of an acute overdose of mebeverine, doctors may recommend gastric lavage, activated charcoal and supportive measures in order to absorb and eliminate the drug.

Contraindication

Mespa is contraindicated in patients with a known sensitivity or allergy to mebeverine, other lincomycin antibiotics, or any of the other ingredients in the product.

Use Direction

Mespa tablets should be taken orally, with a glass of water before, with, or after meals. Do not take more than the prescribed dose or exceed the recommended frequency.

Storage Condition

Mespa should be stored at room temperature in a dry, dark place away from heat and direct sunlight. Keep it in a tightly sealed container, away from children and pets.

Volume of Distribution

The volume of distribution of mebeverine is 4.8 L/kg.

Half Life

The elimination half-life of mebeverine is 7 hours.

Clearance

The clearance of mebeverine is 116 ml/min/1.73 m2.

Here you find in details version of Mespa

Some Frequently Asked Questions About Mespa

What is Mespa?

Mespa is a medication used to treat irritable bowel syndrome (IBS), and inflammatory bowel disease (such as ulcerative colitis and Crohn's disease). It works by slowing down the movement of the muscles in the intestine, which helps reduce pain and cramping.

How does Mespa work?

Mespa works by decreasing the contractile activity of the muscles in the intestine which helps reduce pain and cramping that is associated with irritable bowel syndrome (IBS) and certain inflammatory bowel diseases (ulcerative colitis and Crohn's disease).

What are the side effects of Mespa?

The most common side effects associated with taking mebeverine include nausea, vomiting, constipation, and headache. Other possible side effects include dry mouth, insomnia, nervousness, dizziness, diarrhoea, and skin rash.

Do I need a prescription for Mespa?

Yes, Mespa is a prescription medication and must be obtained from your doctor or healthcare provider.

How should Mespa be taken?

Mespa should be taken exactly as prescribed by your doctor or healthcare provider. Do not change your dose or stop taking Mespa without first consulting with your healthcare provider.

Is Mespa safe?

Yes, Mespa is generally considered safe when taken as prescribed by a medical professional. However, there may be certain side effects associated with taking Mespa. Check with your doctor or healthcare provider for more information.

Can I take Mespa with other medications?

It is important to tell your doctor or healthcare provider if you are taking any other medications, including over-the-counter medications, herbal remedies or supplements. Do not take any new medication without first consulting your doctor or healthcare provider.

How long does it take for Mespa to work?

The effects of Mespa can be felt within several days of beginning treatment. However, it may take a few weeks before the full benefits of Mespa are experienced.

Is Mespa a narcotic?

No, Mespa is not a narcotic and does not have any mind-altering or psychoactive properties.

Can Mespa be used for other purposes?

Mespa is only approved for the treatment of irritable bowel syndrome (IBS) and certain inflammatory bowel diseases (ulcerative colitis and Crohn's disease). Do not take Mespa for any other purpose than what is prescribed by your doctor or healthcare provider.

Can Mespa be taken with food?

It is recommended to take Mespa with food or shortly after eating. Taking Mespa with food will help reduce the risk of stomach upset and other side effects.

Can I drink alcohol while taking Mespa?

It is not recommended to consume alcohol while taking Mespa. Consuming alcohol may increase the risk of side effects or decrease the effectiveness of the medication.

Is Mespa habit forming?

No, Mespa is not habit-forming and does not produce any type of physical or psychological dependence.

What should I do if I miss a dose?

If you miss a dose of Mespa, take it as soon as possible. If it is close to your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double your dose to make up for the missed dose.

What should I do if I overdose on Mespa?

If you think you have overdosed on Mespa, seek immediate medical attention. Overdosing on Mespa can cause serious side effects and should be treated as soon as possible.

What are the possible interactions with Mespa?

It is important to tell your doctor or healthcare provider about any medications, supplements, or herbal remedies you are taking before starting treatment with Mespa. Certain medications, supplements, or herbal remedies may interact with the medication and increase the risk of side effects.

Can Mespa be used during pregnancy?

There is limited data available on the use of Mespa during pregnancy and it should be used only when clearly needed. Pregnant women should consult with their doctor or healthcare provider to determine the risks and benefits of taking Mespa during pregnancy.

Can Mespa be used while breast-feeding?

There is no data available on the use of Mespa while breast-feeding and it should be used only when clearly needed. Women who are breast-feeding should consult with their doctor or healthcare provider to determine the risks and benefits of taking Mespa while breast-feeding.

