Mesacol

Mesacol Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Mesacol is a brand name. Its generic name is Mesalazine.

Mesacol Introduction

Mesacol (also known as 5-aminosalicylic acid, 5-ASA) is a drug used to treat conditions such as ulcerative colitis, Crohn's disease, and pouchitis. It is an anti-inflammatory medication used to reduce inflammation in the digestive tract. It is also known to help with the management of pain, and to reduce the risk of developing colorectal cancer. It is available in oral, suppository, and topical forms.

Mechanism of Action

Mesacol works by blocking the effects of certain hormones and enzymes that cause inflammation in the digestive system. By blocking these hormones and enzymes, mesalazine helps to reduce inflammation and relieve symptoms of ulcerative colitis and other digestive diseases.

How Long Does it Take to Work?

Mesacol works differently for different people, but it usually takes between three to six weeks before any noticeable improvement is seen. It is important to take mesalazine as directed by your doctor and not to stop taking the medication once you feel better.

Absorption

Mesacol is well absorbed from the gastrointestinal tract, with peak plasma levels occurring approximately three hours after administration. The absorption of mesalazine is pH-dependent, with the maximum absorption occurring in the presence of a high pH.

Route of Elimination

Mesacol is eliminated primarily by the kidneys in the form of metabolites. Approximately 30% of the drug is eliminated unchanged in the urine.

Dosage

The dosage of mesalazine varies depending on the type of condition that is being treated. The usual recommended dose is 2 to 4 g daily in divided doses. Older adults may require lower doses due to reduced kidney and liver function. In general, there is no need to increase the dose above 4 g per day unless there is evidence of inadequate response.

Administration

Mesacol can be taken orally as tablets or capsules, via suppository, or as a topical formulation. If taking it orally, it should be taken with meal or snack to improve the absorption of the drug. When taken as a topical formulation, it should be applied directly to the affected area.

Side Effects

Common side effects of mesalazine include nausea, diarrhea, abdominal pain, headache, dizziness, and rash. Severe side effects may include allergic reactions, bleeding from the rectum, and liver or kidney damage. Patients should notify their doctor immediately if they experience any of these side effects.

Toxicity

Mesacol is generally considered safe and well-tolerated when taken at the recommended dosage. However, it may cause serious side effects at higher doses, including liver and kidney damage.

Precautions

Patients taking mesalazine should avoid consuming alcohol during treatment and inform their doctor of any other medications they are taking, including non-prescription drugs and herbal remedies. Additionally, patients should inform their doctor if they have any existing or past liver or kidney problems, or if they are pregnant or breastfeeding.

Interactions

Mesacol may interact with other medications, including some antibiotic drugs. Patients should inform their doctor of all other medications they are taking in order to avoid any potential interactions.

Disease Interactions

Mesacol may interact with certain diseases, including poor kidney or liver function and active infections. It is important for patients to inform their doctor of any existing health conditions in order to avoid potential interactions.

Drug Interactions

Mesacol may interact with certain drugs, such as certain antibiotics. It is important to tell your doctor about all other drugs you are taking to avoid any potential interactions.

Food Interactions

Mesacol does not interact with food, but it is important to take it with meals or snacks in order to improve its absorption.

Pregnancy Use

Mesacol is not recommended during pregnancy. Women who become pregnant while using the medication should contact their doctor immediately.

Lactation Use

Mesacol is not recommended for use during breastfeeding due to the risk of passing the drug to the baby through breast milk. Women who become pregnant while using the medication should contact their doctor immediately.

Acute Overdose

Patients who overdose on mesalazine may experience dizziness, nausea, vomiting, and abdominal pain. These symptoms should be treated with supportive care.

Contraindications

Mesacol is contraindicated in patients with a known hypersensitivity to the drug or with severe renal or hepatic impairment.

Use Direction

Mesacol should be taken as directed by your doctor. It is available as tablets or capsules, suppositories, and topical formulations. When taken orally, it should be taken with food or a snack to improve its absorption.

Storage Conditions

Mesacol should be stored at room temperature, out of direct light and moisture. It should be kept away from children and pets.

Volume of Distribution

Mesacol has a volume of distribution of approximately 20-60 L/kg.

Half Life

The half-life of mesalazine is approximately 1.6 hours.

Clearance

Mesacol is eliminated primarily by the kidneys, with approximately 30% of the drug being eliminated unchanged in the urine. The clearance of the drug is approximately 10-15 ml/min/kg.

Here you find in details version of Mesacol

Some Frequently Asked Questions About Mesacol

What is mesalazine?

Mesacol (also known as mesalamine) is an anti-inflammatory drug used to treat and prevent ulcerative colitis. It works by suppressing the inflammation that causes ulcerative colitis symptoms.

How does mesalazine work?

Mesacol works by inhibiting the production of pro-inflammatory compounds called prostaglandins. In addition, it prevents the release of cytokines, which are molecules that promote inflammation. These anti-inflammatory effects help to reduce and prevent the symptoms of ulcerative colitis such as pain, diarrhea and bleeding.

What is mesalazine used for?

Mesacol is used to treat and prevent ulcerative colitis. It can also be used to treat mild to moderate Crohn's disease.

What are the possible side effects of mesalazine?

The most common side effects of mesalazine are nausea, headache, and upset stomach. Other possible side effects may include joint pain, dizziness, and rash.

What if I miss a dose of mesalazine?

If you miss a dose, take it as soon as you remember and then resume your regular schedule. Do not take two doses at the same time.

What should I avoid while taking mesalazine?

You should avoid alcohol and tobacco while taking mesalazine, as they can increase your risk of side effects. You should also avoid activities that may increase your risk of bleeding such as contact sports.

Is mesalazine safe for long-term use?

