Malomin

Malomin Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Malomin is a brand name. Its generic name is Pyrimethamine.

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Malomin Introduction

Malomin, also known as Daraprim, is an antimalarial and antiparasitic medication used to treat protozoal infections such as malaria and toxoplasmosis. It is also sometimes used to treat other diseases such as rosacea. Malomin is available in tablet form and is available by prescription from a doctor.

Uses for Malomin

Malomin is used to treat a variety of protozoal infections, including malaria and toxoplasmosis. In addition, it is also sometimes used to treat other diseases such as rosacea.

Mechanism of Action

Malomin works by inhibiting the growth of protozoal parasites by decreasing the production of nucleic acid, a building block of DNA and RNA. This causes the parasites to die. In addition, it may also inhibit the ability of certain types of bacteria to replicate.

How Long Does It Take to Work?

The exact amount of time it takes for pyrimethamine to start working depends on the type and severity of the infection being treated. Generally speaking, it may take several days for the drug to start working and full effect may not be seen for up to a few weeks.

Absorption

Malomin is rapidly and completely absorbed from the gastrointestinal tract.

Route of Elimination

Malomin is largely metabolized in the liver and then eliminated in the urine and feces.

Dosage

The dosage of pyrimethamine to be given depends upon the type and severity of the infection being treated and the age and weight of the patient. Generally, an adult should start with a dosage of 25-50 mg once a day. The dosage can then be increased as necessary up to a maximum of 400 mg per day. Children should not exceed 25 mg per day regardless of their age and weight.

Administration

Malomin should be taken orally with a full glass of water. It is best to take it with food or a snack to decrease the chance of nausea and stomach upset.

Side Effect

Malomin may cause side effects including nausea, vomiting, diarrhea, dizziness, headache, and rash. If these side effects become severe or persistent, they should be reported to a doctor.

Toxicity

Malomin can be toxic if taken in high doses or for prolonged periods. Symptoms of an overdose may include confusion, difficulty breathing, coma, and death.

Precaution

Patients should not take pyrimethamine if they are allergic to the drug, have kidney or liver problems, or are pregnant or breastfeeding. Additionally, patients should inform their doctor of any drugs they are currently taking, as pyrimethamine may interact with them.

Interaction

Malomin may interact with other drugs, including antibiotics, antifungals, antivirals, and anticonvulsants. Patients should inform their doctor of any drugs they are currently taking, as pyrimethamine may interact with them.

Disease Interaction

Malomin may interact with certain diseases, such as kidney disease, liver disease, immune system disorders, and diabetes. Patients should inform their doctor of any underlying conditions before taking pyrimethamine.

Drug Interaction

Food Interactions

Malomin may interact with certain foods. Foods that may interact with pyrimethamine include dairy products, calcium-rich foods, foods containing magnesium or iron, and caffeine-containing foods and drinks. It is important to let your doctor know if you are taking any of these foods.

Pregnancy Use

Malomin is classified as a pregnancy category C drug. This means that it may be safe to take during pregnancy, but the potential risks are not yet known. Women who are pregnant or planning to become pregnant should speak to their doctor before taking this medication.

Lactation Use

Malomin should not be used by women who are breastfeeding, as it could pass into breast milk and affect the baby. Women should talk to their doctor before taking this medication if they are breastfeeding.

Acute Overdose

An acute overdose of pyrimethamine is an emergency and can be fatal. Symptoms of an overdose may include confusion, difficulty breathing, coma, and death. Patients who suspect an overdose should seek medical attention immediately.

Contraindication

Use Directions

Malomin should be taken orally with a full glass of water. It is best to take it with food or a snack to decrease the chance of nausea and stomach upset. The dosage of pyrimethamine to be given depends upon the type and severity of the infection being treated and the age and weight of the patient. Generally, an adult should start with a dosage of 25-50 mg once a day. The dosage can then be increased as necessary up to a maximum of 400 mg per day. Children should not exceed 25 mg per day regardless of their age and weight.

Storage Condition

Malomin should be stored in a tightly closed container at room temperature and out of reach of children. Do not store it in areas of high heat or humidity, such as a bathroom or kitchen.

Volume of Distribution

The volume of distribution for pyrimethamine is approximately 16 liters.

Half Life

The elimination half-life of pyrimethamine is approximately 4-6 hours at usual doses.

Clearance

The renal clearance of pyrimethamine is approximately 12-18 mL/min.

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