Medroxyacetate Progesterone

Medroxyacetate Progesterone, a brand name for a formulation containing essential Medroxyprogesterone Acetate, is widely used for various health benefits. This guide provides comprehensive information on the uses, dosage, side effects, and mechanism of action of Medroxyacetate Progesterone, as well as insights into how long it takes to work. Understanding these aspects can help you make informed decisions about its use and effectiveness.


Medroxyacetate Progesterone is a hormonal therapy that is used to treat various female reproductive conditions, such as irregular menstrual cycles and endometriosis. It is a synthetic form of the progesterone hormone and comes in the form of an injectable or pill. It is typically used to suppress ovulation or to treat symptoms of certain reproductive and hormonal conditions.


Medroxyacetate Progesterone is used to treat a wide variety of female reproductive conditions, including:
  • Endometriosis
  • Premenstrual Syndrome (PMS)
  • Unexplained irregular menstrual cycles
  • Thin endometrial lining of the uterus
  • Premature ovarian failure
  • Abnormal uterine bleeding
  • Uterine fibroids
  • Adenomyosis
  • Hirsutism

Mechanism of Action

Medroxyacetate Progesterone works by binding to the progesterone receptors in the body, thus mimicking the function of the natural progesterone hormone. Progesterone has several effects throughout the body, including promoting healthy menstrual cycles, modulating endometrial growth, and suppressing the release of certain hormones. When Medroxyacetate Progesterone binds to the progesterone receptors, it mimics the effects of the natural hormone, thus regulating the menstrual cycle and treating any underlying female reproductive symptoms.

How Long Does it Take to Work?

The effects of Medroxyacetate Progesterone can be felt within a few days or weeks after the first dose. It usually takes a few months for the maximum effects to be felt. However, this varies depending on the individual and the severity of the condition being treated.


When taken orally, Medroxyacetate Progesterone is absorbed into the bloodstream through the gastrointestinal tract. When taken intramuscularly, it is absorbed directly into the bloodstream.

Route of Elimination

Medroxyacetate Progesterone is eliminated from the body mainly through the kidneys and intestine.


The dosage of Medroxyacetate Progesterone varies according to the medical condition being treated, but generally ranges from 2.5 mg to 30 mg daily. The dosage is typically one to three injected doses per month. For oral pills, the dosage can range from 5 mg to 40 mg daily.


Medroxyacetate Progesterone can be administered orally as a pill or intramuscularly as an injection.

Side Effect

Common side effects of Medroxyacetate Progesterone include nausea, headache, and breast tenderness. Other side effects include weight gain, acne, stomach cramping, mood swings, and depression.


Medroxyacetate Progesterone is generally considered safe and has a low level of toxicity.


Before taking Medroxyacetate Progesterone, it is important to tell your doctor if you have any medical conditions, allergies, or if you are taking any other medications.


Medroxyacetate Progesterone may interact with certain medications, such as blood thinners, antiepileptic drugs, and other hormones.

Disease Interactions

Medroxyacetate Progesterone may interact with certain medical conditions, such as liver or kidney disease, asthma, seizures, and high blood pressure.

Drug Interactions

Medroxyacetate Progesterone may interact with certain drugs, such as antiepileptic drugs and blood thinners.

Food Interactions

Medroxyacetate Progesterone may interact with certain foods, such as grapefruit and grapefruit juice.

Pregnancy Use

Medroxyacetate Progesterone should not be used during pregnancy as it can cause harm to the developing fetus.

Lactation Use

Medroxyacetate Progesterone should not be used during lactation as it can pass into the breast milk and cause harm to the nursing infant.

Acute Overdose

Overdose of Medroxyacetate Progesterone may cause symptoms such as nausea, vomiting, confusion, increased heart rate, problems breathing, drowsiness, and seizures. If an overdose is suspected, seek medical attention immediately.


Medroxyacetate Progesterone should not be used for women who are pregnant or are breastfeeding. It should also not be used for women with a history of heart disease, stroke, or blood clotting disorders.

Use Directions

Medroxyacetate Progesterone should only be used according to the directions provided by your healthcare provider. It should never be taken for longer than recommended, and any unused medication should be disposed of safely.

Storage Conditions

Medroxyacetate Progesterone should be stored at room temperature, away from moisture and heat. It should also be kept out of the reach of children.

Volume of Distribution

The volume of distribution of Medroxyacetate Progesterone is very low.

Half Life

The half-life of Medroxyacetate Progesterone is approximately 16 hours.


The clearance of Medroxyacetate Progesterone is approximately 1.8 L/h.

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