Yes, mesalazine is safe for long-term use when used at the recommended doses and under the supervision of your doctor. However, long-term use of mesalazine may increase your risk of certain side effects such as headaches, nausea, and anemia.

What is the recommended dosage of mesalazine?

The recommended dosage of mesalazine generally ranges from 1-2g daily, although dosage may vary depending on the condition being treated. Your doctor will determine what is right for you.

What are the different forms of mesalazine?

Mesacol is available in several forms, including tablets, capsules, suppositories and enemas. Your doctor will determine which form is right for you.

Are there any drug interactions with mesalazine?

Yes, mesalazine can interact with other medications, including aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, and immunosuppressants. You should tell your doctor about all medications you take before starting mesalazine.

What if I have liver or kidney disease?

If you have liver or kidney disease, your doctor may monitor your condition more closely while taking mesalazine or may adjust your dosage accordingly. Mesacol should be used with caution in those with liver or kidney disease.

What if I am pregnant or breast-feeding?

Mesacol should be used with caution during pregnancy or when breastfeeding. It is not recommended for those who are pregnant or breastfeeding. Talk to your doctor if you are pregnant or breastfeeding and need to take mesalazine.

What if I am taking other medications?

Before taking mesalazine, tell your doctor about all medications you are taking, including over-the-counter medications such as aspirin, vitamins, supplements, and herbal products. Your doctor will monitor your condition and adjust your medications accordingly.

What should I tell my doctor before taking mesalazine?

Before taking mesalazine, tell your doctor about any medical conditions you have, including liver or kidney disease, and any medications you are currently taking. Also tell your doctor if you are pregnant or breastfeeding.

Can mesalazine be taken with food?

Yes, mesalazine can be taken with food. Taking it with food may help reduce stomach upset.

What if I experience a serious side effect?

If you experience a serious side effect such as rash, severe abdominal pain, increased blood pressure, confusion, or difficulty breathing, stop taking mesalazine and contact your doctor or emergency services immediately.

Is mesalazine available over-the-counter?

No, mesalazine is a prescription medication and is not available over-the-counter.

Is mesalazine covered by insurance?

Yes, mesalazine is generally covered by insurance. However, coverage and cost will vary depending on your insurance company and your deductible.

What is the cost of mesalazine?

The cost of mesalazine will vary depending on your insurance coverage, form of the medication, and dosage. The average cash price for 30 tablets ranges from $10-$50.

Is mesalazine safe for children?

Mesacol is generally not recommended for children under the age of 12, as safety and efficacy have not been established in this population.

Can mesalazine be used to treat Crohn's disease?

Yes, mesalazine is sometimes used to treat mild to moderate Crohn's disease. It is most commonly used to maintain remission in people with moderate to severe Crohn's disease.

Are there any natural alternatives to mesalazine?

Yes, there are several natural alternatives to mesalazine, such as probiotics, quercetin, and curcumin. However, it is important to discuss these options with your doctor before taking them as they may interact with other medications.

What are the benefits of taking mesalazine?

The benefits of taking mesalazine include reducing the symptoms of ulcerative colitis such as pain, diarrhea, and bleeding. It can also help maintain remission in those with Crohn's disease.

Can mesalazine be used to treat other conditions?

Mesacol can be used to treat other inflammatory conditions such as psoriasis and diverticulitis, although it is not approved for this use.

Is mesalazine safe for people with allergies?

Mesacol is generally considered safe for people with allergies. However, you should inform your doctor about any allergies before starting treatment with mesalazine. Also inform them about any other medications or supplements you are taking.

How long should I take mesalazine for?

It depends on your condition and the severity of your symptoms. In general, mesalazine should be taken for a minimum of 6-8 weeks. Your doctor may recommend a longer course of treatment depending on your condition.

Are there any foods I should avoid while taking mesalazine?

Yes, you should avoid foods high in fiber and sugar such as fruits, vegetables, nuts, seeds, and high-fiber grains. You should also avoid processed and fried food, and alcoholic beverages.

What if I experience a flare-up while taking mesalazine?

If you experience a flare-up, contact your doctor right away. Your doctor may adjust your medications or recommend other treatments to help manage your symptoms.

Is mesalazine addictive?

No, mesalazine is not addictive.

What is the best time of day to take mesalazine?

It is best to take mesalazine at the same time each day. If you miss a dose, take it as soon as you remember. Do not take two doses at the same time.

Are there any over-the-counter products that can be used with mesalazine?

Yes, there are several over-the-counter products such as antacids and probiotics that may be used in conjunction with mesalazine. Talk to your doctor before taking any additional products.

Are there any other medications I can take instead of mesalazine?

Yes, there are several other medications you can take to treat ulcerative colitis, including mercaptopurine, sulfasalazine, and budesonide. Talk to your doctor to decide which one is right for you.

Does mesalazine cause weight gain?

No, mesalazine is not known to cause weight gain. However, it can cause other side effects such as nausea and upset stomach which may lead to reduced appetite and weight loss.

What is the difference between mesalazine and sulfasalazine?

Mesacol and sulfasalazine are both anti-inflammatory medications used to treat ulcerative colitis. The main difference between the two is that mesalazine is more concentrated and is thus more potent than sulfasalazine.

What is mesalazine's half-life?

The half-life of mesalazine is between 4-6 hours.

Is mesalazine a steroid?

No, mesalazine is not a steroid. It is an anti-inflammatory medication.

What should I do if I experience an allergic reaction to mesalazine?

If you experience a rash, difficulty breathing, or swelling of the face, lips or tongue, stop taking mesalazine and seek immediate medical attention. You may be having an allergic reaction to the medication.

Can mesalazine be used to treat irritable bowel syndrome (IBS)?

No, mesalazine is not recommended for the treatment of irritable bowel syndrome (IBS). Your doctor may recommend other treatments for IBS.