Should I take Mespa every day?

Mespa should be taken as prescribed by your doctor or healthcare provider. Generally it is taken 3 times per day, preferably with meals. Do not take more or less than the recommended dose, and do not stop taking the medication without consulting your doctor or healthcare provider.

Can I stop taking Mespa without consulting my doctor?

No, it is not recommended to stop taking Mespa without first consulting with your doctor or healthcare provider. Abruptly stopping Mespa may worsen your symptoms and lead to other complications.

When will I notice improvement in my symptoms?

The effects of Mespa may be felt within several days of beginning treatment. However, it may take a few weeks before the full benefits of Mespa are experienced.

Is Mespa safe for long-term use?

Mespa is generally considered safe for long-term use, when taken as prescribed by a medical professional. However, it is important to tell your doctor if you experience any side effects or if your symptoms worsen while taking Mespa.

Can Mespa be used in children?

Mespa is not recommended for use in children under 12 years of age. Children who are 12 years and older should take Mespa only as directed by their doctor or healthcare provider.

Can I take Mespa with other medications?

It is important to tell your doctor or healthcare provider if you are taking any other medications, including over-the-counter medications, herbal remedies or supplements. Do not take any new medication without first consulting your doctor or healthcare provider.

Are there any allergies associated with Mespa?

It is not known if people who are allergic to Mespa will have an allergic reaction to other medications. Check with your doctor or healthcare provider about any allergies you may have, or if you are taking any medications for any allergies.

What flavours of Mespa are available?

Mespa is available in tablets, capsules, and syrup form. The tablets and capsules are available in various flavours, including berry, lemon, orange and vanilla.

Are there any other conditions that I should tell my doctor about before taking Mespa?

Yes, it is important to tell your doctor about any other medical conditions you may have, as these may affect the way Mespa works. Make sure to tell your doctor about allergies, any other medications you are taking, or any other medical conditions you may have.

Should I take Mespa if I have a history of liver disease?

It is not recommended to take Mespa if you have a history of liver disease, as it may cause serious side effects. Your doctor may be able to prescribe an alternative medication that is more suitable for you.

What should I do if I experience any unusual symptoms while taking Mespa?

If you experience any unusual symptoms while taking Mespa, such as dizziness, nausea, fatigue and difficulty breathing, contact your doctor or healthcare provider immediately. Do not stop taking Mespa without first consulting with your doctor or healthcare provider.

Can I take Mespa with antacids?

It is not recommended to take Mespa with antacids, as antacids may decrease the effectiveness of the medication. Talk to your doctor or healthcare provider about suitable alternatives.

Can I take Mespa with other IBS medications?

It is important to tell your doctor or healthcare provider about all medications you are taking, including any IBS medications, before starting treatment with Mespa. Certain medications may interact with Mespa and increase the risk of side effects.

What should I do if I experience any stomach pain while taking Mespa?

If you experience any stomach pain while taking Mespa, it is important to contact your doctor or healthcare provider immediately. Do not stop taking Mespa without first consulting with your doctor or healthcare provider.

Can I take Mespa with antidepressants?

It is important to tell your doctor or healthcare provider about all medications you are taking before starting treatment with Mespa. Certain medications, including antidepressants, may interact with Mespa and increase the risk of side effects.

Can Mespa be used to treat other conditions than irritable bowel syndrome (IBS) and inflammatory bowel diseases (ulcerative colitis and Crohn's disease)?

No, Mespa is only approved for the treatment of irritable bowel syndrome (IBS) and certain inflammatory bowel diseases (ulcerative colitis and Crohn's disease). Do not take Mespa for any other purpose than what is prescribed by your doctor or healthcare provider.

Is Mespa available over-the-counter?

No, Mespa is a prescription medication and must be obtained from your doctor or healthcare provider.

Can I take Mespa if I have a history of kidney disease?

Mespa is not recommended for people with a history of kidney disease, as it may cause serious side effects. Your doctor may be able to prescribe an alternative medication that is more suitable for you.

Are there any age restrictions for taking Mespa?

Mespa is not recommended for children under 12 years of age. Children who are 12 years and older should take Mespa only as directed by their doctor or healthcare provider.

How should I store Mespa?

Mespa should be stored at room temperature, away from direct sunlight, moisture, and heat. Keep out of the reach of children and pets.